Adsorption of a synthetic heparinoid polyelectrolyte on an ion-exchanging surface

Peter E. Froehling; Adriaan Bantjes; Z. Kolar

doi:10.1016/0021-9797(77)90062-5

Adsorption of a synthetic heparinoid polyelectrolyte on an ion-exchanging surface

Peter E. Froehling, Adriaan Bantjes, Z. Kolar

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Abstract

The adsorption of a synthetic heparinoid polyelectrolyte on poly(vinylchloride) previously treated with tridodecylmethylammonium chloride (TDMAC) was studied using radiotracer techniques to provide a more quantitative picture of antithrombogenic surface coatings. 125I-labeled polyelectrolyte was used for overall adsorption measurements. Experiments with 36Cl-labeled TDMAC yielded information on actually adsorbed polyelectrolyte segments in good agreement with existing theory. A large excess of free dangling segments was found. In the presence of NaCl the total adsorption was diminished, although no desorption occurred on treatment of adsorbates with 0.15 M NaCl or blood plasma.

Original language	English
Pages (from-to)	35-39
Journal	Journal of colloid and interface science
Volume	62
Issue number	1
DOIs	https://doi.org/10.1016/0021-9797(77)90062-5
Publication status	Published - 1977

Keywords

IR-68020

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10.1016/0021-9797(77)90062-5

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title = "Adsorption of a synthetic heparinoid polyelectrolyte on an ion-exchanging surface",

abstract = "The adsorption of a synthetic heparinoid polyelectrolyte on poly(vinylchloride) previously treated with tridodecylmethylammonium chloride (TDMAC) was studied using radiotracer techniques to provide a more quantitative picture of antithrombogenic surface coatings. 125I-labeled polyelectrolyte was used for overall adsorption measurements. Experiments with 36Cl-labeled TDMAC yielded information on actually adsorbed polyelectrolyte segments in good agreement with existing theory. A large excess of free dangling segments was found. In the presence of NaCl the total adsorption was diminished, although no desorption occurred on treatment of adsorbates with 0.15 M NaCl or blood plasma.",

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T1 - Adsorption of a synthetic heparinoid polyelectrolyte on an ion-exchanging surface

AU - Froehling, Peter E.

AU - Bantjes, Adriaan

AU - Kolar, Z.

PY - 1977

Y1 - 1977

N2 - The adsorption of a synthetic heparinoid polyelectrolyte on poly(vinylchloride) previously treated with tridodecylmethylammonium chloride (TDMAC) was studied using radiotracer techniques to provide a more quantitative picture of antithrombogenic surface coatings. 125I-labeled polyelectrolyte was used for overall adsorption measurements. Experiments with 36Cl-labeled TDMAC yielded information on actually adsorbed polyelectrolyte segments in good agreement with existing theory. A large excess of free dangling segments was found. In the presence of NaCl the total adsorption was diminished, although no desorption occurred on treatment of adsorbates with 0.15 M NaCl or blood plasma.

AB - The adsorption of a synthetic heparinoid polyelectrolyte on poly(vinylchloride) previously treated with tridodecylmethylammonium chloride (TDMAC) was studied using radiotracer techniques to provide a more quantitative picture of antithrombogenic surface coatings. 125I-labeled polyelectrolyte was used for overall adsorption measurements. Experiments with 36Cl-labeled TDMAC yielded information on actually adsorbed polyelectrolyte segments in good agreement with existing theory. A large excess of free dangling segments was found. In the presence of NaCl the total adsorption was diminished, although no desorption occurred on treatment of adsorbates with 0.15 M NaCl or blood plasma.

KW - IR-68020

U2 - 10.1016/0021-9797(77)90062-5

DO - 10.1016/0021-9797(77)90062-5

M3 - Article

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VL - 62

SP - 35

EP - 39

JO - Journal of colloid and interface science

JF - Journal of colloid and interface science

IS - 1

ER -

Adsorption of a synthetic heparinoid polyelectrolyte on an ion-exchanging surface

Abstract

Keywords

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