A system for fluid dosing in the nanoliter range

Sebastian Böhm, Dorota Pijanowska, Wouter Olthuis, Piet Bergveld

    Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review


    A system for the dosing of nanoliter amounts of fluids is presented. It is based on the displacement of fluid from a reservoir by the electrochemical production of gas bubbles at noble metal electrodes. The total volume of fluid that is dispensed can be controlled by the current that is sent through the electrodes. This simple principle was applied to calibrate a pH ISFET mounted in a flow through system by dispensing two different pH buffers in the carrier stream leading to the ISFET. The offset and sensitivity resulting from the two point calibration was in close agreement with the manual calibration procedure carried out before. First experiments were performed using a system machined in plastic using conventional techniques but it is shown that by adopting appropriate micromachining techniques a structure results that can easily be integrated in a microsystem for (bio)chemical analyses.
    Original languageEnglish
    Title of host publicationSensor technology in the Netherlands - state of the art
    Subtitle of host publicationproceedings of the Dutch Sensor Conference, 2-3 March, 1998, University of Twente, the Netherlands
    EditorsA. van den Berg, P. Bergveld
    Place of PublicationDordrecht
    PublisherKluwer Academic Publishers
    Number of pages5
    ISBN (Electronic)978-94-011-5010-1
    ISBN (Print)978-94-010-6103-2
    Publication statusPublished - 2 Mar 1998
    EventDutch Sensor Conference 1998: Sensor Technology in the Netherlands: State of the Art - University of Twente, Enschede, Netherlands
    Duration: 2 Mar 19983 Mar 1998

    Publication series

    NameMESA monographs
    PublisherKluwer Academic Publishers


    ConferenceDutch Sensor Conference 1998


    • Electrochemical pump
    • Liquid dosing

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