A non-fouling surface containing immobilized polyethylene oxide (PEO) was achieved using an argon radio-frequency glow discharge treatment (RFGD) of polyethylene films precoated with Brij hydrocarbon-PEO surfactants. Surface wettability of RFGD-treated and washed surfaces increased the most when PEO surfactants with unsaturated and/or long alkyl tails were used. ESCA measurements of treated and washed surfaces showed increases of surface O/C ratios and ether carbon peaks in high resolution Cls spectra. These results demonstrate the retention of the PEO surfactants on the treated surfaces. Fibrinogen adsorp tion on these treated surfaces was significantly reduced, from 500 to 50 ng/cm2, indicating the non-fouling properties of the RFGD-immobilized PEO surfactants.