A novel honey-based nanofibrous scaffold for wound dressing application

H. Maleki, A. A. Gharehaghaji*, P. J. Dijkstra

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

53 Citations (Scopus)

Abstract

In this study, nanofiber meshes were produced from aqueous mixtures of poly(vinyl alcohol) (PVA) and honey via electrospinning. The Electrospinning process was performed at different PVAs to honey ratios (100/0, 90/10, 80/20, 70/30, and 60/40). Dexamethasone sodium phosphate was selected as an anti-inflammatory drug and incorporated in the electrospinning solutions. Its release behavior was determined. Uniform and smooth nanofibers were formed, independent of the honey content. In case honey content increased up to 40%, some spindle-like beads on the fibers were observed. The diameter of electrospun fibers decreased as the ratio of honey increased. The release characteristics of the model drug from both the PVA and PVA/honey (80/20) nanofibrous mats were studied and statistical analysis was performed. All electrospun fibers exhibited a large initial burst release at a short time after incubation. The release profile was similar for both PVA and PVA/honey (80/20) drug-loaded nanofibers. This study shows that an anti-inflammatory drug can be released during the initial stages and honey can be used as a natural antibiotic to improve the wound dressing efficiency and increase the healing rate.

Original languageEnglish
Pages (from-to)4086-4092
Number of pages7
JournalJournal of applied polymer science
Volume127
Issue number5
DOIs
Publication statusPublished - 5 Mar 2013

Keywords

  • drug release
  • electrospinning
  • honey
  • nanofiber
  • wound dressing

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