Acetylcholine addition and electrical stimulation of dissociated neurons from an extended subthalamic area - A pilot study in the rat

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Abstract

Addition of acetylcholine to cultures of STN area's (5 steps of 10 uM with a step interval of 1000s) show a direct and longlasting reduction of STN activity. Low frequency stimulation (20 Hz, 500 block pulses) increases STN activity, while high frequency stimulation (80 Hz, 2000 block pulses) reduces STN activity, even after the stimulation period of 25 seconds.
Original languageEnglish
Title of host publication11th Mediterranean Conference on Medical and Biomedical Engineering and Computing 2007
Subtitle of host publicationMEDICON 2007, 26-30 June 2007, Ljubljana, Slovenia
EditorsT. Jarm, P. Kramar, A. Zupanic
Place of PublicationLondon
PublisherSpringer
Pages521-524
Number of pages4
ISBN (Electronic)978-3-540-73044-6
ISBN (Print)978-3-540-73043-9
DOIs
Publication statusPublished - 30 Jun 2007
Event11th Mediterranean Conference on Medical and Biomedical Engineering and Computing, MEDICON 2007 - Ljubljana, Slovenia
Duration: 26 Jun 200730 Jun 2007
Conference number: 11

Publication series

NameIFMBE Proceedings
PublisherSpringer Verlag
Volume16
ISSN (Print)1727-1983

Conference

Conference11th Mediterranean Conference on Medical and Biomedical Engineering and Computing, MEDICON 2007
Abbreviated titleMEDICON
CountrySlovenia
CityLjubljana
Period26/06/0730/06/07

Fingerprint

Electric Stimulation
Acetylcholine
Neurons

Keywords

  • BSS-Neurotechnology and cellular engineering
  • STN
  • acetylcholine
  • METIS-241750
  • EWI-10407
  • IR-61780
  • Electrical stimulation

Cite this

Heida, T., Usunoff, K. G., & Marani, E. (2007). Acetylcholine addition and electrical stimulation of dissociated neurons from an extended subthalamic area - A pilot study in the rat. In T. Jarm, P. Kramar, & A. Zupanic (Eds.), 11th Mediterranean Conference on Medical and Biomedical Engineering and Computing 2007: MEDICON 2007, 26-30 June 2007, Ljubljana, Slovenia (pp. 521-524). (IFMBE Proceedings; Vol. 16). London: Springer. https://doi.org/10.1007/978-3-540-73044-6_133
Heida, Tjitske ; Usunoff, K.G. ; Marani, Enrico. / Acetylcholine addition and electrical stimulation of dissociated neurons from an extended subthalamic area - A pilot study in the rat. 11th Mediterranean Conference on Medical and Biomedical Engineering and Computing 2007: MEDICON 2007, 26-30 June 2007, Ljubljana, Slovenia. editor / T. Jarm ; P. Kramar ; A. Zupanic. London : Springer, 2007. pp. 521-524 (IFMBE Proceedings).
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abstract = "Addition of acetylcholine to cultures of STN area's (5 steps of 10 uM with a step interval of 1000s) show a direct and longlasting reduction of STN activity. Low frequency stimulation (20 Hz, 500 block pulses) increases STN activity, while high frequency stimulation (80 Hz, 2000 block pulses) reduces STN activity, even after the stimulation period of 25 seconds.",
keywords = "BSS-Neurotechnology and cellular engineering, STN, acetylcholine, METIS-241750, EWI-10407, IR-61780, Electrical stimulation",
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Heida, T, Usunoff, KG & Marani, E 2007, Acetylcholine addition and electrical stimulation of dissociated neurons from an extended subthalamic area - A pilot study in the rat. in T Jarm, P Kramar & A Zupanic (eds), 11th Mediterranean Conference on Medical and Biomedical Engineering and Computing 2007: MEDICON 2007, 26-30 June 2007, Ljubljana, Slovenia. IFMBE Proceedings, vol. 16, Springer, London, pp. 521-524, 11th Mediterranean Conference on Medical and Biomedical Engineering and Computing, MEDICON 2007, Ljubljana, Slovenia, 26/06/07. https://doi.org/10.1007/978-3-540-73044-6_133

Acetylcholine addition and electrical stimulation of dissociated neurons from an extended subthalamic area - A pilot study in the rat. / Heida, Tjitske; Usunoff, K.G.; Marani, Enrico.

11th Mediterranean Conference on Medical and Biomedical Engineering and Computing 2007: MEDICON 2007, 26-30 June 2007, Ljubljana, Slovenia. ed. / T. Jarm; P. Kramar; A. Zupanic. London : Springer, 2007. p. 521-524 (IFMBE Proceedings; Vol. 16).

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

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AB - Addition of acetylcholine to cultures of STN area's (5 steps of 10 uM with a step interval of 1000s) show a direct and longlasting reduction of STN activity. Low frequency stimulation (20 Hz, 500 block pulses) increases STN activity, while high frequency stimulation (80 Hz, 2000 block pulses) reduces STN activity, even after the stimulation period of 25 seconds.

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KW - IR-61780

KW - Electrical stimulation

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Heida T, Usunoff KG, Marani E. Acetylcholine addition and electrical stimulation of dissociated neurons from an extended subthalamic area - A pilot study in the rat. In Jarm T, Kramar P, Zupanic A, editors, 11th Mediterranean Conference on Medical and Biomedical Engineering and Computing 2007: MEDICON 2007, 26-30 June 2007, Ljubljana, Slovenia. London: Springer. 2007. p. 521-524. (IFMBE Proceedings). https://doi.org/10.1007/978-3-540-73044-6_133