A miniaturized clark oxygen sensor for organ-on-chip devices

Elsbeth G.B.M. Bossink, Olivier Y.F. Henry, Maximilian A. Benz, Loes Segerink, Donald E. Ingber, Mathieu Odijk

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Abstract

Oxygen concentration is an essential regulatory parameter in cell culture and organ-on-chip devices. Measuring variations in oxygen concentration near cells during cell culture can provide a wealth of information on cell viability, cellular activity, cell differentiation and response to external stimuli. Here, we present a miniaturized three-electrode Clark oxygen sensor, which is shown to be biocompatible, protected from biofouling and has a 7.5s response time. This miniaturized sensor allows to measure the oxygen concentration in a microfluidic channel of an organ-on-chip, whereby this chemical microenvironment can be monitored.
Original languageEnglish
Title of host publicationMicroTAS 2018
Subtitle of host publication22nd International Conference on Miniaturized Systems for Chemistry and Life Science
EditorsFan-Gang Tseng, Gwo-Bin Lee
PublisherThe Chemical and Biological Microsystems Society
Pages889-892
Number of pages4
ISBN (Electronic)978-1-510-89757-1
ISBN (Print)978-0-578-40530-8
Publication statusPublished - 11 Nov 2018
Event22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2018 - Kaohsiung Exhibition Center, Kaohsiung, Taiwan, Province of China
Duration: 10 Nov 201815 Nov 2018
Conference number: 22
https://cbmsociety.org/conferences/microtas2018/

Conference

Conference22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2018
Abbreviated titleMicroTAS 2018
CountryTaiwan, Province of China
CityKaohsiung
Period10/11/1815/11/18
Internet address

Keywords

  • Clark oxygen sensor
  • Miniaturization
  • Oxygen concentration
  • Organ-on-a-chip

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  • Cite this

    Bossink, E. G. B. M., Henry, O. Y. F., Benz, M. A., Segerink, L., Ingber, D. E., & Odijk, M. (2018). A miniaturized clark oxygen sensor for organ-on-chip devices. In F-G. Tseng, & G-B. Lee (Eds.), MicroTAS 2018: 22nd International Conference on Miniaturized Systems for Chemistry and Life Science (pp. 889-892). The Chemical and Biological Microsystems Society.