A novel method to transfer porous PDMS membranes for high throughput Organ-on-Chip and Lab-on-Chip assembly

W. F. Quiros-Solano, N. Gaio, C. Silvestri, Y. B. Arik, O. M.J.A. Stassen, A. D. Van Der Meer, C.V.C. Bouten, A. Van Den Berg, R. Dekker, P.M. Sarro

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Abstract

We present a novel method to easily and reliably transfer highly porous, large area, thin microfabricated Polydimethylsiloxane (PDMS) porous membranes on Lab-on-Chip (LOC) and Organ-on-Chip (OOC) devices. The use of silicon as carrier substrate and a water-soluble sacrificial layer allows a simple and reproducible transfer of the membranes to any PDMS-based OOC and LOC device. The use of IC and MEMS compatible techniques reduces significantly the fabrication time and the need of manual handling. Our method is suitable for automatic assembling systems, such as pick-and-place, crucial to significantly increase the throughput of OOC and LOC devices assembling. Membranes with 8 μm pore size and as thin as 4 μm are successfully transferred. The viability and biocompatibility of the transfer was assessed by culturing two different cell lines on an OOC with transferred porous PDMS membranes.

Original languageEnglish
Title of host publication2018 IEEE Micro Electro Mechanical Systems, MEMS 2018
PublisherIEEE
Pages318-321
Number of pages4
Volume2018-January
ISBN (Electronic)9781538647820
ISBN (Print)9781538647820
DOIs
Publication statusPublished - 24 Apr 2018
Event31st IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2018 - Belfast Waterfront, Belfast, United Kingdom
Duration: 21 Jan 201825 Jan 2018
Conference number: 31
http://www.mems2018.org/

Publication series

NameProceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
Volume2018-January

Conference

Conference31st IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2018
Abbreviated titleMEMS
CountryUnited Kingdom
CityBelfast
Period21/01/1825/01/18
Internet address

Fingerprint

Polydimethylsiloxane
organs
assembly
chips
Throughput
membranes
Membranes
assembling
Silicon
Biocompatibility
Pore size
MEMS
Cells
Fabrication
biocompatibility
baysilon
Water
cultured cells
viability
Substrates

Cite this

Quiros-Solano, W. F., Gaio, N., Silvestri, C., Arik, Y. B., Stassen, O. M. J. A., Van Der Meer, A. D., ... Sarro, P. M. (2018). A novel method to transfer porous PDMS membranes for high throughput Organ-on-Chip and Lab-on-Chip assembly. In 2018 IEEE Micro Electro Mechanical Systems, MEMS 2018 (Vol. 2018-January, pp. 318-321). (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS); Vol. 2018-January). IEEE. https://doi.org/10.1109/MEMSYS.2018.8346550
Quiros-Solano, W. F. ; Gaio, N. ; Silvestri, C. ; Arik, Y. B. ; Stassen, O. M.J.A. ; Van Der Meer, A. D. ; Bouten, C.V.C. ; Van Den Berg, A. ; Dekker, R. ; Sarro, P.M. / A novel method to transfer porous PDMS membranes for high throughput Organ-on-Chip and Lab-on-Chip assembly. 2018 IEEE Micro Electro Mechanical Systems, MEMS 2018. Vol. 2018-January IEEE, 2018. pp. 318-321 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)).
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abstract = "We present a novel method to easily and reliably transfer highly porous, large area, thin microfabricated Polydimethylsiloxane (PDMS) porous membranes on Lab-on-Chip (LOC) and Organ-on-Chip (OOC) devices. The use of silicon as carrier substrate and a water-soluble sacrificial layer allows a simple and reproducible transfer of the membranes to any PDMS-based OOC and LOC device. The use of IC and MEMS compatible techniques reduces significantly the fabrication time and the need of manual handling. Our method is suitable for automatic assembling systems, such as pick-and-place, crucial to significantly increase the throughput of OOC and LOC devices assembling. Membranes with 8 μm pore size and as thin as 4 μm are successfully transferred. The viability and biocompatibility of the transfer was assessed by culturing two different cell lines on an OOC with transferred porous PDMS membranes.",
author = "Quiros-Solano, {W. F.} and N. Gaio and C. Silvestri and Arik, {Y. B.} and Stassen, {O. M.J.A.} and {Van Der Meer}, {A. D.} and C.V.C. Bouten and {Van Den Berg}, A. and R. Dekker and P.M. Sarro",
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Quiros-Solano, WF, Gaio, N, Silvestri, C, Arik, YB, Stassen, OMJA, Van Der Meer, AD, Bouten, CVC, Van Den Berg, A, Dekker, R & Sarro, PM 2018, A novel method to transfer porous PDMS membranes for high throughput Organ-on-Chip and Lab-on-Chip assembly. in 2018 IEEE Micro Electro Mechanical Systems, MEMS 2018. vol. 2018-January, Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS), vol. 2018-January, IEEE, pp. 318-321, 31st IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2018, Belfast, United Kingdom, 21/01/18. https://doi.org/10.1109/MEMSYS.2018.8346550

