Age-specific differences in the treatment of cervical cander in the east and the south of the Netherlands 1989-2004

Maaike A. van der Aa, Sabine Siesling, Lonneke V. v.d. Poll-Franse, Eltjo M. Schutter, Marnix L. Lybeert, Jan Willem W. Coebergh

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Abstract

Objective: This study aims to describe trends and variation in treatment and survival of cervical cancer in two regions in The Netherlands and to relate this to adherence to the treatment recommendations.Study design: Patient characteristics, tumour characteristics, treatment and follow-up data were collected for 1954 cervical cancer cases diagnosed in the period 1989–2004.Results: In FIGO stages IB-IIA 93% of patients were treated according to the recommendations of The Netherlands Working Group Gynaecologic Oncology. Older patients received radiotherapymore often than younger patients: 48% (95%CI 40–57) of patients older than 70 compared to 15% (95%CI 10–20) of patients aged 50–69 and 5% (95%CI 3–7) of patients aged 50 or younger (p < 0.05). In FIGO stages IIB-IVA 76% of patients were treated according to the recommendations of the Working Group. Chemoradiation was given to older patients less often than to younger patients: 2% (95%CI 0.5–5) versus 23% (95%CI 16–29). A decreased risk of death was found for patients receiving chemoradiation (RER 0.6, 95%CI 0.3–0.9) compared to those receiving “radiotherapy only”.Conclusion: Far from being always followed, the treatment recommendations were better implemented for treatment of patients with FIGO IB-IIA. Elderly patients received different treatment compared to younger patients in this study and showed an independent increased risk of death in the lower stages, which confirms that the need becomes stronger for paying attention to treatment of elderly patients.
Original languageEnglish
Pages (from-to)78-82
Number of pages5
JournalEuropean journal of obstetrics and gynaecology and reproductive biology
Volume147
Issue number1
DOIs
Publication statusPublished - 2009

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Netherlands
Therapeutics
Uterine Cervical Neoplasms
Radiotherapy

Keywords

  • METIS-260338
  • IR-77355

Cite this

van der Aa, Maaike A. ; Siesling, Sabine ; v.d. Poll-Franse, Lonneke V. ; Schutter, Eltjo M. ; Lybeert, Marnix L. ; Coebergh, Jan Willem W. / Age-specific differences in the treatment of cervical cander in the east and the south of the Netherlands 1989-2004. In: European journal of obstetrics and gynaecology and reproductive biology. 2009 ; Vol. 147, No. 1. pp. 78-82.
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title = "Age-specific differences in the treatment of cervical cander in the east and the south of the Netherlands 1989-2004",
abstract = "Objective: This study aims to describe trends and variation in treatment and survival of cervical cancer in two regions in The Netherlands and to relate this to adherence to the treatment recommendations.Study design: Patient characteristics, tumour characteristics, treatment and follow-up data were collected for 1954 cervical cancer cases diagnosed in the period 1989–2004.Results: In FIGO stages IB-IIA 93{\%} of patients were treated according to the recommendations of The Netherlands Working Group Gynaecologic Oncology. Older patients received radiotherapymore often than younger patients: 48{\%} (95{\%}CI 40–57) of patients older than 70 compared to 15{\%} (95{\%}CI 10–20) of patients aged 50–69 and 5{\%} (95{\%}CI 3–7) of patients aged 50 or younger (p < 0.05). In FIGO stages IIB-IVA 76{\%} of patients were treated according to the recommendations of the Working Group. Chemoradiation was given to older patients less often than to younger patients: 2{\%} (95{\%}CI 0.5–5) versus 23{\%} (95{\%}CI 16–29). A decreased risk of death was found for patients receiving chemoradiation (RER 0.6, 95{\%}CI 0.3–0.9) compared to those receiving “radiotherapy only”.Conclusion: Far from being always followed, the treatment recommendations were better implemented for treatment of patients with FIGO IB-IIA. Elderly patients received different treatment compared to younger patients in this study and showed an independent increased risk of death in the lower stages, which confirms that the need becomes stronger for paying attention to treatment of elderly patients.",
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Age-specific differences in the treatment of cervical cander in the east and the south of the Netherlands 1989-2004. / van der Aa, Maaike A.; Siesling, Sabine ; v.d. Poll-Franse, Lonneke V.; Schutter, Eltjo M.; Lybeert, Marnix L.; Coebergh, Jan Willem W.

