Absence of enhanced uptake of fluorescent magnetic particles into human liver cells in a strong magnetic field gradient

Leon Abelmann; Eunheui Gwag; Baeckkyoung Sung

doi:10.48550/arXiv.2101.03006

Absence of enhanced uptake of fluorescent magnetic particles into human liver cells in a strong magnetic field gradient

Leon Abelmann, Eunheui Gwag, Baeckkyoung Sung

Robotics and Mechatronics

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Abstract

We investigated whether we can detect enhanced magnetic nanoparticle uptake under application of a large magnetic force by tagging the particles with a fluorescent dye. Human liver cells were cultured in a micro-channel slide and exposed to two types of magnetic nanoparticles with a diameter of 100 nm at a concentration of 10000 particles/cell for 24 hours. Even though we achieved a magnetic force that exceeded the gravitational force by a factor of 25, we did not observe a statistically significant increase of immobilised particles per cell.

Original language	English
Publisher	ArXiv.org
DOIs	https://doi.org/10.48550/arXiv.2101.03006
Publication status	Published - 8 Jan 2021

Keywords

physics.bio-ph

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10.48550/arXiv.2101.03006

2101.03006v1Final published version, 41.1 MBLicence: CC BY

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Absence of enhanced uptake of fluorescent magnetic particles into human liver cells in a strong magnetic field gradient

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