Acoustic bubble sorting of ultrasound contrast agents

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Abstract

Ultrasound contrast agents resonate to the driving pressure pulse transmitted by the clinical ultrasound system. These systems operate at a narrow bandwidth optimized for the ultrasound transducer. Due to the large size distribution of commercially available UCA only a small selection of bubbles contribute to the echo signal. Thus the sensitivity in diagnostic imaging can be improved by narrowing down the size distribution. We present a novel lab-on-a-chip bubble-sorting method based on the acoustic forcing of microbubbles. A bubble in a traveling pressure wave experiences a net acoustic radiation force that pushes the bubble in the direction of wave propagation. The magnitude of the radiation force is bubble size-dependent through resonance; bubbles close to resonance experience the largest force1. We use this acoustic radiation force to sort bubbles in a microfluidic channel made in polydimethylsiloxane (PDMS) with an embedded piezo transducer.
Original languageEnglish
Publication statusPublished - 17 Jul 2013
EventLeeds Microbubble Symposium 2013: Fabrication, Characterisation and Translational Applications - Leeds, United Kingdom
Duration: 17 Jul 201318 Jul 2013

Conference

ConferenceLeeds Microbubble Symposium 2013
CountryUnited Kingdom
CityLeeds
Period17/07/1318/07/13

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