TY - JOUR
T1 - A novel approach in extracorporeal circulation
T2 - Individual, integrated, and interactive heart-lung assist (I3-Assist)
AU - Wagner, Georg
AU - Schlanstein, Peter
AU - Fiehe, Sandra
AU - Kaufmann, Tim
AU - Kopp, Rüdger
AU - Bensberg, Ralf
AU - Schmitz-Rode, Thomas
AU - Steinseifer, Ulrich
AU - Arens, Jutta
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Extracorporeal life support (ECLS) is a wellestablished technique for the treatment of different cardiac and pulmonary diseases, e.g., congenital heart disease and acute respiratory distress syndrome. Additionally, severely ill patients who cannot be weaned from the heart-lung machine directly after surgery have to be put on ECLS for further therapy. Although both systems include identical components, a seamless transition is not possible yet. The adaption of the circuit to the patients' size and demand is limited owing to the components available. The project I3-Assist aims at a novel concept for extracorporeal circulation. To better match the patient's therapeutic demand of support, an individual number of one-size oxygenators and heat exchangers will be combined. A seamless transition between cardiopulmonary bypass and ECLS will be possible as well as the exchange of components during therapy to enhance circuit maintenance throughout long-term support. Until today, a novel oxygenator and heat exchanger along with a simplified manufacturing protocol have been established. The first layouts of the unit to allow the spill- and bubble- free connection and disconnection of modules as well as improved cannulas and a rotational pump are investigated using computational fluid dynamics. Tests were performed according to current guidelines in vitro and in vivo. The test results show the feasibility and potential of the concept.
AB - Extracorporeal life support (ECLS) is a wellestablished technique for the treatment of different cardiac and pulmonary diseases, e.g., congenital heart disease and acute respiratory distress syndrome. Additionally, severely ill patients who cannot be weaned from the heart-lung machine directly after surgery have to be put on ECLS for further therapy. Although both systems include identical components, a seamless transition is not possible yet. The adaption of the circuit to the patients' size and demand is limited owing to the components available. The project I3-Assist aims at a novel concept for extracorporeal circulation. To better match the patient's therapeutic demand of support, an individual number of one-size oxygenators and heat exchangers will be combined. A seamless transition between cardiopulmonary bypass and ECLS will be possible as well as the exchange of components during therapy to enhance circuit maintenance throughout long-term support. Until today, a novel oxygenator and heat exchanger along with a simplified manufacturing protocol have been established. The first layouts of the unit to allow the spill- and bubble- free connection and disconnection of modules as well as improved cannulas and a rotational pump are investigated using computational fluid dynamics. Tests were performed according to current guidelines in vitro and in vivo. The test results show the feasibility and potential of the concept.
KW - ECLS
KW - HLM
KW - Individual therapy
KW - Modular design
KW - Normative testing
UR - http://www.scopus.com/inward/record.url?scp=84903594133&partnerID=8YFLogxK
U2 - 10.1515/bmt-2013-0026
DO - 10.1515/bmt-2013-0026
M3 - Article
C2 - 24327525
AN - SCOPUS:84903594133
VL - 59
SP - 125
EP - 133
JO - Biomedical engineering = Biomedizinische Technik
JF - Biomedical engineering = Biomedizinische Technik
SN - 0013-5585
IS - 2
ER -