Age-related changes in tyrosine hydroxylase-immunoreactive neurons in rat mesencephalon

D.E. Itzev, K.G. Usunoff, Enrico Marani, W.A. Ovtscharoff

    Research output: Contribution to journalArticleAcademicpeer-review


    The aim of the present study was to compare the morphological pattern and the quantitative parameters of tyrosine hydroxylase- (TH)-containing neurons of the ventral tegmental area (VTA) and substantia nigra (SN) in young (3-months old) and senescent (24-28 months old) male Wistar rats. The reaction product is homogeneous and fills the entire perikaryon and often extends in the dendrites and axons of the neurons. The borders of VTA and SN are sharply outlined. In VTA the TH-positive neurons are regularly distributed, while in SN they are concentrated in pars compacta and in pars lateralis.
    Original languageUndefined
    Pages (from-to)337-342
    Number of pages6
    JournalProceedings of the Bulgarian Academy of Sciences
    Issue number2/3
    Publication statusPublished - 8 Jan 2006
    EventComptes rendus de l'Académie bulgare des Sciences - Sofia, Bulgaria
    Duration: 8 Jan 20068 Jan 2006


    • EWI-6971
    • cross-sectional area
    • optical density
    • substantia nigra
    • morphometry
    • METIS-238188
    • ventral tegmental area

    Cite this