Adding patient motion from DCE-MRI to anthropomorphic phantoms for dedicated breast CT

Mikhail Mikerov*, Koen Michelsen, Nikita Moriakov, Ioannis Sechopoulos

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

26 Downloads (Pure)


Extending dedicated breast CT to dynamic contrast-enhanced breast CT will allow functional data by following contrast distribution over multiple time points. As a result of longer scans, unwanted patient motion becomes more likely and motion correction is necessary to avoid artifacts. A crucial part of the development of a motion compensation method is its validation on data with known ground truth. Thus, anthropomorphic phantoms with realistic motion patterns are needed. We present a method to combine motion vector fields, extracted from dynamic contrast-enhanced breast magnetic resonance imaging (DCE-MRI), with digital breast phantoms. DCE-MRI is an ideal source for these data due to its frequent clinical use and a similar prone patient positioning compared to breast CT. Our algorithm consists of three steps. First, the inter-scan motion vector fields are obtained by registration of consecutive images in the DCE-MRI sequence. In the second stage, the digital breast phantoms are aligned on MRI scans using an affine transformation. Finally, the obtained motion vector fields are transformed and applied to the phantoms after parameterization such that the total motion is distributed smoothly in time. The applied motion is evaluated in reconstructions of the simulated breast CT acquisition by qualitative comparison to clinical cases with intra-scan motion. We show that phantoms with simulated motion exhibit the same artifacts as in clinical data such as smooth transitions at the tissue interfaces and ghosting of fine structures.

Original languageEnglish
Title of host publicationMedical Imaging 2022
Subtitle of host publicationImage Processing
EditorsOlivier Colliot, Ivana Isgum, Bennett A. Landman, Murray H. Loew
ISBN (Electronic)9781510649392
Publication statusPublished - 4 Apr 2022
Externally publishedYes
EventMedical Imaging 2022: Physics of Medical Imaging - Virtual, Online
Duration: 21 Mar 202227 Mar 2022

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceMedical Imaging 2022: Physics of Medical Imaging
CityVirtual, Online


  • breast CT
  • Digital phantoms
  • motion


Dive into the research topics of 'Adding patient motion from DCE-MRI to anthropomorphic phantoms for dedicated breast CT'. Together they form a unique fingerprint.

Cite this