Abstract
We present a simple and robust microfabrication technique to create three-dimensional (3D) tapered polydimethylsiloxane (PDMS) channels. Tapered photoresist structures were fabricated by single-step lithography and thermal reflowing process, and the topography of the structures was controlled by varying design parameters, e.g., channel widths and length. Two half funnel-shaped PDMS replicas were combined to realize a 3D funnelshaped PDMS structure. Human umbilical vein endothelial cells (HUVECs) were cultured in the 3D funnel channel to form an artificial vessel network. We believe that the 3D topographic structures with controlled curvatures would be useful in many scientific and engineering fields, including lab-on-a-chip devices and bioinspired platforms.
| Original language | English |
|---|---|
| Title of host publication | 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences |
| Pages | 1156-1157 |
| Number of pages | 2 |
| ISBN (Electronic) | 978-1-7334190-0-0 |
| Publication status | Published - 27 Oct 2019 |
| Event | 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2019 - Congress Center Basel, Basel, Switzerland Duration: 27 Oct 2019 → 31 Oct 2019 Conference number: 23 https://cbmsociety.org/microtas/microtas2019/ |
Conference
| Conference | 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2019 |
|---|---|
| Abbreviated title | MicroTAS 2019 |
| Country/Territory | Switzerland |
| City | Basel |
| Period | 27/10/19 → 31/10/19 |
| Internet address |