Acetylcholine addition and electrical stimulation of dissociated neurons from an extended subthalamic area - A pilot study in the rat

Tjitske Heida; K.G. Usunoff; Enrico Marani

doi:10.1007/978-3-540-73044-6_133

Acetylcholine addition and electrical stimulation of dissociated neurons from an extended subthalamic area - A pilot study in the rat

Tjitske Heida
, K.G. Usunoff
, Enrico Marani

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

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Abstract

Addition of acetylcholine to cultures of STN area's (5 steps of 10 uM with a step interval of 1000s) show a direct and longlasting reduction of STN activity. Low frequency stimulation (20 Hz, 500 block pulses) increases STN activity, while high frequency stimulation (80 Hz, 2000 block pulses) reduces STN activity, even after the stimulation period of 25 seconds.

Original language	English
Title of host publication	11th Mediterranean Conference on Medical and Biomedical Engineering and Computing 2007
Subtitle of host publication	MEDICON 2007, 26-30 June 2007, Ljubljana, Slovenia
Editors	T. Jarm, P. Kramar, A. Zupanic
Place of Publication	London
Publisher	Springer
Pages	521-524
Number of pages	4
ISBN (Electronic)	978-3-540-73044-6
ISBN (Print)	978-3-540-73043-9
DOIs	https://doi.org/10.1007/978-3-540-73044-6_133
Publication status	Published - 30 Jun 2007
Event	11th Mediterranean Conference on Medical and Biomedical Engineering and Computing, MEDICON 2007 - Ljubljana, Slovenia Duration: 26 Jun 2007 → 30 Jun 2007 Conference number: 11

Publication series

Name	IFMBE Proceedings
Publisher	Springer Verlag
Volume	16
ISSN (Print)	1727-1983

Conference

Conference	11th Mediterranean Conference on Medical and Biomedical Engineering and Computing, MEDICON 2007
Abbreviated title	MEDICON
Country/Territory	Slovenia
City	Ljubljana
Period	26/06/07 → 30/06/07

Keywords

BSS-Neurotechnology and cellular engineering
STN
acetylcholine
METIS-241750
EWI-10407
IR-61780
Electrical stimulation

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10.1007/978-3-540-73044-6_133

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Heida, T., Usunoff, K. G., & Marani, E. (2007). Acetylcholine addition and electrical stimulation of dissociated neurons from an extended subthalamic area - A pilot study in the rat. In T. Jarm, P. Kramar, & A. Zupanic (Eds.), 11th Mediterranean Conference on Medical and Biomedical Engineering and Computing 2007: MEDICON 2007, 26-30 June 2007, Ljubljana, Slovenia (pp. 521-524). (IFMBE Proceedings; Vol. 16). Springer. https://doi.org/10.1007/978-3-540-73044-6_133

Heida, Tjitske ; Usunoff, K.G. ; Marani, Enrico. / Acetylcholine addition and electrical stimulation of dissociated neurons from an extended subthalamic area - A pilot study in the rat. 11th Mediterranean Conference on Medical and Biomedical Engineering and Computing 2007: MEDICON 2007, 26-30 June 2007, Ljubljana, Slovenia. editor / T. Jarm ; P. Kramar ; A. Zupanic. London : Springer, 2007. pp. 521-524 (IFMBE Proceedings).

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title = "Acetylcholine addition and electrical stimulation of dissociated neurons from an extended subthalamic area - A pilot study in the rat",

abstract = "Addition of acetylcholine to cultures of STN area's (5 steps of 10 uM with a step interval of 1000s) show a direct and longlasting reduction of STN activity. Low frequency stimulation (20 Hz, 500 block pulses) increases STN activity, while high frequency stimulation (80 Hz, 2000 block pulses) reduces STN activity, even after the stimulation period of 25 seconds.",

keywords = "BSS-Neurotechnology and cellular engineering, STN, acetylcholine, METIS-241750, EWI-10407, IR-61780, Electrical stimulation",

author = "Tjitske Heida and K.G. Usunoff and Enrico Marani",

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editor = "T. Jarm and P. Kramar and A. Zupanic",

booktitle = "11th Mediterranean Conference on Medical and Biomedical Engineering and Computing 2007",

