Al2O3 microring resonators for the detection of a cancer biomarker in undiluted urine

M. De Goede, M. Dijkstra, R. Obregón, J. Ramón-azcón, E. Martínez, L. Padilla, F. Mitjans, S. M. Garcia-blanco

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Abstract

Concentrations down to 3 nM of the rhS100A4 protein, associated with human tumor development, have been detected in undiluted urine using an integrated sensor based on microring resonators in the emerging Al2O3 photonic platform. The fabricated microrings were designed for operation in the C-band (λ = 1565 nm) and exhibited a high-quality factor in air of 3.2 × 105. The bulk refractive index sensitivity of the devices was ~100 nm/RIU (for TM polarization) with a limit of detection of ~10−6 RIU. A surface functionalization protocol was developed to allow for the selective binding of the monoclonal antibodies designed to capture the target biomarker to the surface of the Al2O3 microrings. The detection of rhS100A4 proteins at clinically relevant concentrations in urine is a big milestone towards the use of biosensors for the screening and early diagnosis of different cancers. Biosensors based on this microring technology can lead to portable, multiplexed and easy-to-use point of care devices.
Original languageEnglish
Pages (from-to)18508-18521
JournalOptics express
Volume27
Issue number13
DOIs
Publication statusPublished - 18 Jun 2019

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urine
biomarkers
bioinstrumentation
cancer
resonators
proteins
C band
antibodies
Q factors
emerging
tumors
screening
platforms
photonics
refractivity
sensitivity
sensors
air
polarization

Cite this

De Goede, M. ; Dijkstra, M. ; Obregón, R. ; Ramón-azcón, J. ; Martínez, E. ; Padilla, L. ; Mitjans, F. ; Garcia-blanco, S. M. / Al2O3 microring resonators for the detection of a cancer biomarker in undiluted urine. In: Optics express. 2019 ; Vol. 27, No. 13. pp. 18508-18521.
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abstract = "Concentrations down to 3 nM of the rhS100A4 protein, associated with human tumor development, have been detected in undiluted urine using an integrated sensor based on microring resonators in the emerging Al2O3 photonic platform. The fabricated microrings were designed for operation in the C-band (λ = 1565 nm) and exhibited a high-quality factor in air of 3.2 × 105. The bulk refractive index sensitivity of the devices was ~100 nm/RIU (for TM polarization) with a limit of detection of ~10−6 RIU. A surface functionalization protocol was developed to allow for the selective binding of the monoclonal antibodies designed to capture the target biomarker to the surface of the Al2O3 microrings. The detection of rhS100A4 proteins at clinically relevant concentrations in urine is a big milestone towards the use of biosensors for the screening and early diagnosis of different cancers. Biosensors based on this microring technology can lead to portable, multiplexed and easy-to-use point of care devices.",
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Al2O3 microring resonators for the detection of a cancer biomarker in undiluted urine. / De Goede, M.; Dijkstra, M.; Obregón, R.; Ramón-azcón, J.; Martínez, E.; Padilla, L.; Mitjans, F.; Garcia-blanco, S. M.

In: Optics express, Vol. 27, No. 13, 18.06.2019, p. 18508-18521.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - Al2O3 microring resonators for the detection of a cancer biomarker in undiluted urine

AU - De Goede, M.

AU - Dijkstra, M.

AU - Obregón, R.

AU - Ramón-azcón, J.

AU - Martínez, E.

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AU - Mitjans, F.

AU - Garcia-blanco, S. M.

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AB - Concentrations down to 3 nM of the rhS100A4 protein, associated with human tumor development, have been detected in undiluted urine using an integrated sensor based on microring resonators in the emerging Al2O3 photonic platform. The fabricated microrings were designed for operation in the C-band (λ = 1565 nm) and exhibited a high-quality factor in air of 3.2 × 105. The bulk refractive index sensitivity of the devices was ~100 nm/RIU (for TM polarization) with a limit of detection of ~10−6 RIU. A surface functionalization protocol was developed to allow for the selective binding of the monoclonal antibodies designed to capture the target biomarker to the surface of the Al2O3 microrings. The detection of rhS100A4 proteins at clinically relevant concentrations in urine is a big milestone towards the use of biosensors for the screening and early diagnosis of different cancers. Biosensors based on this microring technology can lead to portable, multiplexed and easy-to-use point of care devices.

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