Age-related differences in myeloarchitecture measured at 7 T

Andrew J. Carradus; Olivier Mougin; Benjamin A.E. Hunt; Prejaas K. Tewarie; Nicolas Geades; Peter G. Morris; Matthew J. Brookes; Penny A. Gowland; Christopher R. Madan

doi:10.1016/j.neurobiolaging.2020.08.009

Age-related differences in myeloarchitecture measured at 7 T

Andrew J. Carradus, Olivier Mougin, Benjamin A.E. Hunt, Prejaas K. Tewarie, Nicolas Geades, Peter G. Morris, Matthew J. Brookes, Penny A. Gowland, Christopher R. Madan^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

We have used the magnetisation transfer (MT) MRI measure as a primary measure of myelination in both the gray matter (GM) of the 78 cortical automated anatomical labeling (AAL) regions of the brain, and the underlying white matter in each region, in a cohort of healthy adults (aged 19–62 year old). The results revealed a significant quadratic trend in myelination with age, with average global myelination peaking at 42.9 year old in gray matter, and at 41.7 year old in white matter. We also explored the possibility of using the Nuclear Overhauser Enhancement (NOE) effect, which is acquired in a similar method to MT, as an additional measure of myelination. We found that the MT and NOE signals were strongly correlated in the brain and that the NOE effects displayed similar (albeit weaker) parabolic trends with age. We also investigated differences in cortical thickness with age, and confirmed a previous result of a linear decline of 4.5 ± 1.2 μm/y.

Original language	English
Pages (from-to)	246-254
Number of pages	9
Journal	Neurobiology of aging
Volume	96
DOIs	https://doi.org/10.1016/j.neurobiolaging.2020.08.009
Publication status	Published - Dec 2020
Externally published	Yes

Keywords

7 tesla
Aging
Brain structure
Gray matter
MT
Myelin

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10.1016/j.neurobiolaging.2020.08.009

Carradus-2020-Age-related-differences-in-myeloarcAccepted author version, 1.02 MBLicence: CC BY-NC-ND

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@article{db847d1b3b324a0eb2217524996c1f10,

title = "Age-related differences in myeloarchitecture measured at 7 T",

abstract = "We have used the magnetisation transfer (MT) MRI measure as a primary measure of myelination in both the gray matter (GM) of the 78 cortical automated anatomical labeling (AAL) regions of the brain, and the underlying white matter in each region, in a cohort of healthy adults (aged 19–62 year old). The results revealed a significant quadratic trend in myelination with age, with average global myelination peaking at 42.9 year old in gray matter, and at 41.7 year old in white matter. We also explored the possibility of using the Nuclear Overhauser Enhancement (NOE) effect, which is acquired in a similar method to MT, as an additional measure of myelination. We found that the MT and NOE signals were strongly correlated in the brain and that the NOE effects displayed similar (albeit weaker) parabolic trends with age. We also investigated differences in cortical thickness with age, and confirmed a previous result of a linear decline of 4.5 ± 1.2 μm/y.",

keywords = "7 tesla, Aging, Brain structure, Gray matter, MT, Myelin",

author = "Carradus, {Andrew J.} and Olivier Mougin and Hunt, {Benjamin A.E.} and Tewarie, {Prejaas K.} and Nicolas Geades and Morris, {Peter G.} and Brookes, {Matthew J.} and Gowland, {Penny A.} and Madan, {Christopher R.}",

note = "Funding Information: Andrew Carradus holds a studentship with the Haydn Green Foundation. Data collection was funded by Medical Research Council (MRC) New Investigator Research Grant MR/M006301/1, MRC Partnership Grant MR/K005464/1, and MRC Doctoral Training Grant MR/K501086/1. Funding Information: Andrew Carradus holds a studentship with the Haydn Green Foundation. Data collection was funded by Medical Research Council (MRC) New Investigator Research Grant MR/M006301/1, MRC Partnership Grant MR/K005464/1, and MRC Doctoral Training Grant MR/K501086/1. Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2020",

month = dec,

doi = "10.1016/j.neurobiolaging.2020.08.009",

language = "English",

volume = "96",

pages = "246--254",

journal = "Neurobiology of aging",

issn = "0197-4580",

publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Age-related differences in myeloarchitecture measured at 7 T

AU - Carradus, Andrew J.

AU - Mougin, Olivier

AU - Hunt, Benjamin A.E.

AU - Tewarie, Prejaas K.

AU - Geades, Nicolas

AU - Morris, Peter G.

AU - Brookes, Matthew J.

AU - Gowland, Penny A.

AU - Madan, Christopher R.

N1 - Funding Information: Andrew Carradus holds a studentship with the Haydn Green Foundation. Data collection was funded by Medical Research Council (MRC) New Investigator Research Grant MR/M006301/1, MRC Partnership Grant MR/K005464/1, and MRC Doctoral Training Grant MR/K501086/1. Funding Information: Andrew Carradus holds a studentship with the Haydn Green Foundation. Data collection was funded by Medical Research Council (MRC) New Investigator Research Grant MR/M006301/1, MRC Partnership Grant MR/K005464/1, and MRC Doctoral Training Grant MR/K501086/1. Publisher Copyright: © 2020 Elsevier Inc.

PY - 2020/12

Y1 - 2020/12

N2 - We have used the magnetisation transfer (MT) MRI measure as a primary measure of myelination in both the gray matter (GM) of the 78 cortical automated anatomical labeling (AAL) regions of the brain, and the underlying white matter in each region, in a cohort of healthy adults (aged 19–62 year old). The results revealed a significant quadratic trend in myelination with age, with average global myelination peaking at 42.9 year old in gray matter, and at 41.7 year old in white matter. We also explored the possibility of using the Nuclear Overhauser Enhancement (NOE) effect, which is acquired in a similar method to MT, as an additional measure of myelination. We found that the MT and NOE signals were strongly correlated in the brain and that the NOE effects displayed similar (albeit weaker) parabolic trends with age. We also investigated differences in cortical thickness with age, and confirmed a previous result of a linear decline of 4.5 ± 1.2 μm/y.

AB - We have used the magnetisation transfer (MT) MRI measure as a primary measure of myelination in both the gray matter (GM) of the 78 cortical automated anatomical labeling (AAL) regions of the brain, and the underlying white matter in each region, in a cohort of healthy adults (aged 19–62 year old). The results revealed a significant quadratic trend in myelination with age, with average global myelination peaking at 42.9 year old in gray matter, and at 41.7 year old in white matter. We also explored the possibility of using the Nuclear Overhauser Enhancement (NOE) effect, which is acquired in a similar method to MT, as an additional measure of myelination. We found that the MT and NOE signals were strongly correlated in the brain and that the NOE effects displayed similar (albeit weaker) parabolic trends with age. We also investigated differences in cortical thickness with age, and confirmed a previous result of a linear decline of 4.5 ± 1.2 μm/y.

KW - 7 tesla

KW - Aging

KW - Brain structure

KW - Gray matter

KW - MT

KW - Myelin

UR - http://www.scopus.com/inward/record.url?scp=85092266007&partnerID=8YFLogxK

U2 - 10.1016/j.neurobiolaging.2020.08.009

DO - 10.1016/j.neurobiolaging.2020.08.009

M3 - Article

C2 - 33049517

AN - SCOPUS:85092266007

SN - 0197-4580

VL - 96

SP - 246

EP - 254

JO - Neurobiology of aging

JF - Neurobiology of aging

ER -

Age-related differences in myeloarchitecture measured at 7 T

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Keywords

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