Adsorption of a synthetic heparinoid polyelectrolyte on an ion-exchanging surface

Peter E. Froehling, Adriaan Bantjes, Z. Kolar

    Research output: Contribution to journalArticleAcademic

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    Abstract

    The adsorption of a synthetic heparinoid polyelectrolyte on poly(vinylchloride) previously treated with tridodecylmethylammonium chloride (TDMAC) was studied using radiotracer techniques to provide a more quantitative picture of antithrombogenic surface coatings. 125I-labeled polyelectrolyte was used for overall adsorption measurements. Experiments with 36Cl-labeled TDMAC yielded information on actually adsorbed polyelectrolyte segments in good agreement with existing theory. A large excess of free dangling segments was found. In the presence of NaCl the total adsorption was diminished, although no desorption occurred on treatment of adsorbates with 0.15 M NaCl or blood plasma.
    Original languageEnglish
    Pages (from-to)35-39
    JournalJournal of colloid and interface science
    Volume62
    Issue number1
    DOIs
    Publication statusPublished - 1977

    Fingerprint

    Heparinoids
    Polyelectrolytes
    Ion exchange
    Adsorption
    Adsorbates
    Desorption
    Blood
    Plasmas
    Coatings
    Experiments
    tridodecylmethylammonium

    Keywords

    • IR-68020

    Cite this

    Froehling, Peter E. ; Bantjes, Adriaan ; Kolar, Z. / Adsorption of a synthetic heparinoid polyelectrolyte on an ion-exchanging surface. In: Journal of colloid and interface science. 1977 ; Vol. 62, No. 1. pp. 35-39.
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    abstract = "The adsorption of a synthetic heparinoid polyelectrolyte on poly(vinylchloride) previously treated with tridodecylmethylammonium chloride (TDMAC) was studied using radiotracer techniques to provide a more quantitative picture of antithrombogenic surface coatings. 125I-labeled polyelectrolyte was used for overall adsorption measurements. Experiments with 36Cl-labeled TDMAC yielded information on actually adsorbed polyelectrolyte segments in good agreement with existing theory. A large excess of free dangling segments was found. In the presence of NaCl the total adsorption was diminished, although no desorption occurred on treatment of adsorbates with 0.15 M NaCl or blood plasma.",
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    Adsorption of a synthetic heparinoid polyelectrolyte on an ion-exchanging surface. / Froehling, Peter E.; Bantjes, Adriaan; Kolar, Z.

    In: Journal of colloid and interface science, Vol. 62, No. 1, 1977, p. 35-39.

    Research output: Contribution to journalArticleAcademic

    TY - JOUR

    T1 - Adsorption of a synthetic heparinoid polyelectrolyte on an ion-exchanging surface

    AU - Froehling, Peter E.

    AU - Bantjes, Adriaan

    AU - Kolar, Z.

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    N2 - The adsorption of a synthetic heparinoid polyelectrolyte on poly(vinylchloride) previously treated with tridodecylmethylammonium chloride (TDMAC) was studied using radiotracer techniques to provide a more quantitative picture of antithrombogenic surface coatings. 125I-labeled polyelectrolyte was used for overall adsorption measurements. Experiments with 36Cl-labeled TDMAC yielded information on actually adsorbed polyelectrolyte segments in good agreement with existing theory. A large excess of free dangling segments was found. In the presence of NaCl the total adsorption was diminished, although no desorption occurred on treatment of adsorbates with 0.15 M NaCl or blood plasma.

    AB - The adsorption of a synthetic heparinoid polyelectrolyte on poly(vinylchloride) previously treated with tridodecylmethylammonium chloride (TDMAC) was studied using radiotracer techniques to provide a more quantitative picture of antithrombogenic surface coatings. 125I-labeled polyelectrolyte was used for overall adsorption measurements. Experiments with 36Cl-labeled TDMAC yielded information on actually adsorbed polyelectrolyte segments in good agreement with existing theory. A large excess of free dangling segments was found. In the presence of NaCl the total adsorption was diminished, although no desorption occurred on treatment of adsorbates with 0.15 M NaCl or blood plasma.

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