The adsorption of a synthetic heparinoid polyelectrolyte on poly(vinylchloride) previously treated with tridodecylmethylammonium chloride (TDMAC) was studied using radiotracer techniques to provide a more quantitative picture of antithrombogenic surface coatings. 125I-labeled polyelectrolyte was used for overall adsorption measurements. Experiments with 36Cl-labeled TDMAC yielded information on actually adsorbed polyelectrolyte segments in good agreement with existing theory. A large excess of free dangling segments was found. In the presence of NaCl the total adsorption was diminished, although no desorption occurred on treatment of adsorbates with 0.15 M NaCl or blood plasma.
Froehling, P. E., Bantjes, A., & Kolar, Z. (1977). Adsorption of a synthetic heparinoid polyelectrolyte on an ion-exchanging surface. Journal of colloid and interface science, 62(1), 35-39. https://doi.org/10.1016/0021-9797(77)90062-5