An Investigation of the Sensing Capabilities of Magnetotactic Bacteria

Nermeen S. El-Din, Anke Klingner, Mohamed Ewis, Noura Yousry, Ola Ahmed, Iman Gomaa, Tijmen Hageman, Marc Pichel, Mohamed E. Mitwally, Leon Abelmann, Islam S.M. Khalil

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Abstract

We investigate the sensing capabilities of magnetotactic bacteria (Magnetospirillum gryphiswaldense strain MSR1) to MCF-7 breast cancer cells. Cancer cells are allowed to grow inside a capillary tube with depth of 200 μ m and motion of magnetotactic bacteria is investigated under the influence of oxygen gradient and geomagnetic field. The influence of cancer cells is modeled to predict the oxygen gradient within the capillary tube in three-dimensional space. Our experimental motion analysis and count of motile magnetotactic bacteria indicate that they migrate towards less-oxygenated regions within the vicinity of cancer cells. Bands of magnetotactic bacteria with average concentration of 18.8±2.0% are observed in close proximity to MCF-7 cells (h = 20~ μ m), whereas the concentration at proximity of 190~ μ m is 5.0 ± 6.8%.

Original languageEnglish
Title of host publication40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018
PublisherIEEE
Pages1739-1742
Number of pages4
ISBN (Electronic)9781538636466
DOIs
Publication statusPublished - 26 Oct 2018
Event40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society 2018 - Hawaii Convention Center, Honolulu, United States
Duration: 17 Jul 201821 Jul 2018
Conference number: 40
https://embc.embs.org/2018/

Conference

Conference40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society 2018
Abbreviated titleEMBC 2018
CountryUnited States
CityHonolulu
Period17/07/1821/07/18
Internet address

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Bacteria
Cells
Capillary tubes
Magnetospirillum
Oxygen
Neoplasms
MCF-7 Cells
Breast Neoplasms

Cite this

El-Din, N. S., Klingner, A., Ewis, M., Yousry, N., Ahmed, O., Gomaa, I., ... Khalil, I. S. M. (2018). An Investigation of the Sensing Capabilities of Magnetotactic Bacteria. In 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018 (pp. 1739-1742). [8512676] IEEE. https://doi.org/10.1109/EMBC.2018.8512676
El-Din, Nermeen S. ; Klingner, Anke ; Ewis, Mohamed ; Yousry, Noura ; Ahmed, Ola ; Gomaa, Iman ; Hageman, Tijmen ; Pichel, Marc ; Mitwally, Mohamed E. ; Abelmann, Leon ; Khalil, Islam S.M. / An Investigation of the Sensing Capabilities of Magnetotactic Bacteria. 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018. IEEE, 2018. pp. 1739-1742
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abstract = "We investigate the sensing capabilities of magnetotactic bacteria (Magnetospirillum gryphiswaldense strain MSR1) to MCF-7 breast cancer cells. Cancer cells are allowed to grow inside a capillary tube with depth of 200 μ m and motion of magnetotactic bacteria is investigated under the influence of oxygen gradient and geomagnetic field. The influence of cancer cells is modeled to predict the oxygen gradient within the capillary tube in three-dimensional space. Our experimental motion analysis and count of motile magnetotactic bacteria indicate that they migrate towards less-oxygenated regions within the vicinity of cancer cells. Bands of magnetotactic bacteria with average concentration of 18.8±2.0{\%} are observed in close proximity to MCF-7 cells (h = 20~ μ m), whereas the concentration at proximity of 190~ μ m is 5.0 ± 6.8{\%}.",
author = "El-Din, {Nermeen S.} and Anke Klingner and Mohamed Ewis and Noura Yousry and Ola Ahmed and Iman Gomaa and Tijmen Hageman and Marc Pichel and Mitwally, {Mohamed E.} and Leon Abelmann and Khalil, {Islam S.M.}",
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El-Din, NS, Klingner, A, Ewis, M, Yousry, N, Ahmed, O, Gomaa, I, Hageman, T, Pichel, M, Mitwally, ME, Abelmann, L & Khalil, ISM 2018, An Investigation of the Sensing Capabilities of Magnetotactic Bacteria. in 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018., 8512676, IEEE, pp. 1739-1742, 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society 2018, Honolulu, United States, 17/07/18. https://doi.org/10.1109/EMBC.2018.8512676

An Investigation of the Sensing Capabilities of Magnetotactic Bacteria. / El-Din, Nermeen S.; Klingner, Anke; Ewis, Mohamed; Yousry, Noura; Ahmed, Ola; Gomaa, Iman; Hageman, Tijmen; Pichel, Marc; Mitwally, Mohamed E.; Abelmann, Leon; Khalil, Islam S.M.

40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018. IEEE, 2018. p. 1739-1742 8512676.

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

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AU - Ewis, Mohamed

AU - Yousry, Noura

AU - Ahmed, Ola

AU - Gomaa, Iman

AU - Hageman, Tijmen

AU - Pichel, Marc

AU - Mitwally, Mohamed E.

AU - Abelmann, Leon

AU - Khalil, Islam S.M.

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N2 - We investigate the sensing capabilities of magnetotactic bacteria (Magnetospirillum gryphiswaldense strain MSR1) to MCF-7 breast cancer cells. Cancer cells are allowed to grow inside a capillary tube with depth of 200 μ m and motion of magnetotactic bacteria is investigated under the influence of oxygen gradient and geomagnetic field. The influence of cancer cells is modeled to predict the oxygen gradient within the capillary tube in three-dimensional space. Our experimental motion analysis and count of motile magnetotactic bacteria indicate that they migrate towards less-oxygenated regions within the vicinity of cancer cells. Bands of magnetotactic bacteria with average concentration of 18.8±2.0% are observed in close proximity to MCF-7 cells (h = 20~ μ m), whereas the concentration at proximity of 190~ μ m is 5.0 ± 6.8%.

AB - We investigate the sensing capabilities of magnetotactic bacteria (Magnetospirillum gryphiswaldense strain MSR1) to MCF-7 breast cancer cells. Cancer cells are allowed to grow inside a capillary tube with depth of 200 μ m and motion of magnetotactic bacteria is investigated under the influence of oxygen gradient and geomagnetic field. The influence of cancer cells is modeled to predict the oxygen gradient within the capillary tube in three-dimensional space. Our experimental motion analysis and count of motile magnetotactic bacteria indicate that they migrate towards less-oxygenated regions within the vicinity of cancer cells. Bands of magnetotactic bacteria with average concentration of 18.8±2.0% are observed in close proximity to MCF-7 cells (h = 20~ μ m), whereas the concentration at proximity of 190~ μ m is 5.0 ± 6.8%.

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El-Din NS, Klingner A, Ewis M, Yousry N, Ahmed O, Gomaa I et al. An Investigation of the Sensing Capabilities of Magnetotactic Bacteria. In 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018. IEEE. 2018. p. 1739-1742. 8512676 https://doi.org/10.1109/EMBC.2018.8512676