Accelerated 4D phase contrast MRI in skeletal muscle contraction

Valentina Mazzoli (Corresponding Author), Lukas M. Gottwald, Eva S. Peper, Martijn Froeling, Bram F. Coolen, Nico Verdonschot, Andre M. Sprengers, Pim van Ooij, Gustav J. Strijkers, Aart J. Nederveen

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)
24 Downloads (Pure)

Abstract

Purpose: 3D time-resolved (4D) phase contrast MRI can be used to study muscle contraction. However, 3D coverage with sufficient spatiotemporal resolution can only be achieved by interleaved acquisitions during many repetitions of the motion task, resulting in long scan times. The aim of this study was to develop a compressed sensing accelerated 4D phase contrast MRI technique for quantification of velocities and strain rate of the muscles in the lower leg during active plantarflexion/dorsiflexion.
Methods: Nine healthy volunteers were scanned during active dorsiflexion/plantarflexion task. For each volunteer, we acquired a reference scan, as well as 4 different accelerated scans (k-space undersampling factors: 3.14X, 4.09X, 4.89X, and 6.41X) obtained using Cartesian Poisson disk undersampling schemes. The data was reconstructed using a compressed sensing pipeline. For each scan, velocity and strain rate values were quantified in the gastrocnemius lateralis, gastrocnemius medialis, tibialis anterior, and soleus.
Results: No significant differences in velocity values were observed as a function acceleration factor in the investigated muscles. The strain rate calculation resulted in one positive (s+) and one negative (s_) eigenvalue, whereas the third eigenvalue (s3) was consistently 0 for all the acquisitions. No significant differences were observed for the strain rate eigenvalues as a function of acceleration factor.
Conclusions: Data undersampling combined with compressed sensing reconstruction allowed obtainment of time-resolved phase contrast acquisitions with 3D coverage and quantitative information comparable to the reference scan. The 3D sensitivity of the method can help in understanding the connection between muscle architecture and muscle function in future studies.
Original languageEnglish
Pages (from-to)1799-1811
Number of pages13
JournalMagnetic resonance in medicine
Volume80
Issue number5
Early online date5 Mar 2018
DOIs
Publication statusPublished - 1 Nov 2018

Fingerprint

Muscle Contraction
Skeletal Muscle
Muscles
Volunteers
Leg
Healthy Volunteers

Keywords

  • UT-Hybrid-D
  • compressed sensing
  • muscle contraction
  • phase contrast
  • skeletal muscles
  • strain rate
  • MRI

Cite this

Mazzoli, V., Gottwald, L. M., Peper, E. S., Froeling, M., Coolen, B. F., Verdonschot, N., ... Nederveen, A. J. (2018). Accelerated 4D phase contrast MRI in skeletal muscle contraction. Magnetic resonance in medicine, 80(5), 1799-1811. https://doi.org/10.1002/mrm.27158
Mazzoli, Valentina ; Gottwald, Lukas M. ; Peper, Eva S. ; Froeling, Martijn ; Coolen, Bram F. ; Verdonschot, Nico ; Sprengers, Andre M. ; van Ooij, Pim ; Strijkers, Gustav J. ; Nederveen, Aart J. / Accelerated 4D phase contrast MRI in skeletal muscle contraction. In: Magnetic resonance in medicine. 2018 ; Vol. 80, No. 5. pp. 1799-1811.
@article{707374d4eabb42928afce23283022b06,
title = "Accelerated 4D phase contrast MRI in skeletal muscle contraction",
abstract = "Purpose: 3D time-resolved (4D) phase contrast MRI can be used to study muscle contraction. However, 3D coverage with sufficient spatiotemporal resolution can only be achieved by interleaved acquisitions during many repetitions of the motion task, resulting in long scan times. The aim of this study was to develop a compressed sensing accelerated 4D phase contrast MRI technique for quantification of velocities and strain rate of the muscles in the lower leg during active plantarflexion/dorsiflexion.Methods: Nine healthy volunteers were scanned during active dorsiflexion/plantarflexion task. For each volunteer, we acquired a reference scan, as well as 4 different accelerated scans (k-space undersampling factors: 3.14X, 4.09X, 4.89X, and 6.41X) obtained using Cartesian Poisson disk undersampling schemes. The data was reconstructed using a compressed sensing pipeline. For each scan, velocity and strain rate values were quantified in the gastrocnemius lateralis, gastrocnemius medialis, tibialis anterior, and soleus.Results: No significant differences in velocity values were observed as a function acceleration factor in the investigated muscles. The strain rate calculation resulted in one positive (s+) and one negative (s_) eigenvalue, whereas the third eigenvalue (s3) was consistently 0 for all the acquisitions. No significant differences were observed for the strain rate eigenvalues as a function of acceleration factor.Conclusions: Data undersampling combined with compressed sensing reconstruction allowed obtainment of time-resolved phase contrast acquisitions with 3D coverage and quantitative information comparable to the reference scan. The 3D sensitivity of the method can help in understanding the connection between muscle architecture and muscle function in future studies.",
keywords = "UT-Hybrid-D, compressed sensing, muscle contraction, phase contrast, skeletal muscles, strain rate, MRI",
author = "Valentina Mazzoli and Gottwald, {Lukas M.} and Peper, {Eva S.} and Martijn Froeling and Coolen, {Bram F.} and Nico Verdonschot and Sprengers, {Andre M.} and {van Ooij}, Pim and Strijkers, {Gustav J.} and Nederveen, {Aart J.}",
note = "Wiley deal",
year = "2018",
month = "11",
day = "1",
doi = "10.1002/mrm.27158",
language = "English",
volume = "80",
pages = "1799--1811",
journal = "Magnetic resonance in medicine",
issn = "0740-3194",
publisher = "Wiley",
number = "5",

