About Chemical Strategies to Fabricate Cell-Instructive Biointerfaces with Static and Dynamic Complexity

Gülistan Koçer, Pascal Jonkheijm

Research output: Contribution to journalReview articleAcademicpeer-review

10 Citations (Scopus)
4 Downloads (Pure)

Abstract

Properly functioning cell-instructive biointerfaces are critical for healthy integration of biomedical devices in the body and serve as decisive tools for the advancement of our understanding of fundamental cell biological phenomena. Studies are reviewed that use covalent chemistries to fabricate cell-instructive biointerfaces. These types of biointerfaces typically result in a static presentation of predefined cell-instructive cues. Chemically defined, but dynamic cell-instructive biointerfaces introduce spatiotemporal control over cell-instructive cues and present another type of biointerface, which promises a more biomimetic way to guide cell behavior. Therefore, strategies that offer control over the lateral sorting of ligands, the availability and molecular structure of bioactive ligands, and strategies that offer the ability to induce physical, chemical and mechanical changes in situ are reviewed. Specific attention is paid to state-of-the-art studies on dynamic, cell-instructive 3D materials. Future work is expected to further deepen our understanding of molecular and cellular biological processes investigating cell-type specific responses and the translational steps toward targeted in vivo applications.

Original languageEnglish
Article number1701192
JournalAdvanced healthcare materials
Volume7
Issue number14
DOIs
Publication statusPublished - 25 Jul 2018

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Ligands
Biomimetics
Sorting
Molecular structure
Availability
Biological Phenomena
Cues
Aptitude
Molecular Structure
Equipment and Supplies

Keywords

  • UT-Hybrid-D
  • biomaterials
  • biomimetics
  • cell–surface interactions
  • dynamics
  • extracellular matrix
  • self-assembly
  • biointerfaces

Cite this

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title = "About Chemical Strategies to Fabricate Cell-Instructive Biointerfaces with Static and Dynamic Complexity",
abstract = "Properly functioning cell-instructive biointerfaces are critical for healthy integration of biomedical devices in the body and serve as decisive tools for the advancement of our understanding of fundamental cell biological phenomena. Studies are reviewed that use covalent chemistries to fabricate cell-instructive biointerfaces. These types of biointerfaces typically result in a static presentation of predefined cell-instructive cues. Chemically defined, but dynamic cell-instructive biointerfaces introduce spatiotemporal control over cell-instructive cues and present another type of biointerface, which promises a more biomimetic way to guide cell behavior. Therefore, strategies that offer control over the lateral sorting of ligands, the availability and molecular structure of bioactive ligands, and strategies that offer the ability to induce physical, chemical and mechanical changes in situ are reviewed. Specific attention is paid to state-of-the-art studies on dynamic, cell-instructive 3D materials. Future work is expected to further deepen our understanding of molecular and cellular biological processes investigating cell-type specific responses and the translational steps toward targeted in vivo applications.",
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About Chemical Strategies to Fabricate Cell-Instructive Biointerfaces with Static and Dynamic Complexity. / Koçer, Gülistan; Jonkheijm, Pascal.

In: Advanced healthcare materials, Vol. 7, No. 14, 1701192, 25.07.2018.

Research output: Contribution to journalReview articleAcademicpeer-review

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AB - Properly functioning cell-instructive biointerfaces are critical for healthy integration of biomedical devices in the body and serve as decisive tools for the advancement of our understanding of fundamental cell biological phenomena. Studies are reviewed that use covalent chemistries to fabricate cell-instructive biointerfaces. These types of biointerfaces typically result in a static presentation of predefined cell-instructive cues. Chemically defined, but dynamic cell-instructive biointerfaces introduce spatiotemporal control over cell-instructive cues and present another type of biointerface, which promises a more biomimetic way to guide cell behavior. Therefore, strategies that offer control over the lateral sorting of ligands, the availability and molecular structure of bioactive ligands, and strategies that offer the ability to induce physical, chemical and mechanical changes in situ are reviewed. Specific attention is paid to state-of-the-art studies on dynamic, cell-instructive 3D materials. Future work is expected to further deepen our understanding of molecular and cellular biological processes investigating cell-type specific responses and the translational steps toward targeted in vivo applications.

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