Age-related changes in tyrosine hydroxylase-immunoreactive neurons in rat mesencephalon

D.E. Itzev; K.G. Usunoff; Enrico Marani; W.A. Ovtscharoff

Age-related changes in tyrosine hydroxylase-immunoreactive neurons in rat mesencephalon

D.E. Itzev, K.G. Usunoff, Enrico Marani, W.A. Ovtscharoff

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The aim of the present study was to compare the morphological pattern and the quantitative parameters of tyrosine hydroxylase- (TH)-containing neurons of the ventral tegmental area (VTA) and substantia nigra (SN) in young (3-months old) and senescent (24-28 months old) male Wistar rats. The reaction product is homogeneous and fills the entire perikaryon and often extends in the dendrites and axons of the neurons. The borders of VTA and SN are sharply outlined. In VTA the TH-positive neurons are regularly distributed, while in SN they are concentrated in pars compacta and in pars lateralis.

Original language	Undefined
Pages (from-to)	337-342
Number of pages	6
Journal	Proceedings of the Bulgarian Academy of Sciences
Volume	59
Issue number	2/3
Publication status	Published - 8 Jan 2006
Event	Comptes rendus de l'Académie bulgare des Sciences - Sofia, Bulgaria Duration: 8 Jan 2006 → 8 Jan 2006

Keywords

EWI-6971
cross-sectional area
optical density
substantia nigra
morphometry
METIS-238188
ventral tegmental area

Cite this

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title = "Age-related changes in tyrosine hydroxylase-immunoreactive neurons in rat mesencephalon",

abstract = "The aim of the present study was to compare the morphological pattern and the quantitative parameters of tyrosine hydroxylase- (TH)-containing neurons of the ventral tegmental area (VTA) and substantia nigra (SN) in young (3-months old) and senescent (24-28 months old) male Wistar rats. The reaction product is homogeneous and fills the entire perikaryon and often extends in the dendrites and axons of the neurons. The borders of VTA and SN are sharply outlined. In VTA the TH-positive neurons are regularly distributed, while in SN they are concentrated in pars compacta and in pars lateralis.",

keywords = "EWI-6971, cross-sectional area, optical density, substantia nigra, morphometry, METIS-238188, ventral tegmental area",

author = "D.E. Itzev and K.G. Usunoff and Enrico Marani and W.A. Ovtscharoff",

year = "2006",

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volume = "59",

pages = "337--342",

journal = "Proceedings of the Bulgarian Academy of Sciences",

issn = "1310-1331",

publisher = "Bulgarian Academy of Sciences",

number = "2/3",

note = "Comptes rendus de l'Acad{\'e}mie bulgare des Sciences ; Conference date: 08-01-2006 Through 08-01-2006",

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TY - JOUR

T1 - Age-related changes in tyrosine hydroxylase-immunoreactive neurons in rat mesencephalon

AU - Itzev, D.E.

AU - Usunoff, K.G.

AU - Marani, Enrico

AU - Ovtscharoff, W.A.

PY - 2006/1/8

Y1 - 2006/1/8

N2 - The aim of the present study was to compare the morphological pattern and the quantitative parameters of tyrosine hydroxylase- (TH)-containing neurons of the ventral tegmental area (VTA) and substantia nigra (SN) in young (3-months old) and senescent (24-28 months old) male Wistar rats. The reaction product is homogeneous and fills the entire perikaryon and often extends in the dendrites and axons of the neurons. The borders of VTA and SN are sharply outlined. In VTA the TH-positive neurons are regularly distributed, while in SN they are concentrated in pars compacta and in pars lateralis.

AB - The aim of the present study was to compare the morphological pattern and the quantitative parameters of tyrosine hydroxylase- (TH)-containing neurons of the ventral tegmental area (VTA) and substantia nigra (SN) in young (3-months old) and senescent (24-28 months old) male Wistar rats. The reaction product is homogeneous and fills the entire perikaryon and often extends in the dendrites and axons of the neurons. The borders of VTA and SN are sharply outlined. In VTA the TH-positive neurons are regularly distributed, while in SN they are concentrated in pars compacta and in pars lateralis.

KW - EWI-6971

KW - cross-sectional area

KW - optical density

KW - substantia nigra

KW - morphometry

KW - METIS-238188

KW - ventral tegmental area

M3 - Article

SN - 1310-1331

VL - 59

SP - 337

EP - 342

JO - Proceedings of the Bulgarian Academy of Sciences

JF - Proceedings of the Bulgarian Academy of Sciences

IS - 2/3

T2 - Comptes rendus de l'Académie bulgare des Sciences

Y2 - 8 January 2006 through 8 January 2006

ER -