A Novel Plasma-Based Fluid for Particle Image Velocimetry (PIV): In-Vitro Feasibility Study of Flow Diverter Effects in Aneurysm Model

Johanna Clauser, Marius S. Knieps, Martin Büsen, Andreas Ding, Thomas Schmitz-Rode, Ulrich Steinseifer, Jutta Arens, Giorgio Cattaneo*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Abstract

Particle image velocimetry (PIV) is a commonly used method for in vitro investigation of fluid dynamics in biomedical devices, such as flow diverters for intracranial aneurysm treatment. Since it is limited to transparent blood substituting fluids like water-glycerol mixture, the influence of coagulation and platelet aggregation is neglected. We aimed at the development and the application of a modified platelet rich plasma as a new PIV fluid with blood-like rheological and coagulation properties. In standardized intracranial aneurysm silicone models, the effect of this new PIV plasma on the fluid dynamics before and after flow diverter implantation was evaluated and compared with water-glycerol measurements. The flow diverting effect was strongly dependent on the used fluid, with considerably lower velocities achieved using PIV plasma, despite the same starting viscosity of both fluids. Moreover, triggering coagulation of PIV plasma allowed for intra-aneurysmal clot formation. We presented the first in vitro PIV investigation using a non-Newtonian, clottable PIV plasma, demonstrating a mismatch to a standard PIV fluid and allowing for thrombus formation.

Original languageEnglish
Pages (from-to)841-848
Number of pages8
JournalAnnals of biomedical engineering
Volume46
Issue number6
DOIs
Publication statusPublished - 1 Jun 2018
Externally publishedYes

Keywords

  • Blood rheology
  • Flow diverter
  • Intracranial aneurysm
  • Particle image velocimetry (PIV)
  • Platelet rich plasma (PRP)

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