A new selection method to increase the health benefits of CVD prevention strategies

Ghizelda R. Lagerweij* (Corresponding Author), G. Ardine de Wit, Karel G.M. Moons, Yvonne T. van der Schouw, W.M. Monique Verschuren, Jannick A.N. Dorresteijn, Hendrik Koffijberg

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)
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Abstract

Background: Cardiovascular disease (CVD) prevention is commonly focused on providing individuals at high predicted CVD risk with preventive medication. Whereas CVD risk increases rapidly with age, current risk-based selection of individuals mainly targets the elderly. However, the lifelong (preventable) consequences of CVD events may be larger in younger individuals. The purpose of this paper is to investigate if health benefits from preventive treatment may increase when the selection strategy is further optimised.

Methods: Data from three Dutch cohorts were combined (n=47469, men:women 1:1.92) and classified into subgroups based on age and gender. The Framingham global risk score was used to estimate 10-year CVD risk. The associated lifelong burden of CVD events according to this 10-year CVD risk was expressed as quality-adjusted life years lost. Based on this approach, the additional health benefits from preventive treatment, reducing this 10-year CVD risk, from selecting individuals based on their expected CVD burden rather than their expected CVD risk were estimated. These benefits were expressed as quality-adjusted life years gained over lifetime.

Results: When using the current selection strategy (10% risk threshold), 32% of the individuals were selected for preventive treatment. When the same proportion was selected based on burden, more younger and fewer older individuals would receive treatment. Across all individuals, the gain in quality-adjusted life years was 217 between the two strategies, over a 10-year time horizon. In addition, when combining the strategies 5% extra eligible individuals were selected resulting in a gain of 628 quality-adjusted life years.

Conclusion: Improvement of the selection approach of individuals can help to reduce further the CVD burden. Selecting individuals for preventive treatment based on their expected CVD burden will provide more younger and fewer older individuals with treatment, and will reduce the overall CVD burden.

Original languageEnglish
Pages (from-to)642-650
Number of pages9
JournalEuropean journal of preventive cardiology
Volume25
Issue number6
DOIs
Publication statusPublished - Apr 2018

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Insurance Benefits
Cardiovascular Diseases
Quality-Adjusted Life Years
Therapeutics

Keywords

  • UT-Hybrid-D
  • Cardiovascular disease
  • Prevention
  • Public health
  • Risk prediction
  • Burden of disease

Cite this

Lagerweij, G. R., de Wit, G. A., Moons, K. G. M., van der Schouw, Y. T., Verschuren, W. M. M., Dorresteijn, J. A. N., & Koffijberg, H. (2018). A new selection method to increase the health benefits of CVD prevention strategies. European journal of preventive cardiology, 25(6), 642-650. https://doi.org/10.1177/2047487317752948
Lagerweij, Ghizelda R. ; de Wit, G. Ardine ; Moons, Karel G.M. ; van der Schouw, Yvonne T. ; Verschuren, W.M. Monique ; Dorresteijn, Jannick A.N. ; Koffijberg, Hendrik. / A new selection method to increase the health benefits of CVD prevention strategies. In: European journal of preventive cardiology. 2018 ; Vol. 25, No. 6. pp. 642-650.
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abstract = "Background: Cardiovascular disease (CVD) prevention is commonly focused on providing individuals at high predicted CVD risk with preventive medication. Whereas CVD risk increases rapidly with age, current risk-based selection of individuals mainly targets the elderly. However, the lifelong (preventable) consequences of CVD events may be larger in younger individuals. The purpose of this paper is to investigate if health benefits from preventive treatment may increase when the selection strategy is further optimised.Methods: Data from three Dutch cohorts were combined (n=47469, men:women 1:1.92) and classified into subgroups based on age and gender. The Framingham global risk score was used to estimate 10-year CVD risk. The associated lifelong burden of CVD events according to this 10-year CVD risk was expressed as quality-adjusted life years lost. Based on this approach, the additional health benefits from preventive treatment, reducing this 10-year CVD risk, from selecting individuals based on their expected CVD burden rather than their expected CVD risk were estimated. These benefits were expressed as quality-adjusted life years gained over lifetime.Results: When using the current selection strategy (10{\%} risk threshold), 32{\%} of the individuals were selected for preventive treatment. When the same proportion was selected based on burden, more younger and fewer older individuals would receive treatment. Across all individuals, the gain in quality-adjusted life years was 217 between the two strategies, over a 10-year time horizon. In addition, when combining the strategies 5{\%} extra eligible individuals were selected resulting in a gain of 628 quality-adjusted life years.Conclusion: Improvement of the selection approach of individuals can help to reduce further the CVD burden. Selecting individuals for preventive treatment based on their expected CVD burden will provide more younger and fewer older individuals with treatment, and will reduce the overall CVD burden.",
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Lagerweij, GR, de Wit, GA, Moons, KGM, van der Schouw, YT, Verschuren, WMM, Dorresteijn, JAN & Koffijberg, H 2018, 'A new selection method to increase the health benefits of CVD prevention strategies', European journal of preventive cardiology, vol. 25, no. 6, pp. 642-650. https://doi.org/10.1177/2047487317752948

A new selection method to increase the health benefits of CVD prevention strategies. / Lagerweij, Ghizelda R. (Corresponding Author); de Wit, G. Ardine; Moons, Karel G.M.; van der Schouw, Yvonne T.; Verschuren, W.M. Monique; Dorresteijn, Jannick A.N.; Koffijberg, Hendrik.

