Abnormal distribution of CD8 subpopulation in B-chronic lymphocytic leukemia identified by flow cytometry

Leonardus Wendelinus Mathias Marie Terstappen, B.G. de Grooth, W. van Berkel, C.H.H. ten Napel

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We studied the occurrence of T-cell subpopulations for patients with B-cell chronic lymphocytic leukemia. The CD8+ population was divided into CD8+ suppressor (CD8a+) and CD8+ cytotoxic (CD8b+) lymphocytes using difference in orthogonal light scattering. Average CD4+/CD8+ratios determined for all patients were decreased. For individual patients this sometimes was not true. In contrast CD4+/CD8a+ ratios were markedly increased in all individual patients. The CD8+ lymphocytes appeared to consist mainly of CD8b+lymphocytes. Moreover the CD8b+/CD8+ ratio correlated with clinical stage: untreated patients (stage 0 of Rai) have smaller CD8b+/CD8+ ratios than patients with advanced stages of Rai.
Original languageUndefined
Pages (from-to)551-557
JournalLeukemia Research
Issue number7
Publication statusPublished - 1988


  • IR-70288

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