ADAMTS13 and von Willebrand factor and the risk of myocardial infarction in men

Chan K.N.K. Chion; Carine J.M. Doggen; James T.B. Crawley; David A. Lane; Frits R. Rosendaal

doi:10.1182/blood-2006-07-038166

ADAMTS13 and von Willebrand factor and the risk of myocardial infarction in men

Chan K.N.K. Chion, Carine J.M. Doggen, James T.B. Crawley, David A. Lane, Frits R. Rosendaal

Research output: Contribution to journal › Article › Academic › peer-review

110 Citations (Scopus)

Abstract

Von Willebrand factor (VWF) mediates the tethering/adhesion of platelets at sites of vascular injury. This function depends on its multimeric size, which is controlled by ADAMTS13. We measured plasma ADAMTS13 and VWF antigen levels by enzyme-linked immunosorbent assay (ELISA) in a large population-based case-control study (Study of Myocardial Infarctions Leiden [SMILE]), consisting of 560 men with a first myocardial infarction (MI) and 646 control subjects. Although ABO blood groups influenced VWF levels, they had no influence on ADAMTS13. Furthermore, there was no relationship between plasma ADAMTS13 and VWF levels. Similar to VWF, the estimated risk of MI was increased for every quartile of ADAMTS13 when compared to the lowest quartile (odds ratio, 1.5-1.6). If confirmed, the association of ADAMTS13 with MI may suggest an unexpected mechanistic action of ADAMTS13

Original language	English
Pages (from-to)	1998-2000
Journal	Blood
Volume	109
Issue number	5
DOIs	https://doi.org/10.1182/blood-2006-07-038166
Publication status	Published - 2007
Externally published	Yes

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title = "ADAMTS13 and von Willebrand factor and the risk of myocardial infarction in men",

abstract = "Von Willebrand factor (VWF) mediates the tethering/adhesion of platelets at sites of vascular injury. This function depends on its multimeric size, which is controlled by ADAMTS13. We measured plasma ADAMTS13 and VWF antigen levels by enzyme-linked immunosorbent assay (ELISA) in a large population-based case-control study (Study of Myocardial Infarctions Leiden [SMILE]), consisting of 560 men with a first myocardial infarction (MI) and 646 control subjects. Although ABO blood groups influenced VWF levels, they had no influence on ADAMTS13. Furthermore, there was no relationship between plasma ADAMTS13 and VWF levels. Similar to VWF, the estimated risk of MI was increased for every quartile of ADAMTS13 when compared to the lowest quartile (odds ratio, 1.5-1.6). If confirmed, the association of ADAMTS13 with MI may suggest an unexpected mechanistic action of ADAMTS13",

author = "Chion, {Chan K.N.K.} and Doggen, {Carine J.M.} and Crawley, {James T.B.} and Lane, {David A.} and Rosendaal, {Frits R.}",

year = "2007",

doi = "10.1182/blood-2006-07-038166",

language = "English",

volume = "109",

pages = "1998--2000",

journal = "Blood",

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T1 - ADAMTS13 and von Willebrand factor and the risk of myocardial infarction in men

AU - Chion, Chan K.N.K.

AU - Doggen, Carine J.M.

AU - Crawley, James T.B.

AU - Lane, David A.

AU - Rosendaal, Frits R.

PY - 2007

Y1 - 2007

N2 - Von Willebrand factor (VWF) mediates the tethering/adhesion of platelets at sites of vascular injury. This function depends on its multimeric size, which is controlled by ADAMTS13. We measured plasma ADAMTS13 and VWF antigen levels by enzyme-linked immunosorbent assay (ELISA) in a large population-based case-control study (Study of Myocardial Infarctions Leiden [SMILE]), consisting of 560 men with a first myocardial infarction (MI) and 646 control subjects. Although ABO blood groups influenced VWF levels, they had no influence on ADAMTS13. Furthermore, there was no relationship between plasma ADAMTS13 and VWF levels. Similar to VWF, the estimated risk of MI was increased for every quartile of ADAMTS13 when compared to the lowest quartile (odds ratio, 1.5-1.6). If confirmed, the association of ADAMTS13 with MI may suggest an unexpected mechanistic action of ADAMTS13

AB - Von Willebrand factor (VWF) mediates the tethering/adhesion of platelets at sites of vascular injury. This function depends on its multimeric size, which is controlled by ADAMTS13. We measured plasma ADAMTS13 and VWF antigen levels by enzyme-linked immunosorbent assay (ELISA) in a large population-based case-control study (Study of Myocardial Infarctions Leiden [SMILE]), consisting of 560 men with a first myocardial infarction (MI) and 646 control subjects. Although ABO blood groups influenced VWF levels, they had no influence on ADAMTS13. Furthermore, there was no relationship between plasma ADAMTS13 and VWF levels. Similar to VWF, the estimated risk of MI was increased for every quartile of ADAMTS13 when compared to the lowest quartile (odds ratio, 1.5-1.6). If confirmed, the association of ADAMTS13 with MI may suggest an unexpected mechanistic action of ADAMTS13

U2 - 10.1182/blood-2006-07-038166

DO - 10.1182/blood-2006-07-038166

M3 - Article

SN - 0006-4971

VL - 109

SP - 1998

EP - 2000

JO - Blood

JF - Blood

IS - 5

ER -

ADAMTS13 and von Willebrand factor and the risk of myocardial infarction in men

Abstract

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