A novel method to transfer porous PDMS membranes for high throughput Organ-on-Chip and Lab-on-Chip assembly. / Quiros-Solano, W. F.; Gaio, N.; Silvestri, C.; Arik, Y. B.; Stassen, O. M.J.A.; Van Der Meer, A. D.; Bouten, C.V.C.; Van Den Berg, A.; Dekker, R.; Sarro, P.M.

2018 IEEE Micro Electro Mechanical Systems, MEMS 2018. Vol. 2018-January IEEE, 2018. p. 318-321 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS); Vol. 2018-January).

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

TY - GEN

T1 - A novel method to transfer porous PDMS membranes for high throughput Organ-on-Chip and Lab-on-Chip assembly

AU - Quiros-Solano, W. F.

AU - Gaio, N.

AU - Silvestri, C.

AU - Arik, Y. B.

AU - Stassen, O. M.J.A.

AU - Van Der Meer, A. D.

AU - Bouten, C.V.C.

AU - Van Den Berg, A.

AU - Dekker, R.

AU - Sarro, P.M.

PY - 2018/4/24

Y1 - 2018/4/24

N2 - We present a novel method to easily and reliably transfer highly porous, large area, thin microfabricated Polydimethylsiloxane (PDMS) porous membranes on Lab-on-Chip (LOC) and Organ-on-Chip (OOC) devices. The use of silicon as carrier substrate and a water-soluble sacrificial layer allows a simple and reproducible transfer of the membranes to any PDMS-based OOC and LOC device. The use of IC and MEMS compatible techniques reduces significantly the fabrication time and the need of manual handling. Our method is suitable for automatic assembling systems, such as pick-and-place, crucial to significantly increase the throughput of OOC and LOC devices assembling. Membranes with 8 μm pore size and as thin as 4 μm are successfully transferred. The viability and biocompatibility of the transfer was assessed by culturing two different cell lines on an OOC with transferred porous PDMS membranes.

AB - We present a novel method to easily and reliably transfer highly porous, large area, thin microfabricated Polydimethylsiloxane (PDMS) porous membranes on Lab-on-Chip (LOC) and Organ-on-Chip (OOC) devices. The use of silicon as carrier substrate and a water-soluble sacrificial layer allows a simple and reproducible transfer of the membranes to any PDMS-based OOC and LOC device. The use of IC and MEMS compatible techniques reduces significantly the fabrication time and the need of manual handling. Our method is suitable for automatic assembling systems, such as pick-and-place, crucial to significantly increase the throughput of OOC and LOC devices assembling. Membranes with 8 μm pore size and as thin as 4 μm are successfully transferred. The viability and biocompatibility of the transfer was assessed by culturing two different cell lines on an OOC with transferred porous PDMS membranes.

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U2 - 10.1109/MEMSYS.2018.8346550

DO - 10.1109/MEMSYS.2018.8346550

M3 - Conference contribution

SN - 9781538647820

VL - 2018-January

T3 - Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)

SP - 318

EP - 321

BT - 2018 IEEE Micro Electro Mechanical Systems, MEMS 2018

PB - IEEE

ER -

Quiros-Solano WF, Gaio N, Silvestri C, Arik YB, Stassen OMJA, Van Der Meer AD et al. A novel method to transfer porous PDMS membranes for high throughput Organ-on-Chip and Lab-on-Chip assembly. In 2018 IEEE Micro Electro Mechanical Systems, MEMS 2018. Vol. 2018-January. IEEE. 2018. p. 318-321. (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)). https://doi.org/10.1109/MEMSYS.2018.8346550