Alpha-Synuclein Amyloid Oligomers Act as Multivalent Nanoparticles to Cause Hemifusion in Negatively Charged Vesicles

A. Stefanovic, Mireille Maria Anna Elisabeth Claessens, Christian Blum, Vinod Subramaniam

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Abstract

Multivalent membrane binding sites on the α-synuclein oligomer result in clustering of vesicles and hemifusion of negatively charged model membranes. These multivalent, biological nanoparticles are reminiscent of inorganic nanoparticles in their interactions with membranes. Alpha-synuclein oligomers induce lipid exchange efficiently, with fewer than 10 oligomers/vesicle required to complete hemifusion. No full fusion or vesicle content mixing is observed
Original languageUndefined
Pages (from-to)2257-2262
JournalSmall
Volume11
Issue number19
DOIs
Publication statusPublished - 15 Jan 2015

Keywords

  • IR-95651
  • METIS-309191

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