A simple approach to sensor discovery and fabrication on self-assembled monolayers on glass

M.L. Basabe Desmonts, J. Beld, R.S. Zimmerman, J. Hernando Campos, P. Mela, M.F. Garcia Parajo, N.F. van Hulst, Albert van den Berg, David Reinhoudt, Mercedes Crego Calama

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Self-assembled monolayers (SAMs) on glass were used as a platform to sequentially deposit fluorophores and small molecules for ion sensing. The preorganization provided by the surface avoids the need for complex receptor design, allowing for a combinatorial approach to sensing systems based on small molecules. The resulting libraries are easily measured and show varied responses to a series of both cations and anions. This technology is transferable from the macro- to the microscale both via microcontact printing (CP), where the fluorophore is printed onto a glass surface, and via direct attachment of the fluorophore to microchannel walls. The ease of miniaturization of this technology may make the generation of a wide variety of simple yet efficient microarrays possible.
Original languageUndefined
Pages (from-to)7293-7299
Number of pages7
JournalJournal of the American Chemical Society
Issue number23
Publication statusPublished - 2004


  • IR-49548
  • METIS-222145

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