Adaptive radiotherapy for breast cancer

C. De-Colle; A. Kirby; N. Russell; S.F. Shaitelman; A. Currey; E. Donovan; E. Hahn; K. Han; C.N. Anandadas; F. Mahmood; E.L. Lorenzen; H.J.G. Desiree van den Bongard; M.L. Groot Koerkamp; A.C. Houweling; M. Nachbar; D. Thorwarth; D. Zips

doi:10.1016/j.ctro.2022.100564

Adaptive radiotherapy for breast cancer

C. De-Colle^*, A. Kirby, N. Russell, S.F. Shaitelman, A. Currey, E. Donovan, E. Hahn, K. Han, C.N. Anandadas, F. Mahmood, E.L. Lorenzen, H.J.G. Desiree van den Bongard, M.L. Groot Koerkamp, A.C. Houweling, M. Nachbar, D. Thorwarth, D. Zips

^*Corresponding author for this work

Research output: Contribution to journal › Review article › Academic › peer-review

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Abstract

Research in the field of local and locoregional breast cancer radiotherapy aims to maintain excellent oncological outcomes while reducing treatment-related toxicity. Adaptive radiotherapy (ART) considers variations in target and organs at risk (OARs) anatomy occurring during the treatment course and integrates these in re-optimized treatment plans. Exploiting ART routinely in clinic may result in smaller target volumes and better OAR sparing, which may lead to reduction of acute as well as late toxicities. In this review MR-guided and CT-guided ART for breast cancer patients according to different clinical scenarios (neoadjuvant and adjuvant partial breast irradiation, whole breast, chest wall and regional nodal irradiation) are reviewed and their advantages as well as challenging aspects discussed.

Original language	English
Article number	100564
Journal	Clinical and Translational Radiation Oncology
Volume	39
DOIs	https://doi.org/10.1016/j.ctro.2022.100564
Publication status	Published - Mar 2023
Externally published	Yes

Keywords

Adaptive radiotherapy
Breast cancer
MR-linac
Partial breast irradiation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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De-Colle, C., Kirby, A., Russell, N., Shaitelman, S. F., Currey, A., Donovan, E., Hahn, E., Han, K., Anandadas, C. N., Mahmood, F., Lorenzen, E. L., Bongard, H. J. G. D. V. D., Groot Koerkamp, M. L., Houweling, A. C., Nachbar, M., Thorwarth, D., & Zips, D. (2023). Adaptive radiotherapy for breast cancer. Clinical and Translational Radiation Oncology, 39, Article 100564. https://doi.org/10.1016/j.ctro.2022.100564

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author = "C. De-Colle and A. Kirby and N. Russell and S.F. Shaitelman and A. Currey and E. Donovan and E. Hahn and K. Han and C.N. Anandadas and F. Mahmood and E.L. Lorenzen and Bongard, {H.J.G. Desiree van den} and {Groot Koerkamp}, M.L. and A.C. Houweling and M. Nachbar and D. Thorwarth and D. Zips",

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doi = "10.1016/j.ctro.2022.100564",

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De-Colle, C, Kirby, A, Russell, N, Shaitelman, SF, Currey, A, Donovan, E, Hahn, E, Han, K, Anandadas, CN, Mahmood, F, Lorenzen, EL, Bongard, HJGDVD, Groot Koerkamp, ML, Houweling, AC, Nachbar, M, Thorwarth, D & Zips, D 2023, 'Adaptive radiotherapy for breast cancer', Clinical and Translational Radiation Oncology, vol. 39, 100564. https://doi.org/10.1016/j.ctro.2022.100564

TY - JOUR

T1 - Adaptive radiotherapy for breast cancer

AU - De-Colle, C.

AU - Kirby, A.

AU - Russell, N.

AU - Shaitelman, S.F.

AU - Currey, A.

AU - Donovan, E.

AU - Hahn, E.

AU - Han, K.

AU - Anandadas, C.N.

AU - Mahmood, F.

AU - Lorenzen, E.L.

AU - Bongard, H.J.G. Desiree van den

AU - Groot Koerkamp, M.L.

AU - Houweling, A.C.

AU - Nachbar, M.

AU - Thorwarth, D.

AU - Zips, D.

PY - 2023/3

Y1 - 2023/3

N2 - Research in the field of local and locoregional breast cancer radiotherapy aims to maintain excellent oncological outcomes while reducing treatment-related toxicity. Adaptive radiotherapy (ART) considers variations in target and organs at risk (OARs) anatomy occurring during the treatment course and integrates these in re-optimized treatment plans. Exploiting ART routinely in clinic may result in smaller target volumes and better OAR sparing, which may lead to reduction of acute as well as late toxicities. In this review MR-guided and CT-guided ART for breast cancer patients according to different clinical scenarios (neoadjuvant and adjuvant partial breast irradiation, whole breast, chest wall and regional nodal irradiation) are reviewed and their advantages as well as challenging aspects discussed.

AB - Research in the field of local and locoregional breast cancer radiotherapy aims to maintain excellent oncological outcomes while reducing treatment-related toxicity. Adaptive radiotherapy (ART) considers variations in target and organs at risk (OARs) anatomy occurring during the treatment course and integrates these in re-optimized treatment plans. Exploiting ART routinely in clinic may result in smaller target volumes and better OAR sparing, which may lead to reduction of acute as well as late toxicities. In this review MR-guided and CT-guided ART for breast cancer patients according to different clinical scenarios (neoadjuvant and adjuvant partial breast irradiation, whole breast, chest wall and regional nodal irradiation) are reviewed and their advantages as well as challenging aspects discussed.

KW - Adaptive radiotherapy

KW - Breast cancer

KW - MR-linac

KW - Partial breast irradiation

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U2 - 10.1016/j.ctro.2022.100564

DO - 10.1016/j.ctro.2022.100564

M3 - Review article

AN - SCOPUS:85146009085

SN - 2405-6308

VL - 39

JO - Clinical and Translational Radiation Oncology

JF - Clinical and Translational Radiation Oncology

M1 - 100564

ER -

Adaptive radiotherapy for breast cancer

Abstract

Keywords

UN SDGs

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