Activity patterns of cultured neural networks on micro electrode arrays

Wim Rutten, J. van Pelt

    Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

    2 Citations (Scopus)
    47 Downloads (Pure)

    Abstract

    A hybrid neuro-electronic interface is a cell-cultured micro electrode array, acting as a neural information transducer for stimulation and/or recording of neural activity in the brain or the spinal cord (ventral motor region or dorsal sensory region). It consists of an array of micro electrodes on a planar substrate, the electrodes being covered by a network of cultured neurons. The cultured neuron network layer acts as a natural host for in vivo neural connections. Besides this function, live neural networks can become spontaneously active and have the capability of information processing, as 'minibrains'. One may envisage future applications of these intermediary networks as 'front-end' signal processors. The paper presents results on spatio-temporal activity patterns and their characterization in neural networks, cultured from dissociated rat visual cortex. Cultures lasted 43 days in vitro on multi electrode plates with 60 electrode sites and started activity after about seven days. Firing rates increase with time thereafter. Typical 'pacemaker'-and-burst firing patterns are seen, the time characteristics of which change over days, typically.
    Original languageUndefined
    Title of host publicationProceedings 23rd International Conference of the IEEE Engineering in Medicine and Biology Society, Istanbul, Turkey
    Place of PublicationPiscattaway, USA
    PublisherIEEE
    Pages-
    Number of pages4
    ISBN (Print)0-7803-7213-1
    Publication statusPublished - 25 Oct 2001
    Event23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2001 - Istanbul, Turkey
    Duration: 25 Oct 200128 Oct 2001
    Conference number: 23

    Publication series

    Name
    PublisherIEEE
    Volume1

    Conference

    Conference23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2001
    Abbreviated titleEMBC
    CountryTurkey
    CityIstanbul
    Period25/10/0128/10/01

    Keywords

    • METIS-200710
    • IR-42183

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