In: European journal of preventive cardiology, Vol. 25, No. 6, 04.2018, p. 642-650.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - A new selection method to increase the health benefits of CVD prevention strategies

AU - Lagerweij, Ghizelda R.

AU - de Wit, G. Ardine

AU - Moons, Karel G.M.

AU - van der Schouw, Yvonne T.

AU - Verschuren, W.M. Monique

AU - Dorresteijn, Jannick A.N.

AU - Koffijberg, Hendrik

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N2 - Background: Cardiovascular disease (CVD) prevention is commonly focused on providing individuals at high predicted CVD risk with preventive medication. Whereas CVD risk increases rapidly with age, current risk-based selection of individuals mainly targets the elderly. However, the lifelong (preventable) consequences of CVD events may be larger in younger individuals. The purpose of this paper is to investigate if health benefits from preventive treatment may increase when the selection strategy is further optimised.Methods: Data from three Dutch cohorts were combined (n=47469, men:women 1:1.92) and classified into subgroups based on age and gender. The Framingham global risk score was used to estimate 10-year CVD risk. The associated lifelong burden of CVD events according to this 10-year CVD risk was expressed as quality-adjusted life years lost. Based on this approach, the additional health benefits from preventive treatment, reducing this 10-year CVD risk, from selecting individuals based on their expected CVD burden rather than their expected CVD risk were estimated. These benefits were expressed as quality-adjusted life years gained over lifetime.Results: When using the current selection strategy (10% risk threshold), 32% of the individuals were selected for preventive treatment. When the same proportion was selected based on burden, more younger and fewer older individuals would receive treatment. Across all individuals, the gain in quality-adjusted life years was 217 between the two strategies, over a 10-year time horizon. In addition, when combining the strategies 5% extra eligible individuals were selected resulting in a gain of 628 quality-adjusted life years.Conclusion: Improvement of the selection approach of individuals can help to reduce further the CVD burden. Selecting individuals for preventive treatment based on their expected CVD burden will provide more younger and fewer older individuals with treatment, and will reduce the overall CVD burden.

AB - Background: Cardiovascular disease (CVD) prevention is commonly focused on providing individuals at high predicted CVD risk with preventive medication. Whereas CVD risk increases rapidly with age, current risk-based selection of individuals mainly targets the elderly. However, the lifelong (preventable) consequences of CVD events may be larger in younger individuals. The purpose of this paper is to investigate if health benefits from preventive treatment may increase when the selection strategy is further optimised.Methods: Data from three Dutch cohorts were combined (n=47469, men:women 1:1.92) and classified into subgroups based on age and gender. The Framingham global risk score was used to estimate 10-year CVD risk. The associated lifelong burden of CVD events according to this 10-year CVD risk was expressed as quality-adjusted life years lost. Based on this approach, the additional health benefits from preventive treatment, reducing this 10-year CVD risk, from selecting individuals based on their expected CVD burden rather than their expected CVD risk were estimated. These benefits were expressed as quality-adjusted life years gained over lifetime.Results: When using the current selection strategy (10% risk threshold), 32% of the individuals were selected for preventive treatment. When the same proportion was selected based on burden, more younger and fewer older individuals would receive treatment. Across all individuals, the gain in quality-adjusted life years was 217 between the two strategies, over a 10-year time horizon. In addition, when combining the strategies 5% extra eligible individuals were selected resulting in a gain of 628 quality-adjusted life years.Conclusion: Improvement of the selection approach of individuals can help to reduce further the CVD burden. Selecting individuals for preventive treatment based on their expected CVD burden will provide more younger and fewer older individuals with treatment, and will reduce the overall CVD burden.

KW - UT-Hybrid-D

KW - Cardiovascular disease

KW - Prevention

KW - Public health

KW - Risk prediction

KW - Burden of disease

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DO - 10.1177/2047487317752948

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Lagerweij GR, de Wit GA, Moons KGM, van der Schouw YT, Verschuren WMM, Dorresteijn JAN et al. A new selection method to increase the health benefits of CVD prevention strategies. European journal of preventive cardiology. 2018 Apr;25(6):642-650. https://doi.org/10.1177/2047487317752948