A miniaturized clark oxygen sensor for organ-on-chip devices

Elsbeth G.B.M. Bossink, Olivier Y.F. Henry, Maximilian A. Benz, Loes Segerink, Donald E. Ingber, Mathieu Odijk

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    Abstract

    Oxygen concentration is an essential regulatory parameter in cell culture and organ-on-chip devices. Measuring variations in oxygen concentration near cells during cell culture can provide a wealth of information on cell viability, cellular activity, cell differentiation and response to external stimuli. Here, we present a miniaturized three-electrode Clark oxygen sensor, which is shown to be biocompatible, protected from biofouling and has a 7.5s response time. This miniaturized sensor allows to measure the oxygen concentration in a microfluidic channel of an organ-on-chip, whereby this chemical microenvironment can be monitored.
    Original languageEnglish
    Title of host publicationMicroTAS 2018
    Subtitle of host publication22nd International Conference on Miniaturized Systems for Chemistry and Life Science
    Pages889-892
    Number of pages4
    Publication statusPublished - 11 Nov 2018
    Event22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2018 - Kaohsiung Exhibition Center, Kaohsiung, Taiwan, Province of China
    Duration: 10 Nov 201815 Nov 2018
    Conference number: 22
    https://cbmsociety.org/conferences/microtas2018/

    Conference

    Conference22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2018
    Abbreviated titleMicroTAS 2018
    CountryTaiwan, Province of China
    CityKaohsiung
    Period10/11/1815/11/18
    Internet address

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    Oxygen
    Equipment and Supplies
    Cell Culture Techniques
    Biofouling
    Microfluidics
    Microelectrodes
    Reaction Time
    Cell Differentiation
    Cell Survival

    Keywords

    • Clark oxygen sensor
    • Miniaturization
    • Oxygen concentration
    • Organ-on-a-chip

    Cite this

    Bossink, E. G. B. M., Henry, O. Y. F., Benz, M. A., Segerink, L., Ingber, D. E., & Odijk, M. (2018). A miniaturized clark oxygen sensor for organ-on-chip devices. In MicroTAS 2018: 22nd International Conference on Miniaturized Systems for Chemistry and Life Science (pp. 889-892)
    Bossink, Elsbeth G.B.M. ; Henry, Olivier Y.F. ; Benz, Maximilian A. ; Segerink, Loes ; Ingber, Donald E. ; Odijk, Mathieu . / A miniaturized clark oxygen sensor for organ-on-chip devices. MicroTAS 2018: 22nd International Conference on Miniaturized Systems for Chemistry and Life Science. 2018. pp. 889-892
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    title = "A miniaturized clark oxygen sensor for organ-on-chip devices",
    abstract = "Oxygen concentration is an essential regulatory parameter in cell culture and organ-on-chip devices. Measuring variations in oxygen concentration near cells during cell culture can provide a wealth of information on cell viability, cellular activity, cell differentiation and response to external stimuli. Here, we present a miniaturized three-electrode Clark oxygen sensor, which is shown to be biocompatible, protected from biofouling and has a 7.5s response time. This miniaturized sensor allows to measure the oxygen concentration in a microfluidic channel of an organ-on-chip, whereby this chemical microenvironment can be monitored.",
    keywords = "Clark oxygen sensor, Miniaturization, Oxygen concentration, Organ-on-a-chip",
    author = "Bossink, {Elsbeth G.B.M.} and Henry, {Olivier Y.F.} and Benz, {Maximilian A.} and Loes Segerink and Ingber, {Donald E.} and Mathieu Odijk",
    year = "2018",
    month = "11",
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    Bossink, EGBM, Henry, OYF, Benz, MA, Segerink, L, Ingber, DE & Odijk, M 2018, A miniaturized clark oxygen sensor for organ-on-chip devices. in MicroTAS 2018: 22nd International Conference on Miniaturized Systems for Chemistry and Life Science. pp. 889-892, 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2018, Kaohsiung, Taiwan, Province of China, 10/11/18.

    A miniaturized clark oxygen sensor for organ-on-chip devices. / Bossink, Elsbeth G.B.M.; Henry, Olivier Y.F. ; Benz, Maximilian A.; Segerink, Loes; Ingber, Donald E.; Odijk, Mathieu .

    MicroTAS 2018: 22nd International Conference on Miniaturized Systems for Chemistry and Life Science. 2018. p. 889-892.

    Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

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    AU - Bossink, Elsbeth G.B.M.

    AU - Henry, Olivier Y.F.

    AU - Benz, Maximilian A.

    AU - Segerink, Loes

    AU - Ingber, Donald E.

    AU - Odijk, Mathieu

    PY - 2018/11/11

    Y1 - 2018/11/11

    N2 - Oxygen concentration is an essential regulatory parameter in cell culture and organ-on-chip devices. Measuring variations in oxygen concentration near cells during cell culture can provide a wealth of information on cell viability, cellular activity, cell differentiation and response to external stimuli. Here, we present a miniaturized three-electrode Clark oxygen sensor, which is shown to be biocompatible, protected from biofouling and has a 7.5s response time. This miniaturized sensor allows to measure the oxygen concentration in a microfluidic channel of an organ-on-chip, whereby this chemical microenvironment can be monitored.

    AB - Oxygen concentration is an essential regulatory parameter in cell culture and organ-on-chip devices. Measuring variations in oxygen concentration near cells during cell culture can provide a wealth of information on cell viability, cellular activity, cell differentiation and response to external stimuli. Here, we present a miniaturized three-electrode Clark oxygen sensor, which is shown to be biocompatible, protected from biofouling and has a 7.5s response time. This miniaturized sensor allows to measure the oxygen concentration in a microfluidic channel of an organ-on-chip, whereby this chemical microenvironment can be monitored.

    KW - Clark oxygen sensor

    KW - Miniaturization

    KW - Oxygen concentration

    KW - Organ-on-a-chip

    M3 - Conference contribution

    SN - 978-0-578-40530-8

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    BT - MicroTAS 2018

    ER -

    Bossink EGBM, Henry OYF, Benz MA, Segerink L, Ingber DE, Odijk M. A miniaturized clark oxygen sensor for organ-on-chip devices. In MicroTAS 2018: 22nd International Conference on Miniaturized Systems for Chemistry and Life Science. 2018. p. 889-892