A pressure driven injection system for an ultra flat chromatograpic microchannel

Emil Chmela; Marko T. Blom; (Han) J.G.E. Gardeniers; Albert van den Berg; Robert Tijssen

doi:10.1039/b206932f

A pressure driven injection system for an ultra flat chromatograpic microchannel

Emil Chmela, Marko T. Blom, (Han) J.G.E. Gardeniers, Albert van den Berg, Robert Tijssen

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Abstract

A pressure-actuated on-chip injection system has been developed that is compatible with shallow microchannels with a very large aspect ratio, i.e. 1 mm deep and up to 1000 mm wide. Such channels offer potential advantages in the miniaturisation of liquid chromatography and other separation methods as they allow high loadability and low sample dispersion at the same time. Computational fluid dynamics simulations were performed to predict the flow profiles and the transport of a sample in the system and to justify the injection principle. Based on these simulations, a prototype integrated into a chip for hydrodynamic chromatography has been realised and tested experimentally. The performance of the device is satisfactory and the results are in qualitative agreement with the numerical models.

Original language	English
Pages (from-to)	235-241
Journal	Lab on a chip
Volume	2
Issue number	4
DOIs	https://doi.org/10.1039/b206932f
Publication status	Published - 2002

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abstract = "A pressure-actuated on-chip injection system has been developed that is compatible with shallow microchannels with a very large aspect ratio, i.e. 1 mm deep and up to 1000 mm wide. Such channels offer potential advantages in the miniaturisation of liquid chromatography and other separation methods as they allow high loadability and low sample dispersion at the same time. Computational fluid dynamics simulations were performed to predict the flow profiles and the transport of a sample in the system and to justify the injection principle. Based on these simulations, a prototype integrated into a chip for hydrodynamic chromatography has been realised and tested experimentally. The performance of the device is satisfactory and the results are in qualitative agreement with the numerical models.",

author = "Emil Chmela and Blom, {Marko T.} and Gardeniers, {(Han) J.G.E.} and {van den Berg}, Albert and Robert Tijssen",

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AU - van den Berg, Albert

AU - Tijssen, Robert

PY - 2002

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AB - A pressure-actuated on-chip injection system has been developed that is compatible with shallow microchannels with a very large aspect ratio, i.e. 1 mm deep and up to 1000 mm wide. Such channels offer potential advantages in the miniaturisation of liquid chromatography and other separation methods as they allow high loadability and low sample dispersion at the same time. Computational fluid dynamics simulations were performed to predict the flow profiles and the transport of a sample in the system and to justify the injection principle. Based on these simulations, a prototype integrated into a chip for hydrodynamic chromatography has been realised and tested experimentally. The performance of the device is satisfactory and the results are in qualitative agreement with the numerical models.

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A pressure driven injection system for an ultra flat chromatograpic microchannel

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