In: European journal of obstetrics and gynaecology and reproductive biology, Vol. 147, No. 1, 2009, p. 78-82.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Age-specific differences in the treatment of cervical cander in the east and the south of the Netherlands 1989-2004

AU - van der Aa, Maaike A.

AU - Siesling, Sabine

AU - v.d. Poll-Franse, Lonneke V.

AU - Schutter, Eltjo M.

AU - Lybeert, Marnix L.

AU - Coebergh, Jan Willem W.

PY - 2009

Y1 - 2009

N2 - Objective: This study aims to describe trends and variation in treatment and survival of cervical cancer in two regions in The Netherlands and to relate this to adherence to the treatment recommendations.Study design: Patient characteristics, tumour characteristics, treatment and follow-up data were collected for 1954 cervical cancer cases diagnosed in the period 1989–2004.Results: In FIGO stages IB-IIA 93% of patients were treated according to the recommendations of The Netherlands Working Group Gynaecologic Oncology. Older patients received radiotherapymore often than younger patients: 48% (95%CI 40–57) of patients older than 70 compared to 15% (95%CI 10–20) of patients aged 50–69 and 5% (95%CI 3–7) of patients aged 50 or younger (p < 0.05). In FIGO stages IIB-IVA 76% of patients were treated according to the recommendations of the Working Group. Chemoradiation was given to older patients less often than to younger patients: 2% (95%CI 0.5–5) versus 23% (95%CI 16–29). A decreased risk of death was found for patients receiving chemoradiation (RER 0.6, 95%CI 0.3–0.9) compared to those receiving “radiotherapy only”.Conclusion: Far from being always followed, the treatment recommendations were better implemented for treatment of patients with FIGO IB-IIA. Elderly patients received different treatment compared to younger patients in this study and showed an independent increased risk of death in the lower stages, which confirms that the need becomes stronger for paying attention to treatment of elderly patients.

AB - Objective: This study aims to describe trends and variation in treatment and survival of cervical cancer in two regions in The Netherlands and to relate this to adherence to the treatment recommendations.Study design: Patient characteristics, tumour characteristics, treatment and follow-up data were collected for 1954 cervical cancer cases diagnosed in the period 1989–2004.Results: In FIGO stages IB-IIA 93% of patients were treated according to the recommendations of The Netherlands Working Group Gynaecologic Oncology. Older patients received radiotherapymore often than younger patients: 48% (95%CI 40–57) of patients older than 70 compared to 15% (95%CI 10–20) of patients aged 50–69 and 5% (95%CI 3–7) of patients aged 50 or younger (p < 0.05). In FIGO stages IIB-IVA 76% of patients were treated according to the recommendations of the Working Group. Chemoradiation was given to older patients less often than to younger patients: 2% (95%CI 0.5–5) versus 23% (95%CI 16–29). A decreased risk of death was found for patients receiving chemoradiation (RER 0.6, 95%CI 0.3–0.9) compared to those receiving “radiotherapy only”.Conclusion: Far from being always followed, the treatment recommendations were better implemented for treatment of patients with FIGO IB-IIA. Elderly patients received different treatment compared to younger patients in this study and showed an independent increased risk of death in the lower stages, which confirms that the need becomes stronger for paying attention to treatment of elderly patients.

KW - METIS-260338

KW - IR-77355

U2 - 10.1016/j.ejogrb.2009.07.006

DO - 10.1016/j.ejogrb.2009.07.006

M3 - Article

VL - 147

SP - 78

EP - 82

JO - European journal of obstetrics and gynaecology and reproductive biology

JF - European journal of obstetrics and gynaecology and reproductive biology

SN - 0301-2115

IS - 1

ER -