ALTMET polymerization of amino acid-based monomers targeting controlled drug release

Luana Becker Peres, Laura C. Preiss, Manfred Wagner, Frederik R. Wurm, Pedro H.H. De Araújo, Katharina Landfester, Rafael Muñoz-Espí*, Claudia Sayer

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Abstract

Giving the imminent necessity of a new generation of biodegradable and biocompatible polymers prepared from feedstock, the synthesis of a potentially biodegradable amino acid-based copolymer by the alternating diene metathesis (ALTMET) strategy is herein presented. The reaction was tailored to minimize isomerization and deactivation of ruthenium catalysts by intramolecular coordination with the amide carbonyl group of the amino-acid-based monomer. Alternated l-lysine-phosphoester copolymers with molar masses higher than 18000 g/mol were obtained using Hoveyda-Grubbs second-generation and Umicore M2 catalysts. The copolymer was further used to prepare nanoparticles loaded with rifampicin (up to 50 wt %) by the miniemulsion/solvent evaporation technique. The l-lysine-based copolymer is shown to be a promising material for biomedical applications, such as controlled drug delivery system.

Original languageEnglish
Pages (from-to)6723-6730
Number of pages8
JournalMacromolecules
Volume49
Issue number18
DOIs
Publication statusPublished - 27 Sep 2016
Externally publishedYes

Fingerprint Dive into the research topics of 'ALTMET polymerization of amino acid-based monomers targeting controlled drug release'. Together they form a unique fingerprint.

Cite this