An Atomic Force Microscopical Study of the Synaptonemal Complex

Constant A.J. Putman; Axel J.J. Dietrich; Bart G. de Grooth; Jan van Marle; Christa Heyting; Niek F. van Hulst; Jan Greve

doi:10.1016/0968-4328(93)90053-4

An Atomic Force Microscopical Study of the Synaptonemal Complex

Constant A.J. Putman, Axel J.J. Dietrich, Bart G. de Grooth, Jan van Marle, Christa Heyting, Niek F. van Hulst, Jan Greve

Optical Sciences

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Abstract

The chromosomal structure which is specific for meiosis, the synaptonemal complex (SC), plays a major role in chromosome pairing and the recombination of genetic material. The SC was studied using atomic force microscopy (AFM). The results of this study confirm the results of light and electron microscopic studies of the SC. The SC primarily shows a tripartite structure, composed of two lateral elements and a central element connected to each other by transversal elements. The lateral element of the SC shows a lateral subdivision in secondary lateral strands. In addition, a new repetitive transversal subdivision of the lateral elements was observed. Furthermore, the SC substructure which is probably responsible for recombination, the recombination nodule, could be observed ouside the confines of the SC.

Original language	English
Pages (from-to)	273-277
Number of pages	5
Journal	Micron
Volume	24
Issue number	3
DOIs	https://doi.org/10.1016/0968-4328(93)90053-4
Publication status	Published - 1993

Keywords

Atomic force microscopy (AFM)
Synaptonemal complex (SC)
Lateral element
Transversal element
Central element
Recombination nodule

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10.1016/0968-4328(93)90053-4

Putman1993atomicFinal published version, 335 KB

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title = "An Atomic Force Microscopical Study of the Synaptonemal Complex",

abstract = "The chromosomal structure which is specific for meiosis, the synaptonemal complex (SC), plays a major role in chromosome pairing and the recombination of genetic material. The SC was studied using atomic force microscopy (AFM). The results of this study confirm the results of light and electron microscopic studies of the SC. The SC primarily shows a tripartite structure, composed of two lateral elements and a central element connected to each other by transversal elements. The lateral element of the SC shows a lateral subdivision in secondary lateral strands. In addition, a new repetitive transversal subdivision of the lateral elements was observed. Furthermore, the SC substructure which is probably responsible for recombination, the recombination nodule, could be observed ouside the confines of the SC.",

keywords = "Atomic force microscopy (AFM), Synaptonemal complex (SC), Lateral element, Transversal element, Central element, Recombination nodule",

author = "Putman, {Constant A.J.} and Dietrich, {Axel J.J.} and {de Grooth}, {Bart G.} and {van Marle}, Jan and Christa Heyting and {van Hulst}, {Niek F.} and Jan Greve",

year = "1993",

doi = "10.1016/0968-4328(93)90053-4",

language = "English",

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AU - Putman, Constant A.J.

AU - Dietrich, Axel J.J.

AU - de Grooth, Bart G.

AU - van Marle, Jan

AU - Heyting, Christa

AU - van Hulst, Niek F.

AU - Greve, Jan

PY - 1993

Y1 - 1993

N2 - The chromosomal structure which is specific for meiosis, the synaptonemal complex (SC), plays a major role in chromosome pairing and the recombination of genetic material. The SC was studied using atomic force microscopy (AFM). The results of this study confirm the results of light and electron microscopic studies of the SC. The SC primarily shows a tripartite structure, composed of two lateral elements and a central element connected to each other by transversal elements. The lateral element of the SC shows a lateral subdivision in secondary lateral strands. In addition, a new repetitive transversal subdivision of the lateral elements was observed. Furthermore, the SC substructure which is probably responsible for recombination, the recombination nodule, could be observed ouside the confines of the SC.

AB - The chromosomal structure which is specific for meiosis, the synaptonemal complex (SC), plays a major role in chromosome pairing and the recombination of genetic material. The SC was studied using atomic force microscopy (AFM). The results of this study confirm the results of light and electron microscopic studies of the SC. The SC primarily shows a tripartite structure, composed of two lateral elements and a central element connected to each other by transversal elements. The lateral element of the SC shows a lateral subdivision in secondary lateral strands. In addition, a new repetitive transversal subdivision of the lateral elements was observed. Furthermore, the SC substructure which is probably responsible for recombination, the recombination nodule, could be observed ouside the confines of the SC.

KW - Atomic force microscopy (AFM)

KW - Synaptonemal complex (SC)

KW - Lateral element

KW - Transversal element

KW - Central element

KW - Recombination nodule

U2 - 10.1016/0968-4328(93)90053-4

DO - 10.1016/0968-4328(93)90053-4

M3 - Article

SN - 0047-7206

VL - 24

SP - 273

EP - 277

JO - Micron

JF - Micron

IS - 3

ER -

An Atomic Force Microscopical Study of the Synaptonemal Complex

Abstract

Keywords

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