An Automated Method for Artifical Intelligence Assisted Diagnosis of Active Aortitis Using Radiomic Analysis of FDG PET-CT Images

Lisa M. Duff*, Andrew F. Scarsbrook, Nishant Ravikumar, Russell Frood, Gijs D. van Praagh, Sarah L. Mackie, Marc A. Bailey, Jason M. Tarkin, Justin C. Mason, Kornelis S.M. van der Geest, Riemer H.J.A. Slart, Ann W. Morgan, Charalampos Tsoumpas

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)
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Abstract

The aim of this study was to develop and validate an automated pipeline that could assist the diagnosis of active aortitis using radiomic imaging biomarkers derived from [18F]-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography (FDG PET-CT) images. The aorta was automatically segmented by convolutional neural network (CNN) on FDG PET-CT of aortitis and control patients. The FDG PET-CT dataset was split into training (43 aortitis:21 control), test (12 aortitis:5 control) and validation (24 aortitis:14 control) cohorts. Radiomic features (RF), including SUV metrics, were extracted from the segmented data and harmonized. Three radiomic fingerprints were constructed: A—RFs with high diagnostic utility removing highly correlated RFs; B used principal component analysis (PCA); C—Random Forest intrinsic feature selection. The diagnostic utility was evaluated with accuracy and area under the receiver operating characteristic curve (AUC). Several RFs and Fingerprints had high AUC values (AUC > 0.8), confirmed by balanced accuracy, across training, test and external validation datasets. Good diagnostic performance achieved across several multi-centre datasets suggests that a radiomic pipeline can be generalizable. These findings could be used to build an automated clinical decision tool to facilitate objective and standardized assessment regardless of observer experience.

Original languageEnglish
Article number343
Number of pages33
JournalBiomolecules
Volume13
Issue number2
Early online date9 Feb 2023
DOIs
Publication statusPublished - Feb 2023

Keywords

  • aortitis
  • convolutional neural network
  • machine learning
  • positron emission tomography/computed tomography
  • radiomics

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