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note = "11th Mediterranean Conference on Medical and Biomedical Engineering and Computing, MEDICON 2007, MEDICON ; Conference date: 26-06-2007 Through 30-06-2007",

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Heida, T, Usunoff, KG & Marani, E 2007, Acetylcholine addition and electrical stimulation of dissociated neurons from an extended subthalamic area - A pilot study in the rat. in T Jarm, P Kramar & A Zupanic (eds), 11th Mediterranean Conference on Medical and Biomedical Engineering and Computing 2007: MEDICON 2007, 26-30 June 2007, Ljubljana, Slovenia. IFMBE Proceedings, vol. 16, Springer, London, pp. 521-524, 11th Mediterranean Conference on Medical and Biomedical Engineering and Computing, MEDICON 2007, Ljubljana, Slovenia, 26/06/07. https://doi.org/10.1007/978-3-540-73044-6_133

Acetylcholine addition and electrical stimulation of dissociated neurons from an extended subthalamic area - A pilot study in the rat. / Heida, Tjitske; Usunoff, K.G.; Marani, Enrico.
11th Mediterranean Conference on Medical and Biomedical Engineering and Computing 2007: MEDICON 2007, 26-30 June 2007, Ljubljana, Slovenia. ed. / T. Jarm; P. Kramar; A. Zupanic. London: Springer, 2007. p. 521-524 (IFMBE Proceedings; Vol. 16).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

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T1 - Acetylcholine addition and electrical stimulation of dissociated neurons from an extended subthalamic area - A pilot study in the rat

AU - Heida, Tjitske

AU - Usunoff, K.G.

AU - Marani, Enrico

N1 - Conference code: 11

PY - 2007/6/30

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N2 - Addition of acetylcholine to cultures of STN area's (5 steps of 10 uM with a step interval of 1000s) show a direct and longlasting reduction of STN activity. Low frequency stimulation (20 Hz, 500 block pulses) increases STN activity, while high frequency stimulation (80 Hz, 2000 block pulses) reduces STN activity, even after the stimulation period of 25 seconds.

AB - Addition of acetylcholine to cultures of STN area's (5 steps of 10 uM with a step interval of 1000s) show a direct and longlasting reduction of STN activity. Low frequency stimulation (20 Hz, 500 block pulses) increases STN activity, while high frequency stimulation (80 Hz, 2000 block pulses) reduces STN activity, even after the stimulation period of 25 seconds.

KW - BSS-Neurotechnology and cellular engineering

KW - STN

KW - acetylcholine

KW - METIS-241750

KW - EWI-10407

KW - IR-61780

KW - Electrical stimulation

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DO - 10.1007/978-3-540-73044-6_133

M3 - Conference contribution

SN - 978-3-540-73043-9

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BT - 11th Mediterranean Conference on Medical and Biomedical Engineering and Computing 2007

A2 - Jarm, T.

A2 - Kramar, P.

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T2 - 11th Mediterranean Conference on Medical and Biomedical Engineering and Computing, MEDICON 2007

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Heida T, Usunoff KG, Marani E. Acetylcholine addition and electrical stimulation of dissociated neurons from an extended subthalamic area - A pilot study in the rat. In Jarm T, Kramar P, Zupanic A, editors, 11th Mediterranean Conference on Medical and Biomedical Engineering and Computing 2007: MEDICON 2007, 26-30 June 2007, Ljubljana, Slovenia. London: Springer. 2007. p. 521-524. (IFMBE Proceedings). doi: 10.1007/978-3-540-73044-6_133

Acetylcholine addition and electrical stimulation of dissociated neurons from an extended subthalamic area - A pilot study in the rat

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