A study on the grafting reaction of isocyanates with hydroxyapatite particles

Q. Liu, J.R. de Wijn, C.A. van Blitterswijk

Research output: Contribution to journalArticleAcademic

90 Citations (Scopus)


The surface grafting reactions of a series of isocyanates with hydroxyapatite particles at different temperatures were studied by Infrared spectrophotometry (IR) and thermal gravimetric analysis (TGA). The study results show that both hexamethylene diisocyanate (HMDI) and isocyanatoethyl methacrylate (ICEM) react readily with HA while ethyl isocyanate acetate (EIA) and butyl isocyanate (BIC) have lower reactivity towards HA particles. It also has been found that the reaction of ICEM with HA follows a second-order reaction mechanism, despite the heterogeneous nature of the reaction, while the reaction of HMDI with HA does not due to the complexity of the reaction. Based on this study, it is concluded that ICEM and HMDI are suitable agents for the coupling of polymers due to their reactivity towards HA.
Original languageEnglish
Pages (from-to)358-364
JournalJournal of biomedical materials research
Issue number3
Publication statusPublished - 1998


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