An Investigation of the Sensing Capabilities of Magnetotactic Bacteria

Nermeen S. El-Din; Anke Klingner; Mohamed Ewis; Noura Yousry; Ola Ahmed; Iman Gomaa; Tijmen Hageman; Marc Pichel; Mohamed E. Mitwally; Leon Abelmann; Islam S.M. Khalil

doi:10.1109/EMBC.2018.8512676

An Investigation of the Sensing Capabilities of Magnetotactic Bacteria

Nermeen S. El-Din, Anke Klingner, Mohamed Ewis, Noura Yousry, Ola Ahmed, Iman Gomaa, Tijmen Hageman, Marc Pichel, Mohamed E. Mitwally, Leon Abelmann, Islam S.M. Khalil

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

19 Downloads (Pure)

Abstract

We investigate the sensing capabilities of magnetotactic bacteria (Magnetospirillum gryphiswaldense strain MSR1) to MCF-7 breast cancer cells. Cancer cells are allowed to grow inside a capillary tube with depth of 200 μ m and motion of magnetotactic bacteria is investigated under the influence of oxygen gradient and geomagnetic field. The influence of cancer cells is modeled to predict the oxygen gradient within the capillary tube in three-dimensional space. Our experimental motion analysis and count of motile magnetotactic bacteria indicate that they migrate towards less-oxygenated regions within the vicinity of cancer cells. Bands of magnetotactic bacteria with average concentration of 18.8±2.0% are observed in close proximity to MCF-7 cells (h = 20~ μ m), whereas the concentration at proximity of 190~ μ m is 5.0 ± 6.8%.

Original language	English
Title of host publication	40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018
Publisher	IEEE
Pages	1739-1742
Number of pages	4
ISBN (Electronic)	9781538636466
DOIs	https://doi.org/10.1109/EMBC.2018.8512676
Publication status	Published - 26 Oct 2018
Event	40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018 - Hawaii Convention Center, Honolulu, United States Duration: 17 Jul 2018 → 21 Jul 2018 Conference number: 40 https://embc.embs.org/2018/

Conference

Conference	40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018
Abbreviated title	EMBC 2018
Country/Territory	United States
City	Honolulu
Period	17/07/18 → 21/07/18
Internet address	https://embc.embs.org/2018/

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1109/EMBC.2018.8512676

Cite this

El-Din, N. S., Klingner, A., Ewis, M., Yousry, N., Ahmed, O., Gomaa, I., Hageman, T., Pichel, M., Mitwally, M. E., Abelmann, L., & Khalil, I. S. M. (2018). An Investigation of the Sensing Capabilities of Magnetotactic Bacteria. In 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018 (pp. 1739-1742). Article 8512676 IEEE. https://doi.org/10.1109/EMBC.2018.8512676

@inproceedings{dcb0c15d93824b5ab951af376d60b0ce,

title = "An Investigation of the Sensing Capabilities of Magnetotactic Bacteria",

abstract = "We investigate the sensing capabilities of magnetotactic bacteria (Magnetospirillum gryphiswaldense strain MSR1) to MCF-7 breast cancer cells. Cancer cells are allowed to grow inside a capillary tube with depth of 200 μ m and motion of magnetotactic bacteria is investigated under the influence of oxygen gradient and geomagnetic field. The influence of cancer cells is modeled to predict the oxygen gradient within the capillary tube in three-dimensional space. Our experimental motion analysis and count of motile magnetotactic bacteria indicate that they migrate towards less-oxygenated regions within the vicinity of cancer cells. Bands of magnetotactic bacteria with average concentration of 18.8±2.0% are observed in close proximity to MCF-7 cells (h = 20~ μ m), whereas the concentration at proximity of 190~ μ m is 5.0 ± 6.8%.",

author = "El-Din, {Nermeen S.} and Anke Klingner and Mohamed Ewis and Noura Yousry and Ola Ahmed and Iman Gomaa and Tijmen Hageman and Marc Pichel and Mitwally, {Mohamed E.} and Leon Abelmann and Khalil, {Islam S.M.}",

