A novel method to transfer porous PDMS membranes for high throughput Organ-on-Chip and Lab-on-Chip assembly

W. F. Quiros-Solano; N. Gaio; C. Silvestri; Y. B. Arik; O. M.J.A. Stassen; A. D. Van Der Meer; C.V.C. Bouten; A. Van Den Berg; R. Dekker; P.M. Sarro

doi:10.1109/MEMSYS.2018.8346550

A novel method to transfer porous PDMS membranes for high throughput Organ-on-Chip and Lab-on-Chip assembly

W. F. Quiros-Solano^*, N. Gaio, C. Silvestri, Y. B. Arik, O. M.J.A. Stassen, A. D. Van Der Meer, C.V.C. Bouten, A. Van Den Berg, R. Dekker, P.M. Sarro

^*Corresponding author for this work

Applied Stem Cell Technologies

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

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Abstract

We present a novel method to easily and reliably transfer highly porous, large area, thin microfabricated Polydimethylsiloxane (PDMS) porous membranes on Lab-on-Chip (LOC) and Organ-on-Chip (OOC) devices. The use of silicon as carrier substrate and a water-soluble sacrificial layer allows a simple and reproducible transfer of the membranes to any PDMS-based OOC and LOC device. The use of IC and MEMS compatible techniques reduces significantly the fabrication time and the need of manual handling. Our method is suitable for automatic assembling systems, such as pick-and-place, crucial to significantly increase the throughput of OOC and LOC devices assembling. Membranes with 8 μm pore size and as thin as 4 μm are successfully transferred. The viability and biocompatibility of the transfer was assessed by culturing two different cell lines on an OOC with transferred porous PDMS membranes.

Original language	English
Title of host publication	2018 IEEE Micro Electro Mechanical Systems, MEMS 2018
Publisher	IEEE
Pages	318-321
Number of pages	4
Volume	2018-January
ISBN (Electronic)	9781538647820
ISBN (Print)	9781538647820
DOIs	https://doi.org/10.1109/MEMSYS.2018.8346550
Publication status	Published - 24 Apr 2018
Event	31st IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2018 - Belfast Waterfront, Belfast, United Kingdom Duration: 21 Jan 2018 → 25 Jan 2018 Conference number: 31 http://www.mems2018.org/

Publication series

Name	Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
Volume	2018-January

Conference

Conference	31st IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2018
Abbreviated title	MEMS
Country/Territory	United Kingdom
City	Belfast
Period	21/01/18 → 25/01/18
Internet address	http://www.mems2018.org/

Keywords

2019 OA procedure

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10.1109/MEMSYS.2018.8346550

Quiros-Solano2018novelFinal published version, 705 KBLicence: Taverne

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Quiros-Solano, W. F., Gaio, N., Silvestri, C., Arik, Y. B., Stassen, O. M. J. A., Van Der Meer, A. D., Bouten, C. V. C., Van Den Berg, A., Dekker, R., & Sarro, P. M. (2018). A novel method to transfer porous PDMS membranes for high throughput Organ-on-Chip and Lab-on-Chip assembly. In 2018 IEEE Micro Electro Mechanical Systems, MEMS 2018 (Vol. 2018-January, pp. 318-321). (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS); Vol. 2018-January). IEEE. https://doi.org/10.1109/MEMSYS.2018.8346550

@inproceedings{ed2809af8f5b432b8f16afc4e5e1bff8,

title = "A novel method to transfer porous PDMS membranes for high throughput Organ-on-Chip and Lab-on-Chip assembly",

abstract = "We present a novel method to easily and reliably transfer highly porous, large area, thin microfabricated Polydimethylsiloxane (PDMS) porous membranes on Lab-on-Chip (LOC) and Organ-on-Chip (OOC) devices. The use of silicon as carrier substrate and a water-soluble sacrificial layer allows a simple and reproducible transfer of the membranes to any PDMS-based OOC and LOC device. The use of IC and MEMS compatible techniques reduces significantly the fabrication time and the need of manual handling. Our method is suitable for automatic assembling systems, such as pick-and-place, crucial to significantly increase the throughput of OOC and LOC devices assembling. Membranes with 8 μm pore size and as thin as 4 μm are successfully transferred. The viability and biocompatibility of the transfer was assessed by culturing two different cell lines on an OOC with transferred porous PDMS membranes.",

keywords = "2019 OA procedure",

author = "Quiros-Solano, {W. F.} and N. Gaio and C. Silvestri and Arik, {Y. B.} and Stassen, {O. M.J.A.} and {Van Der Meer}, {A. D.} and C.V.C. Bouten and {Van Den Berg}, A. and R. Dekker and P.M. Sarro",

year = "2018",

month = apr,

day = "24",

doi = "10.1109/MEMSYS.2018.8346550",

language = "English",

isbn = "9781538647820",

volume = "2018-January",

series = "Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)",

publisher = "IEEE",

pages = "318--321",

booktitle = "2018 IEEE Micro Electro Mechanical Systems, MEMS 2018",

address = "United States",

note = "31st IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2018, MEMS ; Conference date: 21-01-2018 Through 25-01-2018",

