Acoustic bubble sorting of ultrasound contrast agents

Research output: Contribution to conferencePosterAcademic

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Abstract

Ultrasound contrast agents resonate to the driving pressure pulse transmitted by the clinical ultrasound system. These systems operate at a narrow bandwidth optimized for the ultrasound transducer. Due to the large size distribution of commercially available UCA only a small selection of bubbles contribute to the echo signal. Thus the sensitivity in diagnostic imaging can be improved by narrowing down the size distribution. We present a novel lab-on-a-chip bubble-sorting method based on the acoustic forcing of microbubbles. A bubble in a traveling pressure wave experiences a net acoustic radiation force that pushes the bubble in the direction of wave propagation. The magnitude of the radiation force is bubble size-dependent through resonance; bubbles close to resonance experience the largest force1. We use this acoustic radiation force to sort bubbles in a microfluidic channel made in polydimethylsiloxane (PDMS) with an embedded piezo transducer.
Original languageEnglish
Publication statusPublished - 17 Jul 2013
EventLeeds Microbubble Symposium 2013: Fabrication, Characterisation and Translational Applications - Leeds, United Kingdom
Duration: 17 Jul 201318 Jul 2013

Conference

ConferenceLeeds Microbubble Symposium 2013
CountryUnited Kingdom
CityLeeds
Period17/07/1318/07/13

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classifying
bubbles
acoustics
sound waves
transducers
pressure pulses
elastic waves
wave propagation
echoes
chips
bandwidth
sensitivity
radiation

Cite this

Segers, T. (2013). Acoustic bubble sorting of ultrasound contrast agents. Poster session presented at Leeds Microbubble Symposium 2013, Leeds, United Kingdom.
Segers, Tim. / Acoustic bubble sorting of ultrasound contrast agents. Poster session presented at Leeds Microbubble Symposium 2013, Leeds, United Kingdom.
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Segers, T 2013, 'Acoustic bubble sorting of ultrasound contrast agents' Leeds Microbubble Symposium 2013, Leeds, United Kingdom, 17/07/13 - 18/07/13, .

Acoustic bubble sorting of ultrasound contrast agents. / Segers, Tim.

2013. Poster session presented at Leeds Microbubble Symposium 2013, Leeds, United Kingdom.

Research output: Contribution to conferencePosterAcademic

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T1 - Acoustic bubble sorting of ultrasound contrast agents

AU - Segers, Tim

PY - 2013/7/17

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N2 - Ultrasound contrast agents resonate to the driving pressure pulse transmitted by the clinical ultrasound system. These systems operate at a narrow bandwidth optimized for the ultrasound transducer. Due to the large size distribution of commercially available UCA only a small selection of bubbles contribute to the echo signal. Thus the sensitivity in diagnostic imaging can be improved by narrowing down the size distribution. We present a novel lab-on-a-chip bubble-sorting method based on the acoustic forcing of microbubbles. A bubble in a traveling pressure wave experiences a net acoustic radiation force that pushes the bubble in the direction of wave propagation. The magnitude of the radiation force is bubble size-dependent through resonance; bubbles close to resonance experience the largest force1. We use this acoustic radiation force to sort bubbles in a microfluidic channel made in polydimethylsiloxane (PDMS) with an embedded piezo transducer.

AB - Ultrasound contrast agents resonate to the driving pressure pulse transmitted by the clinical ultrasound system. These systems operate at a narrow bandwidth optimized for the ultrasound transducer. Due to the large size distribution of commercially available UCA only a small selection of bubbles contribute to the echo signal. Thus the sensitivity in diagnostic imaging can be improved by narrowing down the size distribution. We present a novel lab-on-a-chip bubble-sorting method based on the acoustic forcing of microbubbles. A bubble in a traveling pressure wave experiences a net acoustic radiation force that pushes the bubble in the direction of wave propagation. The magnitude of the radiation force is bubble size-dependent through resonance; bubbles close to resonance experience the largest force1. We use this acoustic radiation force to sort bubbles in a microfluidic channel made in polydimethylsiloxane (PDMS) with an embedded piezo transducer.

M3 - Poster

ER -

Segers T. Acoustic bubble sorting of ultrasound contrast agents. 2013. Poster session presented at Leeds Microbubble Symposium 2013, Leeds, United Kingdom.