A series of neutral water soluble calixarenes was synthesized via direct chlorosulfonylation followed by reaction with hydroxyl group-containing amines. The solubility of these calixarene sulfonamides in water, as determined by means of UV measurements, varies from ~ 10−5 to 0.31 M.
Grote gansey, M. H. B., Grote Gansey, M. H. B., Verboom, W., & Reinhoudt, D. (1994). A systematic study to neutral, water soluble calixarenes. Tetrahedron letters, 35(35), 7127-7130. https://doi.org/10.1016/0040-4039(94)88243-6