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Quiros-Solano, WF, Gaio, N, Silvestri, C, Arik, YB, Stassen, OMJA, Van Der Meer, AD, Bouten, CVC, Van Den Berg, A, Dekker, R & Sarro, PM 2018, A novel method to transfer porous PDMS membranes for high throughput Organ-on-Chip and Lab-on-Chip assembly. in 2018 IEEE Micro Electro Mechanical Systems, MEMS 2018. vol. 2018-January, Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS), vol. 2018-January, IEEE, pp. 318-321, 31st IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2018, Belfast, United Kingdom, 21/01/18. https://doi.org/10.1109/MEMSYS.2018.8346550

A novel method to transfer porous PDMS membranes for high throughput Organ-on-Chip and Lab-on-Chip assembly. / Quiros-Solano, W. F.; Gaio, N.; Silvestri, C. et al.
2018 IEEE Micro Electro Mechanical Systems, MEMS 2018. Vol. 2018-January IEEE, 2018. p. 318-321 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS); Vol. 2018-January).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

TY - GEN

T1 - A novel method to transfer porous PDMS membranes for high throughput Organ-on-Chip and Lab-on-Chip assembly

AU - Quiros-Solano, W. F.

AU - Gaio, N.

AU - Silvestri, C.

AU - Arik, Y. B.

AU - Stassen, O. M.J.A.

AU - Van Der Meer, A. D.

AU - Bouten, C.V.C.

AU - Van Den Berg, A.

AU - Dekker, R.

AU - Sarro, P.M.

N1 - Conference code: 31

PY - 2018/4/24

Y1 - 2018/4/24

N2 - We present a novel method to easily and reliably transfer highly porous, large area, thin microfabricated Polydimethylsiloxane (PDMS) porous membranes on Lab-on-Chip (LOC) and Organ-on-Chip (OOC) devices. The use of silicon as carrier substrate and a water-soluble sacrificial layer allows a simple and reproducible transfer of the membranes to any PDMS-based OOC and LOC device. The use of IC and MEMS compatible techniques reduces significantly the fabrication time and the need of manual handling. Our method is suitable for automatic assembling systems, such as pick-and-place, crucial to significantly increase the throughput of OOC and LOC devices assembling. Membranes with 8 μm pore size and as thin as 4 μm are successfully transferred. The viability and biocompatibility of the transfer was assessed by culturing two different cell lines on an OOC with transferred porous PDMS membranes.

AB - We present a novel method to easily and reliably transfer highly porous, large area, thin microfabricated Polydimethylsiloxane (PDMS) porous membranes on Lab-on-Chip (LOC) and Organ-on-Chip (OOC) devices. The use of silicon as carrier substrate and a water-soluble sacrificial layer allows a simple and reproducible transfer of the membranes to any PDMS-based OOC and LOC device. The use of IC and MEMS compatible techniques reduces significantly the fabrication time and the need of manual handling. Our method is suitable for automatic assembling systems, such as pick-and-place, crucial to significantly increase the throughput of OOC and LOC devices assembling. Membranes with 8 μm pore size and as thin as 4 μm are successfully transferred. The viability and biocompatibility of the transfer was assessed by culturing two different cell lines on an OOC with transferred porous PDMS membranes.

KW - 2019 OA procedure

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U2 - 10.1109/MEMSYS.2018.8346550

DO - 10.1109/MEMSYS.2018.8346550

M3 - Conference contribution

AN - SCOPUS:85047015523

SN - 9781538647820

VL - 2018-January

T3 - Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)

SP - 318

EP - 321

BT - 2018 IEEE Micro Electro Mechanical Systems, MEMS 2018

PB - IEEE

T2 - 31st IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2018

Y2 - 21 January 2018 through 25 January 2018

ER -

Quiros-Solano WF, Gaio N, Silvestri C, Arik YB, Stassen OMJA, Van Der Meer AD et al. A novel method to transfer porous PDMS membranes for high throughput Organ-on-Chip and Lab-on-Chip assembly. In 2018 IEEE Micro Electro Mechanical Systems, MEMS 2018. Vol. 2018-January. IEEE. 2018. p. 318-321. (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)). doi: 10.1109/MEMSYS.2018.8346550

A novel method to transfer porous PDMS membranes for high throughput Organ-on-Chip and Lab-on-Chip assembly

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