TY - JOUR
T1 - Adriamycin loading and release characteristics of albumin-heparin conjugate microspheres
AU - Cremers, H.F.M.
AU - Verrijk, R.
AU - Noteborn, H.P.J.M.
AU - Kwon, G.
AU - Bae, Y.H.
AU - Kim, S.W.
AU - Feijen, Jan
PY - 1994
Y1 - 1994
N2 - Biodegradable ion-exchange microspheres, prepared from a prefabricated conjugate of albumin and heparin were investigated as carriers for adriamycin. The ion-exchange microspheres could be loaded with adriamycin giving payloads up to 33% w/w, depending on the heparin content of the conjugate. In vitro adriamycin release depended on the ionic strength of the release medium. In ion containing media, for instance saline, 90% of the drug was released within 45 min, whereas in non-ionic media, such as distilled water, only 30% was released. Drug release profiles could be modelled by combining ion-exchange kinetics and diffusion controlled drug release models.
AB - Biodegradable ion-exchange microspheres, prepared from a prefabricated conjugate of albumin and heparin were investigated as carriers for adriamycin. The ion-exchange microspheres could be loaded with adriamycin giving payloads up to 33% w/w, depending on the heparin content of the conjugate. In vitro adriamycin release depended on the ionic strength of the release medium. In ion containing media, for instance saline, 90% of the drug was released within 45 min, whereas in non-ionic media, such as distilled water, only 30% was released. Drug release profiles could be modelled by combining ion-exchange kinetics and diffusion controlled drug release models.
U2 - 10.1016/0168-3659(94)90130-9
DO - 10.1016/0168-3659(94)90130-9
M3 - Article
SN - 0168-3659
VL - 1994
SP - 143
EP - 155
JO - Journal of controlled release
JF - Journal of controlled release
IS - 29
ER -