Aerobic activity in the healthy elderly is associated with larger plasticity in memory related brain structures and lower systemic inflammation

Jan Willem Thielen, Christian Kärgel, Bernhard W. Müller, Ina Rasche, Just Genius, Boudewijn Bus, Stefan Maderwald, David G. Norris, Jens Wiltfang, Indira Tendolkar

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Abstract

Cognitive abilities decline over the time course of our life, a process, which may be mediated by brain atrophy and enhanced inflammatory processes. Lifestyle factors, such as regular physical activities have been shown to counteract those noxious processes and are assumed to delay or possibly even prevent pathological states, such as dementing disorders. Whereas the impact of lifestyle and immunological factors and their interactions on cognitive aging have been frequently studied, their effects on neural parameters as brain activation and functional connectivity are less well studied. Therefore, we investigated 32 healthy elderly individuals (60.4 ± 5.0 SD; range 52-71 years) with low or high level of self-reported aerobic physical activity at the time of testing. A higher compared to a lower level in aerobic physical activity was associated with an increased encoding related functional connectivity in an episodic memory network comprising mPFC, thalamus, hippocampus precuneus, and insula. Moreover, encoding related functional connectivity of this network was associated with decreased systemic inflammation, as measured by systemic levels of interleukin 6.

Original languageEnglish
Article number319
JournalFrontiers in Aging Neuroscience
Volume8
Issue numberDEC
DOIs
Publication statusPublished - 2016
Externally publishedYes

Fingerprint

Exercise
Inflammation
Life Style
Brain
Parietal Lobe
Aptitude
Episodic Memory
Immunologic Factors
Thalamus
Atrophy
Interleukin-6
Hippocampus
Cognitive Dysfunction
Cognitive Aging

Keywords

  • Elderly
  • FMRI
  • Functional connectivity
  • Inflammation
  • Interleukin-6
  • Memory
  • Physical activity

Cite this

Thielen, Jan Willem ; Kärgel, Christian ; Müller, Bernhard W. ; Rasche, Ina ; Genius, Just ; Bus, Boudewijn ; Maderwald, Stefan ; Norris, David G. ; Wiltfang, Jens ; Tendolkar, Indira. / Aerobic activity in the healthy elderly is associated with larger plasticity in memory related brain structures and lower systemic inflammation. In: Frontiers in Aging Neuroscience. 2016 ; Vol. 8, No. DEC.
@article{bb0ff013595b4100a3ab627125eaeae8,
title = "Aerobic activity in the healthy elderly is associated with larger plasticity in memory related brain structures and lower systemic inflammation",
abstract = "Cognitive abilities decline over the time course of our life, a process, which may be mediated by brain atrophy and enhanced inflammatory processes. Lifestyle factors, such as regular physical activities have been shown to counteract those noxious processes and are assumed to delay or possibly even prevent pathological states, such as dementing disorders. Whereas the impact of lifestyle and immunological factors and their interactions on cognitive aging have been frequently studied, their effects on neural parameters as brain activation and functional connectivity are less well studied. Therefore, we investigated 32 healthy elderly individuals (60.4 ± 5.0 SD; range 52-71 years) with low or high level of self-reported aerobic physical activity at the time of testing. A higher compared to a lower level in aerobic physical activity was associated with an increased encoding related functional connectivity in an episodic memory network comprising mPFC, thalamus, hippocampus precuneus, and insula. Moreover, encoding related functional connectivity of this network was associated with decreased systemic inflammation, as measured by systemic levels of interleukin 6.",
keywords = "Elderly, FMRI, Functional connectivity, Inflammation, Interleukin-6, Memory, Physical activity",
author = "Thielen, {Jan Willem} and Christian K{\"a}rgel and M{\"u}ller, {Bernhard W.} and Ina Rasche and Just Genius and Boudewijn Bus and Stefan Maderwald and Norris, {David G.} and Jens Wiltfang and Indira Tendolkar",
year = "2016",
doi = "10.3389/fnagi.2016.00319",
language = "English",
volume = "8",
journal = "Frontiers in Aging Neuroscience",
issn = "1663-4365",
publisher = "Frontiers Media S.A.",
number = "DEC",

}

Aerobic activity in the healthy elderly is associated with larger plasticity in memory related brain structures and lower systemic inflammation. / Thielen, Jan Willem; Kärgel, Christian; Müller, Bernhard W.; Rasche, Ina; Genius, Just; Bus, Boudewijn; Maderwald, Stefan; Norris, David G.; Wiltfang, Jens; Tendolkar, Indira.

In: Frontiers in Aging Neuroscience, Vol. 8, No. DEC, 319, 2016.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Aerobic activity in the healthy elderly is associated with larger plasticity in memory related brain structures and lower systemic inflammation

AU - Thielen, Jan Willem

AU - Kärgel, Christian

AU - Müller, Bernhard W.

AU - Rasche, Ina

AU - Genius, Just

AU - Bus, Boudewijn

AU - Maderwald, Stefan

AU - Norris, David G.

AU - Wiltfang, Jens

AU - Tendolkar, Indira

PY - 2016

Y1 - 2016

N2 - Cognitive abilities decline over the time course of our life, a process, which may be mediated by brain atrophy and enhanced inflammatory processes. Lifestyle factors, such as regular physical activities have been shown to counteract those noxious processes and are assumed to delay or possibly even prevent pathological states, such as dementing disorders. Whereas the impact of lifestyle and immunological factors and their interactions on cognitive aging have been frequently studied, their effects on neural parameters as brain activation and functional connectivity are less well studied. Therefore, we investigated 32 healthy elderly individuals (60.4 ± 5.0 SD; range 52-71 years) with low or high level of self-reported aerobic physical activity at the time of testing. A higher compared to a lower level in aerobic physical activity was associated with an increased encoding related functional connectivity in an episodic memory network comprising mPFC, thalamus, hippocampus precuneus, and insula. Moreover, encoding related functional connectivity of this network was associated with decreased systemic inflammation, as measured by systemic levels of interleukin 6.

AB - Cognitive abilities decline over the time course of our life, a process, which may be mediated by brain atrophy and enhanced inflammatory processes. Lifestyle factors, such as regular physical activities have been shown to counteract those noxious processes and are assumed to delay or possibly even prevent pathological states, such as dementing disorders. Whereas the impact of lifestyle and immunological factors and their interactions on cognitive aging have been frequently studied, their effects on neural parameters as brain activation and functional connectivity are less well studied. Therefore, we investigated 32 healthy elderly individuals (60.4 ± 5.0 SD; range 52-71 years) with low or high level of self-reported aerobic physical activity at the time of testing. A higher compared to a lower level in aerobic physical activity was associated with an increased encoding related functional connectivity in an episodic memory network comprising mPFC, thalamus, hippocampus precuneus, and insula. Moreover, encoding related functional connectivity of this network was associated with decreased systemic inflammation, as measured by systemic levels of interleukin 6.

KW - Elderly

KW - FMRI

KW - Functional connectivity

KW - Inflammation

KW - Interleukin-6

KW - Memory

KW - Physical activity

UR - http://www.scopus.com/inward/record.url?scp=85009488978&partnerID=8YFLogxK

U2 - 10.3389/fnagi.2016.00319

DO - 10.3389/fnagi.2016.00319

M3 - Article

VL - 8

JO - Frontiers in Aging Neuroscience

JF - Frontiers in Aging Neuroscience

SN - 1663-4365

IS - DEC

M1 - 319

ER -