A poly(D,L-lactide) resin for the preparation of tissue engineering scaffolds by stereolithography

F.P.W. Melchels, Jan Feijen, Dirk W. Grijpma

Research output: Contribution to journalArticleAcademicpeer-review

263 Citations (Scopus)

Abstract

Porous polylactide constructs were prepared by stereolithography, for the first time without the use of reactive diluents. Star-shaped poly(d,l-lactide) oligomers with 2, 3 and 6 arms were synthesised, end-functionalised with methacryloyl chloride and photo-crosslinked in the presence of ethyl lactate as a non-reactive diluent. The molecular weights of the arms of the macromers were 0.2, 0.6, 1.1 and 5 kg/mol, allowing variation of the crosslink density of the resulting networks. Networks prepared from macromers of which the molecular weight per arm was 0.6 kg/mol or higher had good mechanical properties, similar to linear high-molecular weight poly(d,l-lactide). A resin based on a 2-armed poly(d,l-lactide) macromer with a molecular weight of 0.6 kg/mol per arm (75 wt%), ethyl lactate (19 wt%), photo-initiator (6 wt%), inhibitor and dye was prepared. Using this resin, films and computer-designed porous constructs were accurately fabricated by stereolithography. Pre-osteoblasts showed good adherence to these photo-crosslinked networks. The proliferation rate on these materials was comparable to that on high-molecular weight poly(d,l-lactide) and tissue culture polystyrene
Original languageEnglish
Pages (from-to)3801-3809
JournalBiomaterials
Volume30
Issue number23-24
DOIs
Publication statusPublished - 2009

Keywords

  • METIS-263350
  • EC Grant Agreement nr.: FP6/500465
  • IR-76381

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