A trypsin-based bistable switch

Sjoerd G.J. Postma; Dana te Brinke; Ilia N. Vialshin; Albert S.Y. Wong; Wilhelm T.S. Huck

doi:10.1016/j.tet.2017.04.053

A trypsin-based bistable switch

Sjoerd G.J. Postma, Dana te Brinke, Ilia N. Vialshin, Albert S.Y. Wong, Wilhelm T.S. Huck^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

17 Citations (Scopus)

3 Downloads (Pure)

Abstract

Recreating some of the emergent behavior seen in biological reaction networks is an important goal in the new field of systems chemistry. One of the classic examples of complex behavior is bistability, which is abundantly used in living organisms for switching between cellular states. Here, we create a bistable switch based on the autocatalytic activation and inhibition of the enzyme trypsin under flow conditions. We investigate the influence of the inhibitor structure, and hence inhibition kinetics, on the properties of the bistable switch.

Original language	English
Pages (from-to)	4896-4900
Number of pages	5
Journal	Tetrahedron
Volume	73
Issue number	33
DOIs	https://doi.org/10.1016/j.tet.2017.04.053
Publication status	Published - 2017
Externally published	Yes

Keywords

Bistability
Complex behavior
Enzymes
Reaction networks

Access to Document

10.1016/j.tet.2017.04.053Licence: CC BY-NC-ND

1-s2.0-S0040402017304453-mainFinal published version, 663 KBLicence: CC BY-NC-ND

Cite this

@article{e9f9bf746c1d46ee8ee027566e7ee5d8,

title = "A trypsin-based bistable switch",

abstract = "Recreating some of the emergent behavior seen in biological reaction networks is an important goal in the new field of systems chemistry. One of the classic examples of complex behavior is bistability, which is abundantly used in living organisms for switching between cellular states. Here, we create a bistable switch based on the autocatalytic activation and inhibition of the enzyme trypsin under flow conditions. We investigate the influence of the inhibitor structure, and hence inhibition kinetics, on the properties of the bistable switch.",

keywords = "Bistability, Complex behavior, Enzymes, Reaction networks",

author = "Postma, {Sjoerd G.J.} and {te Brinke}, Dana and Vialshin, {Ilia N.} and Wong, {Albert S.Y.} and Huck, {Wilhelm T.S.}",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier Ltd",

year = "2017",

doi = "10.1016/j.tet.2017.04.053",

language = "English",

volume = "73",

pages = "4896--4900",

journal = "Tetrahedron",

issn = "0040-4020",

publisher = "Elsevier Ltd",

number = "33",

}

TY - JOUR

T1 - A trypsin-based bistable switch

AU - Postma, Sjoerd G.J.

AU - te Brinke, Dana

AU - Vialshin, Ilia N.

AU - Wong, Albert S.Y.

AU - Huck, Wilhelm T.S.

PY - 2017

Y1 - 2017

N2 - Recreating some of the emergent behavior seen in biological reaction networks is an important goal in the new field of systems chemistry. One of the classic examples of complex behavior is bistability, which is abundantly used in living organisms for switching between cellular states. Here, we create a bistable switch based on the autocatalytic activation and inhibition of the enzyme trypsin under flow conditions. We investigate the influence of the inhibitor structure, and hence inhibition kinetics, on the properties of the bistable switch.

AB - Recreating some of the emergent behavior seen in biological reaction networks is an important goal in the new field of systems chemistry. One of the classic examples of complex behavior is bistability, which is abundantly used in living organisms for switching between cellular states. Here, we create a bistable switch based on the autocatalytic activation and inhibition of the enzyme trypsin under flow conditions. We investigate the influence of the inhibitor structure, and hence inhibition kinetics, on the properties of the bistable switch.

KW - Bistability

KW - Complex behavior

KW - Enzymes

KW - Reaction networks

UR - http://www.scopus.com/inward/record.url?scp=85018375290&partnerID=8YFLogxK

U2 - 10.1016/j.tet.2017.04.053

DO - 10.1016/j.tet.2017.04.053

M3 - Article

AN - SCOPUS:85018375290

SN - 0040-4020

VL - 73

SP - 4896

EP - 4900

JO - Tetrahedron

JF - Tetrahedron

IS - 33

ER -

A trypsin-based bistable switch

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this