year = "2018",

month = oct,

day = "26",

doi = "10.1109/EMBC.2018.8512676",

language = "English",

pages = "1739--1742",

booktitle = "40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018",

publisher = "IEEE",

address = "United States",

note = "40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018, EMBC 2018 ; Conference date: 17-07-2018 Through 21-07-2018",

url = "https://embc.embs.org/2018/",

}

El-Din, NS, Klingner, A, Ewis, M, Yousry, N, Ahmed, O, Gomaa, I, Hageman, T, Pichel, M, Mitwally, ME, Abelmann, L & Khalil, ISM 2018, An Investigation of the Sensing Capabilities of Magnetotactic Bacteria. in 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018., 8512676, IEEE, pp. 1739-1742, 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018, Honolulu, Hawaii, United States, 17/07/18. https://doi.org/10.1109/EMBC.2018.8512676

An Investigation of the Sensing Capabilities of Magnetotactic Bacteria. / El-Din, Nermeen S.; Klingner, Anke; Ewis, Mohamed et al.
40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018. IEEE, 2018. p. 1739-1742 8512676.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

TY - GEN

T1 - An Investigation of the Sensing Capabilities of Magnetotactic Bacteria

AU - El-Din, Nermeen S.

AU - Klingner, Anke

AU - Ewis, Mohamed

AU - Yousry, Noura

AU - Ahmed, Ola

AU - Gomaa, Iman

AU - Hageman, Tijmen

AU - Pichel, Marc

AU - Mitwally, Mohamed E.

AU - Abelmann, Leon

AU - Khalil, Islam S.M.

N1 - Conference code: 40

PY - 2018/10/26

Y1 - 2018/10/26

N2 - We investigate the sensing capabilities of magnetotactic bacteria (Magnetospirillum gryphiswaldense strain MSR1) to MCF-7 breast cancer cells. Cancer cells are allowed to grow inside a capillary tube with depth of 200 μ m and motion of magnetotactic bacteria is investigated under the influence of oxygen gradient and geomagnetic field. The influence of cancer cells is modeled to predict the oxygen gradient within the capillary tube in three-dimensional space. Our experimental motion analysis and count of motile magnetotactic bacteria indicate that they migrate towards less-oxygenated regions within the vicinity of cancer cells. Bands of magnetotactic bacteria with average concentration of 18.8±2.0% are observed in close proximity to MCF-7 cells (h = 20~ μ m), whereas the concentration at proximity of 190~ μ m is 5.0 ± 6.8%.

AB - We investigate the sensing capabilities of magnetotactic bacteria (Magnetospirillum gryphiswaldense strain MSR1) to MCF-7 breast cancer cells. Cancer cells are allowed to grow inside a capillary tube with depth of 200 μ m and motion of magnetotactic bacteria is investigated under the influence of oxygen gradient and geomagnetic field. The influence of cancer cells is modeled to predict the oxygen gradient within the capillary tube in three-dimensional space. Our experimental motion analysis and count of motile magnetotactic bacteria indicate that they migrate towards less-oxygenated regions within the vicinity of cancer cells. Bands of magnetotactic bacteria with average concentration of 18.8±2.0% are observed in close proximity to MCF-7 cells (h = 20~ μ m), whereas the concentration at proximity of 190~ μ m is 5.0 ± 6.8%.

UR - http://www.scopus.com/inward/record.url?scp=85056624619&partnerID=8YFLogxK

U2 - 10.1109/EMBC.2018.8512676

DO - 10.1109/EMBC.2018.8512676

M3 - Conference contribution

C2 - 30440731

AN - SCOPUS:85056624619

SP - 1739

EP - 1742

BT - 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018

PB - IEEE

T2 - 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018

Y2 - 17 July 2018 through 21 July 2018

ER -

An Investigation of the Sensing Capabilities of Magnetotactic Bacteria

Abstract

Conference

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this