An Extended Twin-Pedigree Study of Neuroticism in the Netherlands Twin Register

Dorret I. Boomsma (Corresponding Author), Quinta Helmer, Harold A. Nieuwboer, Jouke-Jan Hottenga, Marleen H.M. Moor, Stéphanie M. van Den Berg, Gareth E. Davies, Jacqueline M. Vink, Maarten J. Schouten, Conor V. Dolan, Gonneke Willemsen, Meike Bartels, Toos C.E.M. van Beijsterveldt, Lannie Ligthart, Eco J.C. de Geus

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Abstract

For the participants in the Netherlands Twin Register (NTR) we constructed the extended pedigrees which specify all relations among nuclear and larger twin families in the register. A total of 253,015 subjects from 58,645 families were linked to each other, to the degree that we had information on the relations among participants. We describe the algorithm that was applied to construct the pedigrees. For > 30,000 adolescent and adult NTR participants data were available on harmonized neuroticism scores. We analyzed these data in the Mendel software package (Lange et al., Bioinformatics 29(12):1568–1570, 2013) to estimate the contributions of additive and non-additive genetic factors. In contrast to much of the earlier work based on twin data rather than on extended pedigrees, we could also estimate the contribution of shared household effects in the presence of non-additive genetic factors. The estimated broad-sense heritability of neuroticism was 47%, with almost equal contributions of additive and non-additive (dominance) genetic factors. A shared household effect explained 13% and unique environmental factors explained the remaining 40% of the variance in neuroticism.

Original languageEnglish
Pages (from-to)1-11
Number of pages11
JournalBehavior genetics
Volume48
Issue number1
DOIs
Publication statusPublished - 1 Jan 2018

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Twin Studies
Pedigree
pedigree
Netherlands
households
bioinformatics
heritability
environmental factor
Computational Biology
dominance (genetics)
software
Software
environmental factors
Neuroticism
family
household
effect

Keywords

  • Extended twin-family design
  • Genetic non-additivity
  • Heritability
  • Netherlands Twin Register
  • Neuroticism
  • Pedigree analysis
  • Shared household effect

Cite this

Boomsma, D. I., Helmer, Q., Nieuwboer, H. A., Hottenga, J-J., Moor, M. H. M., van Den Berg, S. M., ... de Geus, E. J. C. (2018). An Extended Twin-Pedigree Study of Neuroticism in the Netherlands Twin Register. Behavior genetics, 48(1), 1-11. https://doi.org/10.1007/s10519-017-9872-0
Boomsma, Dorret I. ; Helmer, Quinta ; Nieuwboer, Harold A. ; Hottenga, Jouke-Jan ; Moor, Marleen H.M. ; van Den Berg, Stéphanie M. ; Davies, Gareth E. ; Vink, Jacqueline M. ; Schouten, Maarten J. ; Dolan, Conor V. ; Willemsen, Gonneke ; Bartels, Meike ; van Beijsterveldt, Toos C.E.M. ; Ligthart, Lannie ; de Geus, Eco J.C. / An Extended Twin-Pedigree Study of Neuroticism in the Netherlands Twin Register. In: Behavior genetics. 2018 ; Vol. 48, No. 1. pp. 1-11.
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Boomsma, DI, Helmer, Q, Nieuwboer, HA, Hottenga, J-J, Moor, MHM, van Den Berg, SM, Davies, GE, Vink, JM, Schouten, MJ, Dolan, CV, Willemsen, G, Bartels, M, van Beijsterveldt, TCEM, Ligthart, L & de Geus, EJC 2018, 'An Extended Twin-Pedigree Study of Neuroticism in the Netherlands Twin Register' Behavior genetics, vol. 48, no. 1, pp. 1-11. https://doi.org/10.1007/s10519-017-9872-0

An Extended Twin-Pedigree Study of Neuroticism in the Netherlands Twin Register. / Boomsma, Dorret I. (Corresponding Author); Helmer, Quinta; Nieuwboer, Harold A.; Hottenga, Jouke-Jan; Moor, Marleen H.M.; van Den Berg, Stéphanie M.; Davies, Gareth E.; Vink, Jacqueline M.; Schouten, Maarten J.; Dolan, Conor V.; Willemsen, Gonneke; Bartels, Meike; van Beijsterveldt, Toos C.E.M.; Ligthart, Lannie; de Geus, Eco J.C.

In: Behavior genetics, Vol. 48, No. 1, 01.01.2018, p. 1-11.

Research output: Contribution to journalArticleAcademicpeer-review

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AU - Moor, Marleen H.M.

AU - van Den Berg, Stéphanie M.

AU - Davies, Gareth E.

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AU - Schouten, Maarten J.

AU - Dolan, Conor V.

AU - Willemsen, Gonneke

AU - Bartels, Meike

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AU - de Geus, Eco J.C.

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