Acetylcholine addition and electrical stimulation of dissociated neurons from an extended subthalamic area - A pilot study in the rat

    Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

    Abstract

    Addition of acetylcholine to cultures of STN area's (5 steps of 10 uM with a step interval of 1000s) show a direct and longlasting reduction of STN activity. Low frequency stimulation (20 Hz, 500 block pulses) increases STN activity, while high frequency stimulation (80 Hz, 2000 block pulses) reduces STN activity, even after the stimulation period of 25 seconds.
    Original languageEnglish
    Title of host publication11th Mediterranean Conference on Medical and Biomedical Engineering and Computing 2007
    Subtitle of host publicationMEDICON 2007, 26-30 June 2007, Ljubljana, Slovenia
    EditorsT. Jarm, P. Kramar, A. Zupanic
    Place of PublicationLondon
    PublisherSpringer
    Pages521-524
    Number of pages4
    ISBN (Electronic)978-3-540-73044-6
    ISBN (Print)978-3-540-73043-9
    DOIs
    Publication statusPublished - 30 Jun 2007
    Event11th Mediterranean Conference on Medical and Biomedical Engineering and Computing, MEDICON 2007 - Ljubljana, Slovenia
    Duration: 26 Jun 200730 Jun 2007
    Conference number: 11

    Publication series

    NameIFMBE Proceedings
    PublisherSpringer Verlag
    Volume16
    ISSN (Print)1727-1983

    Conference

    Conference11th Mediterranean Conference on Medical and Biomedical Engineering and Computing, MEDICON 2007
    Abbreviated titleMEDICON
    CountrySlovenia
    CityLjubljana
    Period26/06/0730/06/07

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    Keywords

    • BSS-Neurotechnology and cellular engineering
    • STN
    • acetylcholine
    • METIS-241750
    • EWI-10407
    • IR-61780
    • Electrical stimulation

    Cite this

    Heida, T., Usunoff, K. G., & Marani, E. (2007). Acetylcholine addition and electrical stimulation of dissociated neurons from an extended subthalamic area - A pilot study in the rat. In T. Jarm, P. Kramar, & A. Zupanic (Eds.), 11th Mediterranean Conference on Medical and Biomedical Engineering and Computing 2007: MEDICON 2007, 26-30 June 2007, Ljubljana, Slovenia (pp. 521-524). (IFMBE Proceedings; Vol. 16). London: Springer. https://doi.org/10.1007/978-3-540-73044-6_133