Algorithm for automatic detection of self-similarity and prediction of residual central respiratory events during continuous positive airway pressure

Eline Oppersma*, Wolfgang Ganglberger, Haoqi Sun, Robert J. Thomas, M. Brandon Westover

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)
45 Downloads (Pure)

Abstract

STUDY OBJECTIVES: Sleep-disordered breathing is a significant risk factor for cardiometabolic and neurodegenerative diseases. High loop gain (HLG) is a driving mechanism of central sleep apnea or periodic breathing. This study presents a computational approach that identifies "expressed/manifest" HLG via a cyclical self-similarity feature in effort-based respiration signals.

METHODS: Working under the assumption that HLG increases the risk of residual central respiratory events during continuous positive airway pressure (CPAP), the full night similarity, computed during diagnostic non-CPAP polysomnography (PSG), was used to predict residual central events during CPAP (REC), which we defined as central apnea index (CAI) higher than 10. Central apnea labels are obtained both from manual scoring by sleep technologists and from an automated algorithm developed for this study. The Massachusetts General Hospital sleep database was used, including 2466 PSG pairs of diagnostic and CPAP titration PSG recordings.

RESULTS: Diagnostic CAI based on technologist labels predicted REC with an area under the curve (AUC) of 0.82 ± 0.03. Based on automatically generated labels, the combination of full night similarity and automatically generated CAI resulted in an AUC of 0.85 ± 0.02. A subanalysis was performed on a population with technologist-labeled diagnostic CAI higher than 5. Full night similarity predicted REC with an AUC of 0.57 ± 0.07 for manual and 0.65 ± 0.06 for automated labels.

CONCLUSIONS: The proposed self-similarity feature, as a surrogate estimate of expressed respiratory HLG and computed from easily accessible effort signals, can detect periodic breathing regardless of admixed obstructive features such as flow limitation and can aid the prediction of REC.

Original languageEnglish
Article numberzsaa215
JournalSleep
Volume44
Issue number4
Early online date15 Oct 2020
DOIs
Publication statusPublished - 1 Apr 2021

Keywords

  • UT-Hybrid-D
  • CPAP
  • Similarity
  • Automatic detection

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