Accurate surgical navigation with real-time tumor tracking in cancer surgery

Esther N.D. Kok; Roeland Eppenga; Koert F.D. Kuhlmann; Harald C. Groen; Ruben van Veen; Jolanda M. van Dieren; Thomas R. de Wijkerslooth; Monique van Leerdam; Doenja M.J. Lambregts; Wouter J. Heerink; Nikie J. Hoetjes; Oleksandra Ivashchenko; Geerard L. Beets; Arend G.J. Aalbers; Jasper Nijkamp; Theo J.M. Ruers

doi:10.1038/s41698-020-0115-0

Accurate surgical navigation with real-time tumor tracking in cancer surgery

Esther N.D. Kok^*, Roeland Eppenga, Koert F.D. Kuhlmann, Harald C. Groen, Ruben van Veen, Jolanda M. van Dieren, Thomas R. de Wijkerslooth, Monique van Leerdam, Doenja M.J. Lambregts, Wouter J. Heerink, Nikie J. Hoetjes, Oleksandra Ivashchenko, Geerard L. Beets, Arend G.J. Aalbers, Jasper Nijkamp, Theo J.M. Ruers

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

In the past decades, image-guided surgery has evolved rapidly. In procedures with a relatively fixed target area, like neurosurgery and orthopedics, this has led to improved patient outcomes. In cancer surgery, intraoperative guidance could be of great benefit to secure radical resection margins since residual disease is associated with local recurrence and poor survival. However, most tumor lesions are mobile with a constantly changing position. Here, we present an innovative technique for real-time tumor tracking in cancer surgery. In this study, we evaluated the feasibility of real-time tumor tracking during rectal cancer surgery. The application of real-time tumor tracking using an intraoperative navigation system is feasible and safe with a high median target registration accuracy of 3 mm. This technique allows oncological surgeons to obtain real-time accurate information on tumor location, as well as critical anatomical information. This study demonstrates that real-time tumor tracking is feasible and could potentially decrease positive resection margins and improve patient outcome.

Original language	English
Article number	8
Journal	npj Precision Oncology
Volume	4
Issue number	1
DOIs	https://doi.org/10.1038/s41698-020-0115-0
Publication status	Published - 1 Dec 2020

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Kok, E. N. D., Eppenga, R., Kuhlmann, K. F. D., Groen, H. C., van Veen, R., van Dieren, J. M., de Wijkerslooth, T. R., van Leerdam, M., Lambregts, D. M. J., Heerink, W. J., Hoetjes, N. J., Ivashchenko, O., Beets, G. L., Aalbers, A. G. J., Nijkamp, J., & Ruers, T. J. M. (2020). Accurate surgical navigation with real-time tumor tracking in cancer surgery. npj Precision Oncology, 4(1), [8]. https://doi.org/10.1038/s41698-020-0115-0

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title = "Accurate surgical navigation with real-time tumor tracking in cancer surgery",

abstract = "In the past decades, image-guided surgery has evolved rapidly. In procedures with a relatively fixed target area, like neurosurgery and orthopedics, this has led to improved patient outcomes. In cancer surgery, intraoperative guidance could be of great benefit to secure radical resection margins since residual disease is associated with local recurrence and poor survival. However, most tumor lesions are mobile with a constantly changing position. Here, we present an innovative technique for real-time tumor tracking in cancer surgery. In this study, we evaluated the feasibility of real-time tumor tracking during rectal cancer surgery. The application of real-time tumor tracking using an intraoperative navigation system is feasible and safe with a high median target registration accuracy of 3 mm. This technique allows oncological surgeons to obtain real-time accurate information on tumor location, as well as critical anatomical information. This study demonstrates that real-time tumor tracking is feasible and could potentially decrease positive resection margins and improve patient outcome.",

author = "Kok, {Esther N.D.} and Roeland Eppenga and Kuhlmann, {Koert F.D.} and Groen, {Harald C.} and {van Veen}, Ruben and {van Dieren}, {Jolanda M.} and {de Wijkerslooth}, {Thomas R.} and {van Leerdam}, Monique and Lambregts, {Doenja M.J.} and Heerink, {Wouter J.} and Hoetjes, {Nikie J.} and Oleksandra Ivashchenko and Beets, {Geerard L.} and Aalbers, {Arend G.J.} and Jasper Nijkamp and Ruers, {Theo J.M.}",

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year = "2020",

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doi = "10.1038/s41698-020-0115-0",

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Kok, END, Eppenga, R, Kuhlmann, KFD, Groen, HC, van Veen, R, van Dieren, JM, de Wijkerslooth, TR, van Leerdam, M, Lambregts, DMJ, Heerink, WJ, Hoetjes, NJ, Ivashchenko, O, Beets, GL, Aalbers, AGJ, Nijkamp, J & Ruers, TJM 2020, 'Accurate surgical navigation with real-time tumor tracking in cancer surgery', npj Precision Oncology, vol. 4, no. 1, 8. https://doi.org/10.1038/s41698-020-0115-0

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AU - van Veen, Ruben

AU - van Dieren, Jolanda M.

AU - de Wijkerslooth, Thomas R.

AU - van Leerdam, Monique

AU - Lambregts, Doenja M.J.

AU - Heerink, Wouter J.

AU - Hoetjes, Nikie J.

AU - Ivashchenko, Oleksandra

AU - Beets, Geerard L.

AU - Aalbers, Arend G.J.

AU - Nijkamp, Jasper

AU - Ruers, Theo J.M.

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Accurate surgical navigation with real-time tumor tracking in cancer surgery

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