A synovial membrane-on-chip studying the development of rheumatoid arthritis in a triple culture system

Carlo Alberto Paggi; Nuno Miguel Araújo da Cunha Gomes; Agnieszka Zuchowska; Marcel Karperien; Severine le Gac

A synovial membrane-on-chip studying the development of rheumatoid arthritis in a triple culture system

Carlo Alberto Paggi, Nuno Miguel Araújo da Cunha Gomes, Agnieszka Zuchowska, Marcel Karperien, Severine le Gac

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

Abstract

Rheumatoid arthritis is a common disease characterized by, amongst others, synovial inflammation. We successfully established a triple co-culture with human synovial fibroblasts, macrophages and endothelial cells to mimic the synovial membrane of articulating joints. We next demonstrated that macrophages were integrated in the fibroblast layer and that, provided biochemical stimulation, it was possible to trigger an immune response resembling rheumatoid arthritis (RA).

Original language	English
Title of host publication	MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences
Publisher	The Chemical and Biological Microsystems Society
Pages	485-486
Number of pages	2
ISBN (Electronic)	9781733419031
ISBN (Print)	978-1-7334190-3-1
Publication status	Published - 10 Oct 2021
Event	25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2021 - Palm Springs, United States Duration: 10 Oct 2021 → 14 Oct 2021 Conference number: 25 https://microtas2021.org/

Conference

Conference	25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2021
Abbreviated title	MicroTAS 2021
Country/Territory	United States
City	Palm Springs
Period	10/10/21 → 14/10/21
Internet address	https://microtas2021.org/

Keywords

disease model
extracellular matrix
immune system
inflammatory stimulation
synovial membrane

Cite this

Paggi, C. A., Araújo da Cunha Gomes, N. M., Zuchowska, A., Karperien, M., & le Gac, S. (2021). A synovial membrane-on-chip studying the development of rheumatoid arthritis in a triple culture system. In MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 485-486). The Chemical and Biological Microsystems Society.

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title = "A synovial membrane-on-chip studying the development of rheumatoid arthritis in a triple culture system",

abstract = "Rheumatoid arthritis is a common disease characterized by, amongst others, synovial inflammation. We successfully established a triple co-culture with human synovial fibroblasts, macrophages and endothelial cells to mimic the synovial membrane of articulating joints. We next demonstrated that macrophages were integrated in the fibroblast layer and that, provided biochemical stimulation, it was possible to trigger an immune response resembling rheumatoid arthritis (RA).",

keywords = "disease model, extracellular matrix, immune system, inflammatory stimulation, synovial membrane",

author = "Paggi, {Carlo Alberto} and {Ara{\'u}jo da Cunha Gomes}, {Nuno Miguel} and Agnieszka Zuchowska and Marcel Karperien and {le Gac}, Severine",

note = "Publisher Copyright: {\textcopyright} 2021 MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences. All rights reserved.; 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2021, MicroTAS 2021 ; Conference date: 10-10-2021 Through 14-10-2021",

year = "2021",

month = oct,

day = "10",

language = "English",

isbn = "978-1-7334190-3-1",

pages = "485--486",

booktitle = "MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences",

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Paggi, CA , Araújo da Cunha Gomes, NM, Zuchowska, A, Karperien, M & le Gac, S 2021, A synovial membrane-on-chip studying the development of rheumatoid arthritis in a triple culture system. in MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences. The Chemical and Biological Microsystems Society, pp. 485-486, 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2021, Palm Springs, California, United States, 10/10/21.

A synovial membrane-on-chip studying the development of rheumatoid arthritis in a triple culture system. / Paggi, Carlo Alberto ; Araújo da Cunha Gomes, Nuno Miguel; Zuchowska, Agnieszka et al.
MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences. The Chemical and Biological Microsystems Society, 2021. p. 485-486.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

TY - GEN

T1 - A synovial membrane-on-chip studying the development of rheumatoid arthritis in a triple culture system

AU - Paggi, Carlo Alberto

AU - Araújo da Cunha Gomes, Nuno Miguel

AU - Zuchowska, Agnieszka

AU - Karperien, Marcel

AU - le Gac, Severine

N1 - Conference code: 25

PY - 2021/10/10

Y1 - 2021/10/10

N2 - Rheumatoid arthritis is a common disease characterized by, amongst others, synovial inflammation. We successfully established a triple co-culture with human synovial fibroblasts, macrophages and endothelial cells to mimic the synovial membrane of articulating joints. We next demonstrated that macrophages were integrated in the fibroblast layer and that, provided biochemical stimulation, it was possible to trigger an immune response resembling rheumatoid arthritis (RA).

AB - Rheumatoid arthritis is a common disease characterized by, amongst others, synovial inflammation. We successfully established a triple co-culture with human synovial fibroblasts, macrophages and endothelial cells to mimic the synovial membrane of articulating joints. We next demonstrated that macrophages were integrated in the fibroblast layer and that, provided biochemical stimulation, it was possible to trigger an immune response resembling rheumatoid arthritis (RA).

KW - disease model

KW - extracellular matrix

KW - immune system

KW - inflammatory stimulation

KW - synovial membrane

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M3 - Conference contribution

AN - SCOPUS:85136954573

SN - 978-1-7334190-3-1

SP - 485

EP - 486

BT - MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences

PB - The Chemical and Biological Microsystems Society

T2 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2021

Y2 - 10 October 2021 through 14 October 2021

ER -

A synovial membrane-on-chip studying the development of rheumatoid arthritis in a triple culture system

Abstract

Conference

Keywords

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A synovial membrane-on-chip studying the development of rheumatoid arthritis in a triple culture system

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