Abstract
Multivalent membrane binding sites on the α-synuclein oligomer result in clustering of vesicles and hemifusion of negatively charged model membranes. These multivalent, biological nanoparticles are reminiscent of inorganic nanoparticles in their interactions with membranes. Alpha-synuclein oligomers induce lipid exchange efficiently, with fewer than 10 oligomers/vesicle required to complete hemifusion. No full fusion or vesicle content mixing is observed
Original language | Undefined |
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Pages (from-to) | 2257-2262 |
Journal | Small |
Volume | 11 |
Issue number | 19 |
DOIs | |
Publication status | Published - 15 Jan 2015 |
Keywords
- IR-95651
- METIS-309191