Adriamycin loading and release characteristics of albumin-heparin conjugate microspheres

H.F.M. Cremers, R. Verrijk, H.P.J.M. Noteborn, G. Kwon, Y.H. Bae, S.W. Kim, Jan Feijen

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Abstract

Biodegradable ion-exchange microspheres, prepared from a prefabricated conjugate of albumin and heparin were investigated as carriers for adriamycin. The ion-exchange microspheres could be loaded with adriamycin giving payloads up to 33% w/w, depending on the heparin content of the conjugate. In vitro adriamycin release depended on the ionic strength of the release medium. In ion containing media, for instance saline, 90% of the drug was released within 45 min, whereas in non-ionic media, such as distilled water, only 30% was released. Drug release profiles could be modelled by combining ion-exchange kinetics and diffusion controlled drug release models.
Original languageEnglish
Pages (from-to)143-155
JournalJournal of controlled release
Volume1994
Issue number29
DOIs
Publication statusPublished - 1994

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    Cremers, H. F. M., Verrijk, R., Noteborn, H. P. J. M., Kwon, G., Bae, Y. H., Kim, S. W., & Feijen, J. (1994). Adriamycin loading and release characteristics of albumin-heparin conjugate microspheres. Journal of controlled release, 1994(29), 143-155. https://doi.org/10.1016/0168-3659(94)90130-9