}

Mazzoli, V, Gottwald, LM, Peper, ES, Froeling, M, Coolen, BF, Verdonschot, N, Sprengers, AM, van Ooij, P, Strijkers, GJ & Nederveen, AJ 2018, 'Accelerated 4D phase contrast MRI in skeletal muscle contraction' Magnetic resonance in medicine, vol. 80, no. 5, pp. 1799-1811. https://doi.org/10.1002/mrm.27158

Accelerated 4D phase contrast MRI in skeletal muscle contraction. / Mazzoli, Valentina (Corresponding Author); Gottwald, Lukas M.; Peper, Eva S.; Froeling, Martijn; Coolen, Bram F.; Verdonschot, Nico; Sprengers, Andre M.; van Ooij, Pim; Strijkers, Gustav J.; Nederveen, Aart J.

In: Magnetic resonance in medicine, Vol. 80, No. 5, 01.11.2018, p. 1799-1811.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Accelerated 4D phase contrast MRI in skeletal muscle contraction

AU - Mazzoli, Valentina

AU - Gottwald, Lukas M.

AU - Peper, Eva S.

AU - Froeling, Martijn

AU - Coolen, Bram F.

AU - Verdonschot, Nico

AU - Sprengers, Andre M.

AU - van Ooij, Pim

AU - Strijkers, Gustav J.

AU - Nederveen, Aart J.

N1 - Wiley deal

PY - 2018/11/1

Y1 - 2018/11/1

N2 - Purpose: 3D time-resolved (4D) phase contrast MRI can be used to study muscle contraction. However, 3D coverage with sufficient spatiotemporal resolution can only be achieved by interleaved acquisitions during many repetitions of the motion task, resulting in long scan times. The aim of this study was to develop a compressed sensing accelerated 4D phase contrast MRI technique for quantification of velocities and strain rate of the muscles in the lower leg during active plantarflexion/dorsiflexion.Methods: Nine healthy volunteers were scanned during active dorsiflexion/plantarflexion task. For each volunteer, we acquired a reference scan, as well as 4 different accelerated scans (k-space undersampling factors: 3.14X, 4.09X, 4.89X, and 6.41X) obtained using Cartesian Poisson disk undersampling schemes. The data was reconstructed using a compressed sensing pipeline. For each scan, velocity and strain rate values were quantified in the gastrocnemius lateralis, gastrocnemius medialis, tibialis anterior, and soleus.Results: No significant differences in velocity values were observed as a function acceleration factor in the investigated muscles. The strain rate calculation resulted in one positive (s+) and one negative (s_) eigenvalue, whereas the third eigenvalue (s3) was consistently 0 for all the acquisitions. No significant differences were observed for the strain rate eigenvalues as a function of acceleration factor.Conclusions: Data undersampling combined with compressed sensing reconstruction allowed obtainment of time-resolved phase contrast acquisitions with 3D coverage and quantitative information comparable to the reference scan. The 3D sensitivity of the method can help in understanding the connection between muscle architecture and muscle function in future studies.

AB - Purpose: 3D time-resolved (4D) phase contrast MRI can be used to study muscle contraction. However, 3D coverage with sufficient spatiotemporal resolution can only be achieved by interleaved acquisitions during many repetitions of the motion task, resulting in long scan times. The aim of this study was to develop a compressed sensing accelerated 4D phase contrast MRI technique for quantification of velocities and strain rate of the muscles in the lower leg during active plantarflexion/dorsiflexion.Methods: Nine healthy volunteers were scanned during active dorsiflexion/plantarflexion task. For each volunteer, we acquired a reference scan, as well as 4 different accelerated scans (k-space undersampling factors: 3.14X, 4.09X, 4.89X, and 6.41X) obtained using Cartesian Poisson disk undersampling schemes. The data was reconstructed using a compressed sensing pipeline. For each scan, velocity and strain rate values were quantified in the gastrocnemius lateralis, gastrocnemius medialis, tibialis anterior, and soleus.Results: No significant differences in velocity values were observed as a function acceleration factor in the investigated muscles. The strain rate calculation resulted in one positive (s+) and one negative (s_) eigenvalue, whereas the third eigenvalue (s3) was consistently 0 for all the acquisitions. No significant differences were observed for the strain rate eigenvalues as a function of acceleration factor.Conclusions: Data undersampling combined with compressed sensing reconstruction allowed obtainment of time-resolved phase contrast acquisitions with 3D coverage and quantitative information comparable to the reference scan. The 3D sensitivity of the method can help in understanding the connection between muscle architecture and muscle function in future studies.

KW - UT-Hybrid-D

KW - compressed sensing

KW - muscle contraction

KW - phase contrast

KW - skeletal muscles

KW - strain rate

KW - MRI

UR - http://www.scopus.com/inward/record.url?scp=85052092965&partnerID=8YFLogxK

U2 - 10.1002/mrm.27158

DO - 10.1002/mrm.27158

M3 - Article

VL - 80

SP - 1799

EP - 1811

JO - Magnetic resonance in medicine

JF - Magnetic resonance in medicine

SN - 0740-3194

IS - 5

ER -

Mazzoli V, Gottwald LM, Peper ES, Froeling M, Coolen BF, Verdonschot N et al. Accelerated 4D phase contrast MRI in skeletal muscle contraction. Magnetic resonance in medicine. 2018 Nov 1;80(5):1799-1811. https://doi.org/10.1002/mrm.27158