Adsorption of plasma proteins and adhesion of cells onto polymer surfaces

T. Beugeling*, A. Poot, P. B. van Wachem, E. Brinkman, W. G. van Aken, A. Bantjes

*Corresponding author for this work

    Research output: Contribution to conferencePaperpeer-review


    A two step enzyme-immunoassay has been used to study protein adsorption to material surfaces from complex mixtures like blood plasma and a serum-containing culture medium for cells. Some results with respect to the competitive adsorption of plasma proteins to polymers and glass are given. Fibrinogen shows a high adsorption to polyester from plasma while high molecular weight kininogen (HMWK) shows a low adsorption to this polymer. On the contrary, glass exhibits a high adsorption of HMWK and a low adsorption of fibrinogen. Polymers which show a fibronectin adsorption from the culture medium promote the adhesion of human endothelial cells. Such polymers presumably permit the cells to deposit their own fibronectin upon the material surface and this in turn will lead to an overgrowth of cells.

    Original languageEnglish
    Pages36. 1-36. 8
    Publication statusPublished - 1986


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