Crown[n]cavitands were synthesized by alkylation of tetrahydroxycavitands with polyethyleneglycol ditosylates. The bridging of two hydroxy groups at adjacent aromatic rings by a pentaethyleneglycol unit is favored over the bridging of two hydroxy groups at opposite aromatic rings. The presence of a sodium base enhances the formation of the 1,2-crown[n]cavitand and improves the yield. The combination of 1,2-crowncavitands with calixarenes or resorcinarenes resulted in potential receptor molecules with large hydrophobic surfaces.
|Journal||European journal of organic chemistry|
|Publication status||Published - 1998|
- Modular approach
- Crown compounds
- Building blocks
Higler, I., Higler, I., Boerrigter, H., Verboom, W., Kooijman, H., Spek, A. L., & Reinhoudt, D. (1998). A modular approach to potential synthetic receptors with large surfaces based on crown[n]cavitands. European journal of organic chemistry, 1998(8), 1597-1607. https://doi.org/10.1002/(SICI)1099-0690(199808)1998:8<1597::AID-EJOC1597>3.0.CO;2-1