An Investigation of the Sensing Capabilities of Magnetotactic Bacteria

Nermeen S. El-Din, Anke Klingner, Mohamed Ewis, Noura Yousry, Ola Ahmed, Iman Gomaa, Tijmen Hageman, Marc Pichel, Mohamed E. Mitwally, Leon Abelmann, Islam S.M. Khalil

    Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

    Abstract

    We investigate the sensing capabilities of magnetotactic bacteria (Magnetospirillum gryphiswaldense strain MSR1) to MCF-7 breast cancer cells. Cancer cells are allowed to grow inside a capillary tube with depth of 200 μ m and motion of magnetotactic bacteria is investigated under the influence of oxygen gradient and geomagnetic field. The influence of cancer cells is modeled to predict the oxygen gradient within the capillary tube in three-dimensional space. Our experimental motion analysis and count of motile magnetotactic bacteria indicate that they migrate towards less-oxygenated regions within the vicinity of cancer cells. Bands of magnetotactic bacteria with average concentration of 18.8±2.0% are observed in close proximity to MCF-7 cells (h = 20~ μ m), whereas the concentration at proximity of 190~ μ m is 5.0 ± 6.8%.

    Original languageEnglish
    Title of host publication40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018
    PublisherIEEE
    Pages1739-1742
    Number of pages4
    ISBN (Electronic)9781538636466
    DOIs
    Publication statusPublished - 26 Oct 2018
    Event40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018 - Hawaii Convention Center, Honolulu, United States
    Duration: 17 Jul 201821 Jul 2018
    Conference number: 40
    https://embc.embs.org/2018/

    Conference

    Conference40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018
    Abbreviated titleEMBC 2018
    CountryUnited States
    CityHonolulu
    Period17/07/1821/07/18
    Internet address

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