A miniaturized clark oxygen sensor for organ-on-chip devices

Elsbeth G.B.M. Bossink; Olivier Y.F.  Henry; Maximilian A. Benz; Loes Segerink; Donald E. Ingber; Mathieu  Odijk

A miniaturized clark oxygen sensor for organ-on-chip devices

Elsbeth G.B.M. Bossink, Olivier Y.F. Henry, Maximilian A. Benz, Loes Segerink, Donald E. Ingber, Mathieu Odijk

Biomedical and Environmental Sensorsystems

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

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Abstract

Oxygen concentration is an essential regulatory parameter in cell culture and organ-on-chip devices. Measuring variations in oxygen concentration near cells during cell culture can provide a wealth of information on cell viability, cellular activity, cell differentiation and response to external stimuli. Here, we present a miniaturized three-electrode Clark oxygen sensor, which is shown to be biocompatible, protected from biofouling and has a 7.5s response time. This miniaturized sensor allows to measure the oxygen concentration in a microfluidic channel of an organ-on-chip, whereby this chemical microenvironment can be monitored.

Original language	English
Title of host publication	MicroTAS 2018
Subtitle of host publication	22nd International Conference on Miniaturized Systems for Chemistry and Life Science
Editors	Fan-Gang Tseng, Gwo-Bin Lee
Publisher	The Chemical and Biological Microsystems Society
Pages	889-892
Number of pages	4
ISBN (Electronic)	978-1-510-89757-1
ISBN (Print)	978-0-578-40530-8
Publication status	Published - 11 Nov 2018
Event	22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2018 - Kaohsiung Exhibition Center, Kaohsiung, Taiwan Duration: 10 Nov 2018 → 15 Nov 2018 Conference number: 22 https://cbmsociety.org/conferences/microtas2018/

Conference

Conference	22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2018
Abbreviated title	MicroTAS 2018
Country/Territory	Taiwan
City	Kaohsiung
Period	10/11/18 → 15/11/18
Internet address	https://cbmsociety.org/conferences/microtas2018/

Keywords

Clark oxygen sensor
Miniaturization
Oxygen concentration
Organ-on-a-chip

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@inproceedings{b76149d7f183470e8211e131b9e7294f,

title = "A miniaturized clark oxygen sensor for organ-on-chip devices",

abstract = "Oxygen concentration is an essential regulatory parameter in cell culture and organ-on-chip devices. Measuring variations in oxygen concentration near cells during cell culture can provide a wealth of information on cell viability, cellular activity, cell differentiation and response to external stimuli. Here, we present a miniaturized three-electrode Clark oxygen sensor, which is shown to be biocompatible, protected from biofouling and has a 7.5s response time. This miniaturized sensor allows to measure the oxygen concentration in a microfluidic channel of an organ-on-chip, whereby this chemical microenvironment can be monitored.",

keywords = "Clark oxygen sensor, Miniaturization, Oxygen concentration, Organ-on-a-chip",

author = "Bossink, {Elsbeth G.B.M.} and Henry, {Olivier Y.F.} and Benz, {Maximilian A.} and Loes Segerink and Ingber, {Donald E.} and Mathieu Odijk",

year = "2018",

month = nov,

day = "11",

language = "English",

isbn = "978-0-578-40530-8",

pages = "889--892",

editor = "Fan-Gang Tseng and Gwo-Bin Lee",

booktitle = "MicroTAS 2018",

publisher = "The Chemical and Biological Microsystems Society",

note = "22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2018, MicroTAS 2018 ; Conference date: 10-11-2018 Through 15-11-2018",

url = "https://cbmsociety.org/conferences/microtas2018/",

}

Bossink, EGBM, Henry, OYF, Benz, MA, Segerink, L, Ingber, DE & Odijk, M 2018, A miniaturized clark oxygen sensor for organ-on-chip devices. in F-G Tseng & G-B Lee (eds), MicroTAS 2018: 22nd International Conference on Miniaturized Systems for Chemistry and Life Science. The Chemical and Biological Microsystems Society, pp. 889-892, 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2018, Kaohsiung, Taiwan, 10/11/18.

A miniaturized clark oxygen sensor for organ-on-chip devices. / Bossink, Elsbeth G.B.M.; Henry, Olivier Y.F. ; Benz, Maximilian A. et al.
MicroTAS 2018: 22nd International Conference on Miniaturized Systems for Chemistry and Life Science. ed. / Fan-Gang Tseng; Gwo-Bin Lee. The Chemical and Biological Microsystems Society, 2018. p. 889-892.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

TY - GEN

T1 - A miniaturized clark oxygen sensor for organ-on-chip devices

AU - Bossink, Elsbeth G.B.M.

AU - Henry, Olivier Y.F.

AU - Benz, Maximilian A.

AU - Segerink, Loes

AU - Ingber, Donald E.

AU - Odijk, Mathieu

N1 - Conference code: 22

PY - 2018/11/11

Y1 - 2018/11/11

N2 - Oxygen concentration is an essential regulatory parameter in cell culture and organ-on-chip devices. Measuring variations in oxygen concentration near cells during cell culture can provide a wealth of information on cell viability, cellular activity, cell differentiation and response to external stimuli. Here, we present a miniaturized three-electrode Clark oxygen sensor, which is shown to be biocompatible, protected from biofouling and has a 7.5s response time. This miniaturized sensor allows to measure the oxygen concentration in a microfluidic channel of an organ-on-chip, whereby this chemical microenvironment can be monitored.

AB - Oxygen concentration is an essential regulatory parameter in cell culture and organ-on-chip devices. Measuring variations in oxygen concentration near cells during cell culture can provide a wealth of information on cell viability, cellular activity, cell differentiation and response to external stimuli. Here, we present a miniaturized three-electrode Clark oxygen sensor, which is shown to be biocompatible, protected from biofouling and has a 7.5s response time. This miniaturized sensor allows to measure the oxygen concentration in a microfluidic channel of an organ-on-chip, whereby this chemical microenvironment can be monitored.

KW - Clark oxygen sensor

KW - Miniaturization

KW - Oxygen concentration

KW - Organ-on-a-chip

M3 - Conference contribution

SN - 978-0-578-40530-8

SP - 889

EP - 892

BT - MicroTAS 2018

A2 - Tseng, Fan-Gang

A2 - Lee, Gwo-Bin

PB - The Chemical and Biological Microsystems Society

T2 - 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2018

Y2 - 10 November 2018 through 15 November 2018

ER -

A miniaturized clark oxygen sensor for organ-on-chip devices

Abstract

Conference

Keywords

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Cite this