A simple and robust fabrication method for creating 3D tapered polydimethylsiloxane channels

Hoon Suk Rho, Henk-Willem Veltkamp, Danielle Baptista, Severine le Gac, Pamela Habibovic

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    Abstract

    We present a simple and robust microfabrication technique to create three-dimensional (3D) tapered polydimethylsiloxane (PDMS) channels. Tapered photoresist structures were fabricated by single-step lithography and thermal reflowing process, and the topography of the structures was controlled by varying design parameters, e.g., channel widths and length. Two half funnel-shaped PDMS replicas were combined to realize a 3D funnelshaped PDMS structure. Human umbilical vein endothelial cells (HUVECs) were cultured in the 3D funnel channel to form an artificial vessel network. We believe that the 3D topographic structures with controlled curvatures would be useful in many scientific and engineering fields, including lab-on-a-chip devices and bioinspired platforms.
    Original languageEnglish
    Title of host publication23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences
    Pages1156-1157
    Number of pages2
    ISBN (Electronic)978-1-7334190-0-0
    Publication statusPublished - 27 Oct 2019
    Event23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2019 - Congress Center Basel, Basel, Switzerland
    Duration: 27 Oct 201931 Oct 2019
    Conference number: 23
    https://cbmsociety.org/microtas/microtas2019/

    Conference

    Conference23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2019
    Abbreviated titleMicroTAS 2019
    CountrySwitzerland
    CityBasel
    Period27/10/1931/10/19
    Internet address

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  • Cite this

    Rho, H. S., Veltkamp, H-W., Baptista, D., le Gac, S., & Habibovic, P. (2019). A simple and robust fabrication method for creating 3D tapered polydimethylsiloxane channels. In 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 1156-1157)