Amoebid abscess of the liver with hepatobronchial fistula

C. Von Birgelen, J. Von Schonfeld, G. Gorge, W. Fabry, P. Layer

    Research output: Contribution to journalArticleAcademicpeer-review

    2 Citations (Scopus)

    Abstract

    Four weeks after a holiday in Kenya a 57-year-old woman developed a fever up to 40°C, right upper abdominal pain, icteric sclerae, nausea and vomiting. Laboratory tests revealed leukocytosis (24 400/μl), markedly accelerated erythrocyte sedimentation rate (123 mm/h) and moderately increased activity of liver enzymes in serum. The liver was unremarkable on ultrasound. Four days after hospitalization the patient complained of dyspnoea and pleuritic pain. Ultrasound examination and computed tomography showed an abscess in the right lobe of the liver. Amoebic abscess of the liver being the most likely diagnosis, although the relevant serological tests were unmarkable and a titre increase occurred only later, treatment was started with metronidazole (four times 500 mg daily intravenously) and paromomycin (three times 10 mg/kg daily). He condition significantly improved within a day. Two weeks later, however, she developed chest pain, dyspnoea and cough productive of large amounts of white-yellow sputum, even though antibiotic treatment was continuing. A transdiaphragmatic rupture of the abscess with formation of a hepatobronchial fistula proved to be the cause of these symptoms. The patient was treated surgically by drainage and suturing-over the extensive diaphragmatic defect and after 2 weeks she was discharged symptom-free on a maintenance dose of diloxanide furoate (three times 500 mg/d orally).

    Translated title of the contributionAmoebid abscess of the liver with hepatobronchial fistula
    Original languageGerman
    Pages (from-to)1034-1038
    Number of pages5
    JournalDeutsche Medizinische Wochenschrift
    Volume119
    Issue number30
    Publication statusPublished - 1 Jan 1994

    Fingerprint

    Liver Abscess
    Fistula
    Dyspnea
    Abscess
    Liver
    Paromomycin
    Amoebic Liver Abscess
    Holidays
    Sclera
    Kenya
    Blood Sedimentation
    Leukocytosis
    Metronidazole
    Serologic Tests
    Sputum
    Chest Pain
    Cough
    Nausea
    Abdominal Pain
    Vomiting

    Cite this

    Von Birgelen, C., Von Schonfeld, J., Gorge, G., Fabry, W., & Layer, P. (1994). Amobenabszess der Leber mit hepatobronchialer Fistel. Deutsche Medizinische Wochenschrift, 119(30), 1034-1038.
    Von Birgelen, C. ; Von Schonfeld, J. ; Gorge, G. ; Fabry, W. ; Layer, P. / Amobenabszess der Leber mit hepatobronchialer Fistel. In: Deutsche Medizinische Wochenschrift. 1994 ; Vol. 119, No. 30. pp. 1034-1038.
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    title = "Amobenabszess der Leber mit hepatobronchialer Fistel",
    abstract = "Four weeks after a holiday in Kenya a 57-year-old woman developed a fever up to 40°C, right upper abdominal pain, icteric sclerae, nausea and vomiting. Laboratory tests revealed leukocytosis (24 400/μl), markedly accelerated erythrocyte sedimentation rate (123 mm/h) and moderately increased activity of liver enzymes in serum. The liver was unremarkable on ultrasound. Four days after hospitalization the patient complained of dyspnoea and pleuritic pain. Ultrasound examination and computed tomography showed an abscess in the right lobe of the liver. Amoebic abscess of the liver being the most likely diagnosis, although the relevant serological tests were unmarkable and a titre increase occurred only later, treatment was started with metronidazole (four times 500 mg daily intravenously) and paromomycin (three times 10 mg/kg daily). He condition significantly improved within a day. Two weeks later, however, she developed chest pain, dyspnoea and cough productive of large amounts of white-yellow sputum, even though antibiotic treatment was continuing. A transdiaphragmatic rupture of the abscess with formation of a hepatobronchial fistula proved to be the cause of these symptoms. The patient was treated surgically by drainage and suturing-over the extensive diaphragmatic defect and after 2 weeks she was discharged symptom-free on a maintenance dose of diloxanide furoate (three times 500 mg/d orally).",
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    Von Birgelen, C, Von Schonfeld, J, Gorge, G, Fabry, W & Layer, P 1994, 'Amobenabszess der Leber mit hepatobronchialer Fistel' Deutsche Medizinische Wochenschrift, vol. 119, no. 30, pp. 1034-1038.

    Amobenabszess der Leber mit hepatobronchialer Fistel. / Von Birgelen, C.; Von Schonfeld, J.; Gorge, G.; Fabry, W.; Layer, P.

    In: Deutsche Medizinische Wochenschrift, Vol. 119, No. 30, 01.01.1994, p. 1034-1038.

    Research output: Contribution to journalArticleAcademicpeer-review

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    N2 - Four weeks after a holiday in Kenya a 57-year-old woman developed a fever up to 40°C, right upper abdominal pain, icteric sclerae, nausea and vomiting. Laboratory tests revealed leukocytosis (24 400/μl), markedly accelerated erythrocyte sedimentation rate (123 mm/h) and moderately increased activity of liver enzymes in serum. The liver was unremarkable on ultrasound. Four days after hospitalization the patient complained of dyspnoea and pleuritic pain. Ultrasound examination and computed tomography showed an abscess in the right lobe of the liver. Amoebic abscess of the liver being the most likely diagnosis, although the relevant serological tests were unmarkable and a titre increase occurred only later, treatment was started with metronidazole (four times 500 mg daily intravenously) and paromomycin (three times 10 mg/kg daily). He condition significantly improved within a day. Two weeks later, however, she developed chest pain, dyspnoea and cough productive of large amounts of white-yellow sputum, even though antibiotic treatment was continuing. A transdiaphragmatic rupture of the abscess with formation of a hepatobronchial fistula proved to be the cause of these symptoms. The patient was treated surgically by drainage and suturing-over the extensive diaphragmatic defect and after 2 weeks she was discharged symptom-free on a maintenance dose of diloxanide furoate (three times 500 mg/d orally).

    AB - Four weeks after a holiday in Kenya a 57-year-old woman developed a fever up to 40°C, right upper abdominal pain, icteric sclerae, nausea and vomiting. Laboratory tests revealed leukocytosis (24 400/μl), markedly accelerated erythrocyte sedimentation rate (123 mm/h) and moderately increased activity of liver enzymes in serum. The liver was unremarkable on ultrasound. Four days after hospitalization the patient complained of dyspnoea and pleuritic pain. Ultrasound examination and computed tomography showed an abscess in the right lobe of the liver. Amoebic abscess of the liver being the most likely diagnosis, although the relevant serological tests were unmarkable and a titre increase occurred only later, treatment was started with metronidazole (four times 500 mg daily intravenously) and paromomycin (three times 10 mg/kg daily). He condition significantly improved within a day. Two weeks later, however, she developed chest pain, dyspnoea and cough productive of large amounts of white-yellow sputum, even though antibiotic treatment was continuing. A transdiaphragmatic rupture of the abscess with formation of a hepatobronchial fistula proved to be the cause of these symptoms. The patient was treated surgically by drainage and suturing-over the extensive diaphragmatic defect and after 2 weeks she was discharged symptom-free on a maintenance dose of diloxanide furoate (three times 500 mg/d orally).

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    Von Birgelen C, Von Schonfeld J, Gorge G, Fabry W, Layer P. Amobenabszess der Leber mit hepatobronchialer Fistel. Deutsche Medizinische Wochenschrift. 1994 Jan 1;119(30):1034-1038.