ABO incompatibility and RhIG immunoprophylaxis protect against non-D alloimmunization by pregnancy

Carolien Zwiers, Joke M. Koelewijn, Lisa Vermij, Joost van Sambeeck, Dick Oepkes, Masja de Haas, C. Ellen van der Schoot*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Abstract

Hemolytic disease of the fetus and newborn (HDFN) is a serious pregnancy complication, caused by maternal antibodies against fetal red blood cell (RBC) antigens. These antibodies may provoke fetal hemolysis, resulting in fetal anemia, hydrops, and even death if left untreated.1,2 HDFN is most frequently caused by antibodies with anti-D specificity, followed by anti-K, anti-c, anti-E, other Rh antibodies, or exceptionally, anti-Fy (Duffy) or anti-Jk (Kidd).
Original languageEnglish
Pages (from-to)1611-1617
JournalTransfusion
Volume58
Issue number7
Early online date6 Apr 2018
DOIs
Publication statusPublished - 1 Jul 2018

Keywords

  • UT-Hybrid-D
  • Immunoprophylaxis
  • ABO incompatibility
  • Hemolytic disease of the fetus and newborn

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    Zwiers, C., Koelewijn, J. M., Vermij, L., van Sambeeck, J., Oepkes, D., de Haas, M., & van der Schoot, C. E. (2018). ABO incompatibility and RhIG immunoprophylaxis protect against non-D alloimmunization by pregnancy. Transfusion, 58(7), 1611-1617. https://doi.org/10.1111/trf.14606