A Study of the Dynamics of Cardiac Ischemia using Experimental and Modeling Approaches

Shibaji Shome, J.G. Stinstra, Bruce Hopenfeld, Bonnie B. Punske, Rob S. Macleod

Research output: Contribution to conferencePaperAcademic

6 Citations (Scopus)
100 Downloads (Pure)

Abstract

The dynamics of cardiac ischemia was investigated using experimental studies and computer simulations. An experimental model consisting of an isolated and perfused canine heart with full control over blood flow rate to a targeted coronary artery was used in the experimental study and a realistically shaped computer model of a canine heart, incorporating anisotropic conductivity and realistic fiber orientation, was used in the simulation study. The phenomena investigated were: (1) the influence of fiber rotation on the epicardial potentials during ischemia and (2) the effect of conductivity changes during a period of sustained ischemia. Comparison of preliminary experimental and computer simulation results suggest that as the ischemic region grows from the endocardium towards the epicardium, the epicardial potential patterns follow the rotating fiber orientation in the myocardium. Secondly, in the experimental studies it was observed that prolonged ischemia caused a subsequent reduction in the magnitude of epicardial potentials. Similar results were obtained from the computer model when the conductivity of the tissue in the ischemic region was reduced
Original languageUndefined
Pages3585-3588
Publication statusPublished - 2004
Event26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, IEMBS 2004 - San Francisco, United States
Duration: 1 Sep 20045 Sep 2004
Conference number: 26

Conference

Conference26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, IEMBS 2004
Abbreviated titleIEMBS
CountryUnited States
CitySan Francisco
Period1/09/045/09/04

Keywords

  • IR-59751

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