Al2O3:Yb3+ integrated microdisk laser label-free biosensor

Michiel De Goede, Lantian Chang, Jinfeng Mu, Meindert Dijkstra, Raquel Obregón, Elena Martínez, Laura Padilla, Francesc Mitjans, Sonia M. Garcia-Blanco*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Whispering gallery mode resonator lasers hold the promise of an ultralow intrinsic limit of detection. However, the widespread use of these devices for biosensing applications has been hindered by the complexity and lack of robustness of the proposed configurations. In this work, we demonstrate biosensing with an integrated microdisk laser. Al2O3doped with Yb3+ was utilized because of its low optical losses as well as its emission in the range 1020–1050 nm, outside the absorption band of water. Single-mode laser emission was obtained at a wavelength of 1024 nm with a linewidth of 250 kHz while the microdisk cavity was submerged in water. A limit of detection of 300 pM (3.6 ng/ml) of the protein rhS100A4 in urine was experimentally demonstrated, showing the potential of the proposed devices for biosensing.
Original languageEnglish
Pages (from-to)5937-5940
Number of pages4
JournalOptics letters
Volume44
Issue number24
DOIs
Publication statusPublished - 15 Dec 2019

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bioinstrumentation
urine
whispering gallery modes
laser modes
water
lasers
resonators
proteins
absorption spectra
cavities
configurations
wavelengths

Cite this

De Goede, Michiel ; Chang, Lantian ; Mu, Jinfeng ; Dijkstra, Meindert ; Obregón, Raquel ; Martínez, Elena ; Padilla, Laura ; Mitjans, Francesc ; Garcia-Blanco, Sonia M. / Al2O3:Yb3+ integrated microdisk laser label-free biosensor. In: Optics letters. 2019 ; Vol. 44, No. 24. pp. 5937-5940.
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title = "Al2O3:Yb3+ integrated microdisk laser label-free biosensor",
abstract = "Whispering gallery mode resonator lasers hold the promise of an ultralow intrinsic limit of detection. However, the widespread use of these devices for biosensing applications has been hindered by the complexity and lack of robustness of the proposed configurations. In this work, we demonstrate biosensing with an integrated microdisk laser. Al2O3doped with Yb3+ was utilized because of its low optical losses as well as its emission in the range 1020–1050 nm, outside the absorption band of water. Single-mode laser emission was obtained at a wavelength of 1024 nm with a linewidth of 250 kHz while the microdisk cavity was submerged in water. A limit of detection of 300 pM (3.6 ng/ml) of the protein rhS100A4 in urine was experimentally demonstrated, showing the potential of the proposed devices for biosensing.",
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Al2O3:Yb3+ integrated microdisk laser label-free biosensor. / De Goede, Michiel; Chang, Lantian; Mu, Jinfeng; Dijkstra, Meindert; Obregón, Raquel; Martínez, Elena; Padilla, Laura; Mitjans, Francesc; Garcia-Blanco, Sonia M.

In: Optics letters, Vol. 44, No. 24, 15.12.2019, p. 5937-5940.

Research output: Contribution to journalArticleAcademicpeer-review

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AU - Chang, Lantian

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