Adriamycin loading and release characteristics of albumin-heparin conjugate microspheres

H.F.M. Cremers, R. Verrijk, H.P.J.M. Noteborn, G. Kwon, Y.H. Bae, S.W. Kim, Jan Feijen

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Abstract

Biodegradable ion-exchange microspheres, prepared from a prefabricated conjugate of albumin and heparin were investigated as carriers for adriamycin. The ion-exchange microspheres could be loaded with adriamycin giving payloads up to 33% w/w, depending on the heparin content of the conjugate. In vitro adriamycin release depended on the ionic strength of the release medium. In ion containing media, for instance saline, 90% of the drug was released within 45 min, whereas in non-ionic media, such as distilled water, only 30% was released. Drug release profiles could be modelled by combining ion-exchange kinetics and diffusion controlled drug release models.
Original languageEnglish
Pages (from-to)143-155
JournalJournal of controlled release
Volume1994
Issue number29
DOIs
Publication statusPublished - 1994

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Ion Exchange
Microspheres
Doxorubicin
Heparin
Albumins
Osmolar Concentration
Ions
Water
Pharmaceutical Preparations
Drug Liberation

Cite this

Cremers, H. F. M., Verrijk, R., Noteborn, H. P. J. M., Kwon, G., Bae, Y. H., Kim, S. W., & Feijen, J. (1994). Adriamycin loading and release characteristics of albumin-heparin conjugate microspheres. Journal of controlled release, 1994(29), 143-155. https://doi.org/10.1016/0168-3659(94)90130-9
Cremers, H.F.M. ; Verrijk, R. ; Noteborn, H.P.J.M. ; Kwon, G. ; Bae, Y.H. ; Kim, S.W. ; Feijen, Jan. / Adriamycin loading and release characteristics of albumin-heparin conjugate microspheres. In: Journal of controlled release. 1994 ; Vol. 1994, No. 29. pp. 143-155.
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Adriamycin loading and release characteristics of albumin-heparin conjugate microspheres. / Cremers, H.F.M.; Verrijk, R.; Noteborn, H.P.J.M.; Kwon, G.; Bae, Y.H.; Kim, S.W.; Feijen, Jan.

In: Journal of controlled release, Vol. 1994, No. 29, 1994, p. 143-155.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Adriamycin loading and release characteristics of albumin-heparin conjugate microspheres

AU - Cremers, H.F.M.

AU - Verrijk, R.

AU - Noteborn, H.P.J.M.

AU - Kwon, G.

AU - Bae, Y.H.

AU - Kim, S.W.

AU - Feijen, Jan

PY - 1994

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N2 - Biodegradable ion-exchange microspheres, prepared from a prefabricated conjugate of albumin and heparin were investigated as carriers for adriamycin. The ion-exchange microspheres could be loaded with adriamycin giving payloads up to 33% w/w, depending on the heparin content of the conjugate. In vitro adriamycin release depended on the ionic strength of the release medium. In ion containing media, for instance saline, 90% of the drug was released within 45 min, whereas in non-ionic media, such as distilled water, only 30% was released. Drug release profiles could be modelled by combining ion-exchange kinetics and diffusion controlled drug release models.

AB - Biodegradable ion-exchange microspheres, prepared from a prefabricated conjugate of albumin and heparin were investigated as carriers for adriamycin. The ion-exchange microspheres could be loaded with adriamycin giving payloads up to 33% w/w, depending on the heparin content of the conjugate. In vitro adriamycin release depended on the ionic strength of the release medium. In ion containing media, for instance saline, 90% of the drug was released within 45 min, whereas in non-ionic media, such as distilled water, only 30% was released. Drug release profiles could be modelled by combining ion-exchange kinetics and diffusion controlled drug release models.

U2 - 10.1016/0168-3659(94)90130-9

DO - 10.1016/0168-3659(94)90130-9

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SP - 143

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JF - Journal of controlled release

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