A prefilled, ready-to-use electrophoresis based lab-on-a-chip device for monitoring lithium in blood

Arjan Floris, Steven Staal, Stefan Lenk, Erik Staijen, Dietrich Kohlheyer, Jan Eijkel, Albert van den Berg

    Research output: Contribution to journalArticleAcademicpeer-review

    73 Citations (Scopus)
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    Abstract

    We present the Medimate Multireader R, the first point-of-care lab on a chip device that is based on capillary electrophoresis. It employs disposable pre-filled microfluidic chips with closed electrode reservoirs and a single sample opening. Several technological innovations allow operation with closed reservoirs, which is essential for reliable point-of-care operation. The chips are inserted into a hand-held analyzer. In the present application, the device is used to measure the lithium concentration in blood. Lithium is quantified by conductivity detection after separation from other blood ions. Measurements in patients show good accuracy and precision, and there is no difference between the results obtained by skilled and non-skilled operators. This point-of-care device shows great promise as a platform for the determination of ionic substances in diagnostics or environmental analysis
    Original languageEnglish
    Pages (from-to)1799-1806
    Number of pages8
    JournalLab on a chip
    Volume10
    Issue number14
    DOIs
    Publication statusPublished - 2010

    Keywords

    • 22/4 OA procedure

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