A semi-anthropomorphic breast phantom with tunable blood oxygenation levels for use in quantitative photoacoustics

Maura Dantuma*, Javier Ortega Julia, Srirang Manohar

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Abstract

Photoacoustic imaging is an upcoming technique with potential in breast cancer screening and diagnosis. It is able to visualize the breast's vasculature. Its quantitative counterpart, called quantitative photoacoustics, potentially enables the derivation of local blood oxygen saturations when two or more optical wavelengths are used. Tumors can potentially be detected by looking at abnormal vessel shapes, high vascular densities or regions with a low oxygenation. In order to obtain accurate oxygen saturation estimations with quantitative photoacoustics, realistic light propagation models are required. Several models are available, but it is difficult to check their validity on real breasts due to the unknown ground truths, while simple objects having known ground truths are known to overestimate the performance of the algorithms. Therefore, measurements on an object that mimics the breast both optically as well as acoustically, and which has a complex but known morphology, are therefore required. We have previously reported on the first semi-anthropomorphic photoacoustic-ultrasound breast phantom. In this work, we build further upon this to make it suitable for use in quantitative photoacoustics. We demonstrate a method to embed blood vessels and tumors into the phantom where blood with a controlled oxygenation level can be flushed through.

Original languageEnglish
Title of host publicationTENCON 2019 - 2019 IEEE Region 10 Conference (TENCON)
Place of PublicationPiscataway, NJ
PublisherIEEE
Pages114-117
Number of pages4
ISBN (Electronic)978-1-7281-1895-6
ISBN (Print)978-1-7281-1896-3
DOIs
Publication statusPublished - 12 Dec 2019
EventIEEE Region 10 Conference: Technology, Knowledge, and Society, TENCON 2019 - Kochi, India
Duration: 17 Oct 201920 Oct 2019

Publication series

NameIEEE Region 10 Conference (TENCON)
PublisherIEEE
Volume2019
ISSN (Print)2159-3442
ISSN (Electronic)2159-3450

Conference

ConferenceIEEE Region 10 Conference: Technology, Knowledge, and Society, TENCON 2019
Abbreviated titleTENCON 2019
CountryIndia
CityKochi
Period17/10/1920/10/19

Keywords

  • Breast imaging
  • Photoacoustic
  • Quantitative photoacoustics

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    Dantuma, M., Ortega Julia, J., & Manohar, S. (2019). A semi-anthropomorphic breast phantom with tunable blood oxygenation levels for use in quantitative photoacoustics. In TENCON 2019 - 2019 IEEE Region 10 Conference (TENCON) (pp. 114-117). [8929428] (IEEE Region 10 Conference (TENCON); Vol. 2019). Piscataway, NJ: IEEE. https://doi.org/10.1109/TENCON.2019.8929428